| 1 |
Introduction: Dimensions of information available to define the unknown causes of common diseases |
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| 2 |
Public health records and estimation of age-specific risk |
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| 3 |
Effects of changes in diagnosis, prevention and therapy on historical mortality rates
Sources of differences in reported incidence and mortality |
PS 1 due |
| 4 |
Mathematical models derived from histopathological observations and age-specific mortality/incidence data
Examples: lung and colorectal cancers |
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| 5 |
Initiation |
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| 6 |
Promotion and Progression |
Term paper chapter 1 due |
| 7 |
Multiparametric Analysis of Colon Cancer |
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| 8 |
Multiparametric Analysis of Lung Cancer |
PS 3 due |
| 9 |
Role of Gender |
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| 10 |
Sub-populations at Risk |
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| 11 |
National Risk and Community Risk |
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| 12 |
Familial Risk Expectations |
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| 13 |
Familial Risk Observations |
Term paper chapter 2 due |
| 14 |
Population Genetics |
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| 15 |
Population Genetics (cont.) |
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| 16 |
The search for genes carrying mutations conferring risk for common diseases |
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| 17 |
The search for genes carrying mutations conferring risk for common diseases (cont.) |
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| 18 |
The search for genes carrying mutations conferring risk for common diseases (cont.) |
Term paper chapter 3 due |
| 19 |
The search for genes carrying mutations conferring risk for common diseases (cont.) |
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| 20 |
The search for genes in which mutations of initiation (and promotion, if any) occur in common human cancers |
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| 21 |
The origins of somatic and inherited mutations in humans |
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| 22 |
The origins of somatic and inherited mutations in humans (cont.) |
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| 23 |
Hypotheses that need testing |
Term paper chapter 4 due |
| 24 |
Evolution, embryogenesis and carcinogenesis (Guest lecturer: Dr. Elena V. Gostjeva)
Putting it together: Gostjeva-Thilly cascade model for risk and genesis of common clonal diseases |
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| 25-27 |
General discussion and student presentations |
Final term paper due |