| 1 |
Course Introduction
Model networks involved in signaling - Signals that start outside of the cell (role of the ECM) and trigger cascades inside the cell, ultimately affecting gene expression |
| 2 |
Information flow in the reverse direction - from DNA to RNA to protein (the central dogma)
Review of regulatory circuits and introduction to the concept of evolutionary genomics (PDF)
Key Issues: DNA replication and repair errors lead to mutations. Loss of mismatch repair leads to a hyper-Rec phenotype, which facilitates horizontal gene transfer (antibiotic resistance, etc.) |
| 3 |
Decoding Information I (Transcription Regulation) (PDF) |
| 4 |
Modeling Macromolecular Structure I
Individual Homework Assignments |
| 5 |
Decoding Information II (Translation) (PDF) |
| 6 |
Modeling Macromolecular Structure II
Students Present Homework |
| 7 |
Roundtable Discussion |
| 8 |
How to Write an NIH Grant Proposal |
| 9 |
Analysis of the Interferon Network (The JAK/STAT system) (PDF) |
| 10 |
Analysis of the Interferon Network (PDF) |
| 11 |
Analysis of the Interferon Network (cont.) |
| 12 |
Analysis of the Interferon Network (cont.) (PDF) |
| 13 |
Roundtable 1: Students Present Model Projects on Apoptosis |
| 14 |
Chemotaxis I - How Salvage Pathways Supplement Core Biochemical Pathways (PDF)
The Che System
Receptor Methylation as a Mechanism of Control of Chemotaxis |
| 15 |
Chemotaxis II - How CheY(P) Signals to the Flagellar Motor
Chemiosmotic Coupling
Chemotaxis III - Proton Pumps |
| 16 |
Introduction to the Extracellular Matrix |
| 17 |
Epithelial Cell Morphogenesis Signaling Hierarchy I |
| 18 |
Epithelial Cell Morphogenesis Signaling Hierarchy II |
| 19 |
Round Table Discussion |
| 20 |
Epithelial Cell Morphogenesis Signaling Hierarchy III |
| 21 |
Roundtable 3 |
| 22 |
Changes in Lung Epithelium During Pathogenesis I |
| 23 |
Changes in Lung Epithelium During Pathogenesis II |
| 24 |
Network Example: Functional Glycomics |