| I. Tissue Environment of the Implanted Biomaterial: Unit Cell Processes |
| L1 |
Survey of Clinical Cases of Biomaterials-Tissue Interactions |
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| L2 |
Tissue Structures, Unit Cell Processes, and Integrins |
Homework 1 due |
| L3 |
Unit Cell Processes Comprising the Healing Response |
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| L4 |
Irreversible Healing Behavior of the Extracellular Matrix (ECM) of Organs |
Homework 2 due |
| L5 |
Biochemistry of the ECM |
Homework 3 due |
| L6 |
Scaffolds Based on ECM Analogs Used in Organ Synthesis |
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| L7 |
Organ Replacement by Induced Regeneration and Tissue Engineering |
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| L8 |
Principles and Practice of Tissue Engineering |
Homework 4 due |
| E1 |
Quiz 1 |
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| II. Physicochemical Interactions at the Surface of Biomaterials and Signaling within Tissue |
| L9 |
Characteristics of the Surfaces of Biomaterials |
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| L10 |
Methodology for the Analysis of Surfaces |
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| L11 |
Physicochemical Principles of Protein Adsorption on Solid Surfaces |
Homework 5 due |
| L12 |
Protein/Cell/Tissue-Biomaterials Interactions |
Homework 6 due |
| L13 |
Linear vs. Cooperative Cell-Matrix Interactions |
Homework 7 due |
| L14 |
Cell-Matrix Interactions During Spontaneous Healing |
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| L15 |
Contraction-Blocking Theory of Regeneration in Adults |
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| E2 |
Quiz 2 |
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| III. In Vivo and Clinical Case Studies |
| L16 |
Joints and Dental Tissues: Prosthetic Replacement |
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| L17 |
Joints and Dental Tissues: Regeneration 1 |
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| L18 |
Joints and Dental Tissues: Regeneration 2 |
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| L19 |
Epithelialization (Epidermal Regeneration) and Endothelialization of Vascular Prostheses |
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| L20 |
Rules for Synthesis of Tissues and Organs |
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| L21 |
In Vivo Synthesis of Skin |
Homework 8 due |
| L22 |
In Vivo Synthesis of Peripheral Nerves |
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| L23 |
In Vivo Synthesis of the Conjunctiva and of Kidney Tissue |
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| E3 |
Quiz 3 |
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