| I. Tissue Environment of the Implanted Biomaterial: Unit Cell Processes |
| L1 |
Survey of Clinical Cases of Biomaterials-Tissue Interactions |
Yannas/Spector |
Introduction by Spector (PDF)
Introduction by Yannas (PDF) |
| L2 |
Tissue Structures, Unit Cell Processes, and Integrins |
Spector |
Tools for Understanding the Molecular, Cellular, and Physiological, Bases of the Tissue Response to Implants (PDF)
Introduction: Tissue Types (PDF - 1.7 MB)
Unit Cell Processes (PDF)
Integrins (PDF) |
| L3 |
Unit Cell Processes Comprising the Healing Response |
Spector |
UCPs in the Healing Environment (PDF)
Formation of Soft Tissue and Bone Around Implants: The Chronic Response to Implants (PDF) |
| L4 |
Irreversible Healing Behavior of the Extracellular Matrix (ECM) of Organs |
Yannas |
Irreversible Healing of Extracellular Matrix (PDF) |
| L5 |
Biochemistry of the ECM |
Yannas |
Naturally Occuring ECMs: Collagen (PDF - 1.1 MB)
Naturally Occuring ECMs: Elastin, PG and GAG, CAM (PDF) |
| L6 |
Scaffolds Based on ECM Analogs Used in Organ Synthesis |
Yannas |
Synthesis of Biologically Active Scaffolds (Regeneration Templates) (PDF) |
| L7 |
Organ Replacement by Induced Regeneration and Tissue Engineering |
Yannas/Spector |
Tissue Engineering: Overview (PDF) |
| L8 |
Principles and Practice of Tissue Engineering |
Spector |
Tissue Engineering: Stem Cells (PDF - 1.5 MB) |
| E1 |
Quiz 1 |
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| II. Physicochemical Interactions at the Surface of Biomaterials and Signaling within Tissue |
| L9 |
Characteristics of the Surfaces of Biomaterials |
Spector |
Materials: Bonding and Properties (PDF)
Cell-Matrix Interactions (PDF)
Response to Particles (PDF) |
| L10 |
Methodology for the Analysis of Surfaces |
Spector |
|
| L11 |
Physicochemical Principles of Protein Adsorption on Solid Surfaces |
Spector |
|
| L12 |
Protein/Cell/Tissue-Biomaterials Interactions |
Spector |
|
| L13 |
Linear vs. Cooperative Cell-Matrix Interactions |
Yannas |
Cell-Matrix Interactions [That Determine Biomaterials Function In Vitro and In Vivo] (PDF) |
| L14 |
Cell-Matrix Interactions During Spontaneous Healing |
Yannas |
Cell-Matrix Interactions - Part B (PDF) |
| L15 |
Contraction-Blocking Theory of Regeneration in Adults |
Yannas |
Cell-Matrix Interactions - Part C (PDF)
A Theory of Induced Regeneration in Adults (PDF) |
| E2 |
Quiz 2 |
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| III. In Vivo and Clinical Case Studies |
| L16 |
Joints and Dental Tissues: Prosthetic Replacement |
Spector |
Materials for Joint Replacement (PDF) |
| L17 |
Joints and Dental Tissues: Regeneration 1 |
Spector |
Biomaterials for Joint Regeneration 1 (PDF) |
| L18 |
Joints and Dental Tissues: Regeneration 2 |
Spector |
Dental Tissue Regeneration (PDF)
Biomaterials for Joint Regeneration 2 (PDF - 1.2 MB) |
| L19 |
Epithelialization (Epidermal Regeneration) and Endothelialization of Vascular Prostheses |
Spector |
|
| L20 |
Rules for Synthesis of Tissues and Organs |
Yannas |
Simplest Synthetic Pathways (PDF) |
| L21 |
In Vivo Synthesis of Skin |
Yannas |
Methodology of Organ Synthesis (PDF) |
| L22 |
In Vivo Synthesis of Peripheral Nerves |
Yannas |
Conjunctiva Synthesis In Vivo (Regeneration) (PDF) |
| L23 |
In Vivo Synthesis of the Conjunctiva and of Kidney Tissue |
Yannas |
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| E3 |
Quiz 3 |
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