| 1 |
Important Role of Water Molecule, Hydration of Amino Acids, Protein and Other Biological Materials |
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| 2 |
Amino Acids: Their Chemical and Physical Properties
Influence of Ionic Strength, pH, etc. |
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| 3 |
Primary and Secondary Structures of Proteins
Dihedral Angles, Peptide Bonds, Planar Structure, Relationship and Propensity of Amino Acid Sequence, Secondary Structure
Ramachandran Plot |
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| 4 |
Alpha-helices, 310 Helix, pi Helix, Beta-helices, etc.
Variation of Helices and Their Helical Bundles, Two Strand Coiled-coils, Three or Four Strand Coiled-coils, Supercoils
Various Helical Rich Protein Structure Models
Alpha-helices in Biological Materials |
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| 5 |
Helical Coiled-coils
Two-, Three-, Four- Stranded Helical Bundles
Applying Coiled-coils to Nanomaterials, Molecular Springs, Switches, etc. |
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| 6 |
Beta Sheets: Antiparallel, Parallel, and Twist
Beta Sheet Rich Proteins
Beta Sheets in Biological Materials |
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| 7 |
Practical Aspects of Single Crystal X-ray Crystallography, Part 1
X-ray Single Crystal Diffraction, Fiber Diffraction
Preparation of the Samples for Diffraction Analyses |
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| 8 |
NMR (Guest Lecturer: Peter Carr, MIT Media Lab) |
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| 9 |
Practical Aspects of Single Crystal X-ray Crystallography, Part 2 |
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| 10 |
Analytical Approaches and Instrumentation (Guest Lecturer: Sotirus Koutsopoulos, Ph.D) |
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| 11 |
Silk |
Take-home midterm exam out |
| 12 |
Biomineralization: Sea Creatures |
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| 13 |
Biomineralization: Bones and Teeth |
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| 14 |
Bioadhesives |
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| 15 |
Lipids as Building Materials |
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| 16 |
Polysaccharides and Oligosaccharides |
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| 17 |
Francis Crick Film |
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| 18 |
Molecular Structure and Self-assembly of DNA and RNA |
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| 19 |
Macromolecular Interactions and Protein and Adsorption (Guest Lecturer: Larry Unsworth, Ph.D, National Institute for Nanotechnology)
Crystallography (Guest lecturer: Liselotte Kaiser, MIT Center for Biomedical Engineering) |
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| 20 |
DNA Molecular Machines |
Take-home midterm exam due |
| 21 |
Fluorescent Proteins |
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| 22 |
Self-assembling Peptide Systems (Dr. Zhang's Research) |
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| 23 |
Self-assembling Peptide Systems (Dr. Zhang's Research) (cont.)
Applying Biomimicry to Nanotechnology (Guest Lecture by Andreas Mershin) |
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| 24 |
Research in Biomaterials |
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| 25-26 |
Student Research Activity Presentations |
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