| 1 |
Overview of Course, Orientation to Current Approaches and Types of Molecularly-designed Biomaterials
Biodegradable Polymeric Solids
Chemistry and Physical Chemistry of Hydrolysis
Links between Materials Structure and Hydrolysis Mechanisms
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| 2 |
Biodegradable Polymeric Solids (cont.)
Factors Controlling Polymer Degradation Rates
Theory of Solid Polymer Erosion
Tailoring Degradable Polymer Structure and Composition
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Problem set 1 out |
| 3 |
Controlled Release Devices
Types of Controlled Release Devices
Degradable Materials in Controlled Release Devices
Physical Chemistry Principles in Delivering Small Molecules vs. Proteins
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| 4 |
Controlled Release Devices (cont.)
Theory of Drug Release in Eroding Systems
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Problem set 1 due
Problem set 2 out
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| 5 |
Case Studies in Complex Controlled Release
Pulsatile Release from Programmed Eroding Systems
Controlled Release Microchips
Combining Drug Delivery with Tissue Engineering
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Problem set 2 due
Problem set 3 out
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| 6 |
Hydrogels as Biomaterials
Hydrogel Structure and Physical Chemistry
Methods of Polymerization
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| 7 |
Hydrogels as Biomaterials (cont.)
Theory of Hydrogel Swelling
Physical Hydrogels
- Ionic and Hydrogen Bonding in Gels
- Association of Amphiphilic Block Copolymers
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Problem set 3 due
Problem set 4 out
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| 8 |
Hydrogels as Biomaterials (cont.)
Polyelectrolyte Hydrogels
Coacervates
Polyelectrolyte Multi-layers
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| 9 |
Hydrogels as Biomaterials (cont.)
Theory of Polyelectrolyte Gel Swelling
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Problem set 4 due
Problem set 5 out
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| 10 |
Hydrogels as Biomaterials (cont.)
Applications of Hydrogels: Molecular Imprinting
Applications of Hydrogels: Glucose-sensitive Drug Delivery
Kinetics of Drug Diffusion Through Hydrogels
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| 11 |
Engineering Biological Recognition of Biomaterials
Biological Recognition in Vivo
Protein-resistant and Cell-resistant Surfaces
Engineering Recognition of Biomaterials: Adhesion and Migration
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Problem set 5 due |
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Exam 1 |
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| 12 |
Engineering Biological Recognition of Biomaterials (cont.)
Enzymatic Recognition of Biomaterials
Cytokine Signaling from Biomaterials
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| 13 |
Engineering Biological Recognition of Biomaterials (cont.)
Mimicking Cell-cell Contacts with Surfaces
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Problem set 6 out |
| 14 |
Bioceramics and Biocomposites
Introduction to Biological Approaches to Biomineralization
Interfacial Biomineralization
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| 15 |
Bioceramics and Biocomposites (cont.)
Biological Control of Mineralization within Vesicles
Biomimetic Syntheses: Microemulsion and Micellar Reactions Organic Templating of Inorganic Biomaterials: Natural and Synthetic Approaches
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Problem set 6 due
Problem set 7 out
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| 16 |
Bioceramics and Biocomposites (cont.)
Theory of Controlled Nucleation
Bone Structure and Bone Biomimesis
Biocomposites in Device Applications and Drug Delivery
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| 17 |
Molecular Devices
Molecular Switches via Proteins and 'Smart' Polymers
- Temperature, pH, and Light-sensitive Switches
Molecular Motors
- Kinesin-based Molecular Shuttles
- ATP Synthase-based Nano-rotors
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Problem set 7 due
Problem set 8 out
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| 18 |
Nanoparticle and Microparticle Biomolecule Drug Carriers
Pro-drugs, Micelles, Liposomes, Polymerosomes, Nanoparticles, and Microparticles
Delivery of Drugs to Tissues via Systemic Circulation
Materials for Anti-Cancer Drug Delivery
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| 19 |
Nanoparticle and Microparticle Biomolecule Drug Carriers (cont.)
Barriers to Systemic / Oral Delivery and Delivery of Molecules to Tissues
'Stealth' Particles
- Theory of Protein-resistant Particles
Experimental Function of Long-circulating Carriers and PEGylated Compounds
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Problem set 8 due
Take-home exam distributed
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| Focus Topic: Integrating Biological Knowledge Into Biomaterials Design For Vaccines |
| 20 |
Basic Biology of Vaccination and Viral Infections
Rudiments of Adaptive Immunity: The Basis of Vaccination
Viral Infections
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| 21 |
Basic Biology of Vaccination and Viral Infections (cont.)
Vaccination Against Viruses: Parallels between Immunization and Infection
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| 22 |
Drug Targeting and Intracellular Drug Delivery for Vaccines
Targeting Nano-carriers and Micro-carriers to Specific Cell Types
Chemistry of Antibodies for Targeting
Pathways of Intracellular Transport
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| 23 |
Drug Targeting and Intracellular Drug Delivery for Vaccines (cont.)
Mechanisms of Intracellular Delivery
Mimicking Viral Entry Strategies
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| 24 |
DNA Vaccines
Gene Therapy and DNA Immunization
Mechanisms of DNA Vaccines
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| 25 |
DNA Vaccines (cont.)
Delivery Systems for DNA
Systemic vs. Local Delivery
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Take-home exam due |