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| LEC # |
TOPICS |
SLIDES |
ANNOTATED |
| 1 |
Overview of Course, Orientation to Current Approaches and Types of Molecularly-designed Biomaterials
Biodegradable Polymeric Solids
Chemistry and Physical Chemistry of Hydrolysis
Links between Materials Structure and Hydrolysis Mechanisms
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(PDF - 1.6 MB) |
(PDF - 1.7 MB)# |
| 2 |
Biodegradable Polymeric Solids (cont.)
Factors Controlling Polymer Degradation Rates
Theory of Solid Polymer Erosion
Tailoring Degradable Polymer Structure and Composition
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(PDF) |
(PDF)# |
| 3 |
Controlled Release Devices
Types of Controlled Release Devices
Degradable Materials in Controlled Release Devices
Physical Chemistry Principles in Delivering Small Molecules vs. Proteins
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(PDF) |
(PDF)# |
| 4 |
Controlled Release Devices (cont.)
Theory of Drug Release in Eroding Systems
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(PDF) |
(PDF - 1.1 MB)# |
| 5 |
Case Studies in Complex Controlled Release
Pulsatile Release from Programmed Eroding Systems
Controlled Release Microchips
Combining Drug Delivery with Tissue Engineering
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| 6 |
Hydrogels as Biomaterials
Hydrogel Structure and Physical Chemistry
Methods of Polymerization
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(PDF - 2.0 MB) |
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| 7 |
Hydrogels as Biomaterials (cont.)
Theory of Hydrogel Swelling
Physical Hydrogels
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(PDF) |
(PDF)# |
| 8 |
Hydrogels as Biomaterials (cont.)
Polyelectrolyte Hydrogels
Coacervates
Polyelectrolyte Multi-layers
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(PDF) |
(PDF)# |
| 9 |
Hydrogels as Biomaterials (cont.)
Theory of Polyelectrolyte Gel Swelling
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(PDF - 1.1 MB) |
(PDF - 1.2 MB)# |
| 10 |
Hydrogels as Biomaterials (cont.)
Applications of Hydrogels: Molecular Imprinting
Applications of Hydrogels: Glucose-sensitive Drug Delivery
Kinetics of Drug Diffusion through Hydrogels
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(PDF - 1.1 MB) |
(PDF - 1.2 MB)# |
| 11 |
Engineering Biological Recognition of Biomaterials
Biological Recognition in Vivo
Protein-resistant and Cell-resistant Surfaces
Engineering Recognition of Biomaterials: Adhesion and Migration
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(PDF - 2.3 MB) |
(PDF - 1.8 MB)# |
| 12 |
Engineering Biological Recognition of Biomaterials (cont.)
Enzymatic Recognition of Biomaterials
Cytokine Signaling from Biomaterials
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(PDF - 1.8 MB) |
(PDF - 2.0 MB)# |
| 13 |
Engineering Biological Recognition of Biomaterials (cont.)
Mimicking Cell-cell Contacts with Surfaces
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(PDF - 2.9 MB) |
(PDF - 3.4 MB)# |
| 14 |
Bioceramics and Biocomposites
Introduction to Biological Approaches to Biomineralization
Interfacial Biomineralization
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(PDF - 1.6 MB) |
(PDF - 2.2 MB)#
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| 15 |
Bioceramics and Biocomposites (cont.)
Biological Control of Mineralization within Vesicles
Biomimetic Syntheses: Microemulsion and Micellar Reactions Organic Templating of Inorganic Biomaterials: Natural and Synthetic Approaches
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(PDF) |
(PDF - 1.7 MB)# |
| 16 |
Bioceramics and Biocomposites (cont.)
Theory of Controlled Nucleation
Bone Structure and Bone Biomimesis
Biocomposites in Device Applications and Drug Delivery
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(PDF - 1.0 MB) |
(PDF - 2.2 MB)# |
| 17 |
Molecular Devices
Molecular Switches via Proteins and 'Smart' Polymers
Molecular Motors
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(PDF - 1.4 MB) |
(PDF - 1.5 MB)# |
| 18 |
Nanoparticle and Microparticle Biomolecule Drug Carriers
Pro-drugs, Micelles, Liposomes, Polymerosomes, Nanoparticles, and Microparticles
Delivery of Drugs to Tissues via Systemic Circulation
Materials for Anti-Cancer Drug Delivery
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(PDF - 4.1 MB) |
(PDF - 4.6 MB)# |
| 19 |
Nanoparticle and Microparticle Biomolecule Drug Carriers (cont.)
Barriers to Systemic / Oral Delivery and Delivery of Molecules to Tissues
'Stealth' Particles
Experimental Function of Long-circulating Carriers and PEGylated Compounds
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(PDF - 2.0 MB) |
(PDF - 2.2 MB)# |
| Focus Topic: Integrating Biological Knowledge Into Biomaterials Design For Vaccines |
| 20 |
Basic Biology of Vaccination and Viral Infections
Rudiments of Adaptive Immunity: The Basis of Vaccination
Viral Infections
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(PDF) |
(PDF - 1.3 MB)# |
| 21 |
Basic Biology of Vaccination and Viral Infections (cont.)
Vaccination Against Viruses: Parallels between Immunization and Infection
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(PDF) |
(PDF - 1.5 MB)# |
| 22 |
Drug Targeting and Intracellular Drug Delivery for Vaccines
Targeting Nano-carriers and Micro-carriers to Specific Cell Types
Chemistry of Antibodies for Targeting
Pathways of Intracellular Transport
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(PDF) |
(PDF)# |
| 23 |
Drug Targeting and Intracellular Drug Delivery for Vaccines (cont.)
Mechanisms of Intracellular Delivery
Mimicking Viral Entry Strategies
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(PDF - 2.8 MB) |
(PDF - 3.1 MB)# |
| 24 |
DNA Vaccines
Gene Therapy and DNA Immunization
Mechanisms of DNA Vaccines
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(PDF - 4.1 MB) |
(PDF - 4.7 MB)# |
| 25 |
DNA Vaccines (cont.)
Delivery Systems for DNA
Systemic vs. Local Delivery
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