The lecture notes linked below are from the Fall 2003 version of this course. The lecture notes were created by Prof. King unless otherwise noted.
Lecture notes files.
| SES # |
TOPICS |
LECTURE NOTES |
| 1 |
Introduction to the problem |
(PDF) |
| 2 |
Side-chain review
Sulfur redox chemistry
|
|
| 3 |
The Anfinsen experiments |
(PDF) |
| 4 |
Globular protein structure
Protein interiors
|
(PDF) |
| 5 |
Using the Protein database (PDB) |
(PDF - 2.5 MB) (Courtesy of Prof. David Gossard) |
| 6 |
Helix-helix packing in globular proteins |
(PDF) |
| 7 |
Beta-sheets
Beta-sheet packing
|
(PDF) |
| 8 |
Experimental techniques: circular dichroism |
|
| 9 |
Thermal denaturation
Coiled coils
Refolding of tropomyosin
|
(PDF 1) (Courtesy of Prof. David Gossard)
(PDF 2)
|
| 10 |
Fluorescence spectroscopy |
|
| 11 |
S-peptide helical folding |
(PDF) |
| 12 |
Detecting partially folded intermediates |
(PDF) |
| 13 |
Prolyl isomerization |
|
| 14 |
Cytochrome c refolding pathway |
(PDF) |
| 15 |
2-D NMR techniques |
|
| 16 |
Collagen structure and folding in vivo |
(PDF - 1.8 MB) (Courtesy of Prof. David Gossard) |
| 17 |
Procollagen folding in vitro |
|
| 18 |
Protein calorimetry: BPTI |
|
| 19 |
Protein misfolding and aggregation |
(PDF) |
| 20 |
Ribosome channel
Nascent chains
Trigger factor
|
(PDF) |
| 21 |
Scaffolding proteins in viral shell assembly |
|
| 22 |
Amyloid fiber formation in neuro degenerative disease |
|
| 24 |
Chaperonin assisted folding |
(PDF) |
| 25 |
Eukariotic chaperonins |
|
| 26 |
Paper topic discussion and choices |
|
| 27 |
Membrane protein (rhodopsin) folding and assembly |
|
| 28 |
Prion diseases |
|
| 29 |
Etiology of some human protein deposition diseases |
|