| 1 |
Ion channels I |
Chapters 5 and 7 |
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| 2 |
Ion channels II |
Chapters 5 and 7 |
Choe, Senyon. "Potassium Channel Structures." Neuroscience 3 (February 2002): 115-121.
Grottesi, Alessandro, Zara A. Sands, and Mark S. P. Sansom. "Potassium Channels: Complete and Undistorted." Current Biology 15, no. 18 (September 20, 2005): R771-R774.
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| 3 |
Receptors I |
Chapters 11 and 12 |
Lefkowitz, Robert J. "Historical Review: A Brief History and Personal Retrospective of Seven-transmembrane Receptors." TRENDS in Pharmacological Sciences 25, no. 8 (August 2004): 413-422.
Strader, Catherine D., Tung Ming Fong, Michael R. Tota, and Underwood Dennis. "Structure and Function of G Protein-coupled Receptors." Annu Rev Biochem 63 (1994): 101-32.
Gainetdinov, Raul R., Richard T. Premont, Laura M. Bohn, et al. "Desensitization of G Protein–coupled Receptors and Neuronal Functions." Annu Rev Neurosci 27 (2004):107-44.
Clapham, David E. "TRP Channels as Cellular Sensors." Nature 426, no. 4 (December 2003): 517-524.
Ashmore, Jonathan. "Channel at the Hair's End." Nature 432, no. 9 (December 2004): 685-686.
Barritt, Greg Barritt, and Grigori Rychkov. "TRPs as Mechanosensitive Channels." Nature Cell Biology 7, no. 2 (February 2005): 105-107.
Corey, David P. "What is the Hair Cell Transduction Channel?" J Physiol 576, no. 1 (2006): 23-28.
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| 4 |
Receptors II |
Chapters 11 and 12 |
Lefkowitz, Robert J, and Erin J Whalen. "β-Arrestins: Traffic Cops of Cell Signaling." Current Opinion in Cell Biology 16 (2004): 162-168.
Shenoy, Sudha K., Patricia H. McDonald, Trudy A. Kohout, et al. "Regulation of Receptor Fate by Ubiquitination of Activated β2 -Adrenergic Receptor and β-Arrestin." Science 294, no. 9 (November 2001): 1307-1313.
Gilman, Alfred G. "G Proteins and Regulation of Adenylyl Cyclase." Bioscience Reports 15, no. 2 (April 1995): 65-97.
Neer, Eva J. "Heterotrimeric G Proteins: Review Organizers of Transmembrane Signals." Cell 80 (January 27, 1995): 249-257.
Pierce, Kristen L., Richard T. Premont, and Robert J Lefkowitz. "Seven-Transmembrane Receptors." Molecular Cell Biology 3 (September 2002): 639-650.
von Zastrow, Mark, et al. "Regulated Endocytosis of Opioid Receptors: Cellular Mechanisms and Proposed Roles in Physiological Adaptation to Opiate Drugs." Current Opinion in Neurobiology 13 (2003): 348-353.
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| 5 |
Introduction; basics of electrophysiology |
Chapters 1 and 4 |
Nowak L., P. Bregestovski, and P. Ascher. "Magnesium Gates Glutamate-activated Channels in Mouse Central Neurons." Nature 307 (February 1984): 462-465. |
| 6 |
Modulation of receptor activity |
Chapter 13, pp. 315-331 |
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| 7 |
Protein targeting, signaling complexes |
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| 8 |
Neuronal polarity / subcellular specialization |
Chapter 2 |
Jiang, Hui, Guo, Wei, Liang, Xinhua, et al. "Both the Establishment and the Maintenance of Neuronal Polarity Require Active Mechanisms: Critical Roles of GSK-3β and Its Upstream Regulators." Cell 120 (January 14, 2005): 123-135.
Ye, Bing, et al. "Growing Dendrites and Axons Differ in Their Reliance on the Secretory Pathway." Cell 130 (August 24, 2007): 717-729.
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| 9 |
Repertoire of neuron interactions |
Chapters 2, 3, 8, and 16, pp. 395-406 |
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| 10 |
Neurogenesis |
Chapter 15 |
Buchman, Joshua J., and Li-Huei Tsai. "Spindle Regulation in Neural Precursors of Flies and Mammals." Neuroscience 8 (February 2007): 89-100.
Ayala, Ramsés, Tianzhi Shu, and Li-Huei Tsai. "Trekking across the Brain: The Journey of Neuronal Migration." Cell 128 (January 12, 2007): 29-43.
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| 11 |
Presynaptic mechanisms |
Chapter 9 |
Jahn, Reinhard, Thorsten Lang, and Thomas C. Sudhof. "Membrane Fusion." Cell 112 (February 21, 2003): 519-533.
Rizo, Josep, and Thomas C. Sudhof. "Snares and Munc18 in Synaptic Vesicle Fusion." Neuroscience 3 (August 2002): 641-653.
Edwards, Robert H. "The Neurotransmitter Cycle and Quantal Size." Neuron 55 (September 20, 2007): 835-858.
Galli, Thierry, and Volker Haucke. "Cycling of Synaptic Vesicles: How Far? How Fast!" Sci STKE, no. 88 (June 26, 2001): 1-10.
Stevens, Charles F. "Neurotransmitter Release at Central Synapses." Neuron 40 (October 9, 2003): 381-388.
Yoshihara, Motojiro, Bill Adolfsen, and Troy J. Littleton. "Is Synaptotagmin the Calcium Sensor?" Current Opinion in Neurobiology 13 (2003): 315-323.
Koh, Tong-Wey Koh, and Hugo J. Bellen. "Synaptotagmin I, a Ca2+ sensor for Neurotransmitter Release." TRENDS in Neurosciences 26, no. 8 (August 2003): 413-422.
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Mid-term exam |
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| 12 |
Molecular manipulation of neural circuits |
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Tervo, Dougal, and Alla Y. Karpova. "Rapidly Inducible, Genetically Targeted Inactivation of Neural and Synaptic Activity In vivo." Current Opinion in Neurobiology 17 (2007): 581-586. |
| 13 |
Axon guidance |
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Tessier-Lavigne, Marc, and Corey S. Goodman. "The Molecular Biology of Axon Guidance." Science 274, no. 5290 (November 15, 1996): 1123-1133. |
| 14 |
Synapse formation/elimination |
Chapter 18 |
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| 15 |
Trophic factors |
Chapter 16, pp. 408-427 |
Chao, Moses V. "Neurotrophins and their Receptors: A Convergence Point for many Signaling Pathways." Neuroscience 4 (April 2003): 299-309. |
| 16 |
Postsynaptic mechanisms; LTP/LTD |
Chapter 20, pp. 558-570 |
Sheng, Morgan, et al. "Postsynaptic Signaling and Plasticity Mechanisms." Science 298 (October 25, 2002): 776-780.
Merrill, Michelle A., Yucui Chen, Stefan Strack, et al. "Activity-driven Postsynaptic Translocation of CaMKII." TRENDS in Pharmacological Sciences 26, no. 12 (December 2005): 645-653.
Malenka, Robert C., and Mark F. Bear. "LTP and LTD: An Embarrassment of Riches." Neuron 44 (September 30, 2004): 5-21.
Malenka, Robert C. "The Long-term Potential of LTP." Neuroscience 4 (November 2003): 923-926.
Renger, John J., Christophe Egles, and Guosong Liu. "A Developmental Switch in Neurotransmitter Flux Enhances Synaptic Efficacy by Affecting AMPA Receptor Activation." Neuron 29 (February 2001): 469-484.
Kelleher, Raymond J., Arvind Govindarajan, and Susumu Tonegawa. "Translational Regulatory Mechanisms in Persistent Forms of Synaptic Plasticity." Neuron 44 (September 30, 2004): 59-73.
Frey, Uwe, and Richard G. M. Morris. "Synaptic Tagging: Implications for Late Maintenance of Hippocampal Long-term Potentiation." TINS 21, no. 5 (1998): 181-188.
Martin, Kelsey C., and Kenneth S. Kosik. "Synaptic Tagging - Who's it?" Neuroscience 3 (October 2002): 813-820.
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| 17 |
Waves and chemoaffinity |
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Wilkinson, David G. "Multiple Roles of EPH Receptors and Eprins in Neural Development." Neuroscience 2 (March 2001): 155-164.
Feldheim, David A., Young-In Kim, and Andrew D. Bergeman, et al. "Genetic Analysis of Ephrin-A2 and Ephrin-A5 Shows Their Requirement in Multiple Aspects of Retinocollicular Mapping." Neuron 25 (March 2000): 563-574.
Klein, Rüdiger. "Excitatory Eph Receptors and Adhesive Ephrin Ligands." Current Opinion in Cell Biology 13 (2001): 196-203.
Simon, David K., and Dennis D. M. O'Leary. "Development of Topographic Order in the Mammalian Retinocollicular Projection." The Journal of Neuroscience 12, no. 4 (April 1992): 1212-1232.
Simon, David K., Glen T. Pruskyt, Dennis D. M. O'Leary, et al. "N-Methyl-D-Aspartate Receptor Antagonists Disrupt the Formation of a Mammalian Neural Map." Proc Natl Acad Sci 89 (November 1992): 10593-10597.
Zhou, Jimmy Z. "Direct Participation of Starburst Amacrine Cells in Spontaneous Rhythmic Activities in the Developing Mammalian Retina." The Journal of Neuroscience 18, no. 11 (June 1, 1998): 4155-4165.
Butts, Daniel A. "Retinal Waves: Implications for Synaptic Learning Rules during Development." The Neuroscientist 8, no. 3 (2002): 243-253.
Butts, Daniel A., and Daniel S. Rokhsar. "The Information Content of Spontaneous Retinal Waves." The Journal of Neuroscience 21, no. 3 (February 1, 2001): 961-973.
Söhl, Goran, Stephan Maxeiner, and Klaus Willecke. "Expression and Functions of Neuronal Gap Junctions." Neuroscience 6 (March 2005): 191-200.
Torborg, Christine L, Kristi A Hansen, and Marla B Feller. "High Frequency, Synchronized Bursting Drives Eye-specific Segregation of Retinogeniculate Projections." Nature Neuroscience 8, no. 1 (January 2005): 72-78.
Mann, Fanny, William A. Harris, and Christine E. Holt. "New Views on Retinal Axon Development: A Navigation Guide." Int J Dev Biol 48 (2004): 957-964.
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| 18 |
Two faces of GABA |
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Owens, David F., and Arnold R. Kriegstein. "Is There More to Gaba than Synaptic Inhibition?" Neuroscience 3 (September 2002): 715-727. |
| 19 |
Hodgkin and Huxley (lecture 1) |
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Hodgkin, A. L., A. F. Huxley, and B. Katz. "Measurement of Current-voltage Relations in the Membrane of the Giant Axon of Loligo." J Physiol 116 (1952): 424-448.
Hodgkin, A. L., and A. F. Huxley. "Currents Carried by Sodium and Potassium Ions through the Membrane of the Giant Axon of Loligo." J Physiol 116 (1952): 449-472.
———. "The Components of Membrane Conductance in the Giant Axon of Loligo." J Physiol 116 (1952): 473-496.
———. "The Dual Effect of Membrane Potential on Sodium Conductance in the Giant Axon of Loligo." J Physiol 116 (1952): 497-506.
———. "A Quantitative Description of Membrane Current and Its Application to Conduction and Excitation in Nerve." J Physiol 117 (1952): 500-544.
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| 20 |
Hodgkin and Huxley (lecture 2) |
Chapters 19 and 20 |
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| 21 |
Aplysia learning |
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Bailey, Craig H., Eric R. Kandel, and Kausik Si. "The Persistence of Long-term Memory: A Molecular Approach to Self-sustaining Changes in Learning-induced Synaptic Growth." Neuron 44 (September 30, 2004): 49-57. |
| 22 |
Drosophila learning |
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Keene, Alex C., and Scott Waddell. "Drosophila Olfactory Memory: Single Genes to Complex Neural Circuits." Neuroscience 8 (May 2007): 341-354. |
| 23 |
Drosophila circadian rhythms |
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Nitabach, Michael N., and Paul H. Taghert. "Organization of the Drosophila Circadian Control Circuit." Current Biology 18, no. 2 (January 22, 2008): R84-R93. |
| 24 |
Epilepsy |
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Steinlein, Ortrud K. "Genetic Mechanisms that Underlie Epilepsy." Neuroscience 5 (May 2004): 400-408. |
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Final exam |
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