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Required Text
[S&K] Shuler, Michael L., and Fikret Kargi. Bioprocess Engineering: Basic Concepts. 2nd ed. Upper Saddle River, NJ: Prentice Hall PTR, 2001. ISBN: 9780130819086.
Additional Resources
Blanch, Harvey W., and D. S. Clark, eds. Biochemical Engineering. New York, NY: Marcel Dekker Incorporated, 1997. ISBN: 9780824700997.
Bailey, James E., and David F. Ollis. Biochemical Engineering Fundamentals. New York, NY: McGraw-Hill Education, 1986. ISBN: 9780070666016.
Rozzell, J. D. "Commercial scale biocatalysis: myths and realities." Bioorg Med Chem 7, no. 10 (October 1999): 2253-61.
Course readings.
| SES # |
TOPICS |
READINGS |
| 1 |
Course Overview, Enzyme Classification |
S&K. Chapter 1. |
| 2 |
Enzyme Kinetics (Single-substrate Reactions), Measurement |
S&K. Chapter 3.1-3.3.3. |
| 3 |
Enzyme Inhibition |
S&K. Chapter 3.3.4. |
| 4 |
Enzyme Inhibition, pH and Temp Effects |
S&K. Chapter 3.3.5. |
| 5 |
Non-ideal Enzyme Kinetics |
Class notes |
| 6 |
Immobilized Enzyme Kinetics - External |
S&K. Chapter 3.4. |
| 7 |
Immobilized Enzyme Kinetics - Internal |
S&K. Chapter 3.4. |
| 8 |
Applications of Enzyme Catalysis (Biocatalysis) |
S&K. Chapter 3.5, 3.6.
Handouts |
| 9 |
Microbial Growth |
S&K. Chapter 6.1-6.2. |
| 10 |
Microbial Growth - Batch Cultivation Profiles |
S&K. Chapter 6.1-6.2. |
| 11 |
Stoichiometry of Growth, Product Formation |
S&K. Chapter 7. |
| 12 |
Stoichiometry of Growth, Product Formation (cont.) |
S&K. Chapter 7. |
| 13 |
Models of Microbial Growth |
S&K. Chapter 6.3. |
| 14 |
Models of Microbial Growth (cont.) |
S&K. Chapter 6.3. |
| 15 |
Continuous Culture |
S&K. Chapter 6.4. |
| 16 |
Continuous Culture (cont.) |
S&K. Chapter 6.4. |
| 17 |
Bioreactor Design |
S&K. Chapter 9.1-9.3. |
| 18 |
Bioreactor Design (cont.) |
S&K. Chapter 9.1-9.3. |
| 19 |
Bioreactor Design (cont.) |
|
| 20 |
Mass Transfer |
S&K. Chapter 6.2.3-6.2.4, 10.2.3. |
| 21 |
Mass Transfer (cont.) |
S&K. Chapter 6.2.3-6.2.4, 10.2.3. |
| 22 |
Heat Transfer, Media and Air Sterilization |
S&K. Chapter 10.4. |
| 23 |
Scale-up |
S&K. Chapter 10.2.4. |
| 24 |
Scale-down |
S&K. Chapter 10.2.5. |
| 25 |
Animal Cell Culture |
S&K. Chapter 12. |
| 26 |
Animal Cell Culture (cont.) |
S&K. Chapter 12. |
| 27 |
Mixed Cultures |
S&K. Chapter 16. |
| 28 |
Mixed Cultures (cont.) |
S&K. Chapter 16. |
| 29 |
Medium Development |
Handouts |
| 30 |
Medium Development (cont.) |
Handouts |
| 31 |
Cellular Engineering - An Engineer's View Towards Recombinant Organisms |
S&K. Chapter 14.
Handouts |
| 32 |
Cellular Engineering/Molecular Biology for Process Engineering |
S&K. Chapter 14.
Handouts |
| 33 |
Cellular Engineering/Molecular Biology for Process Engineering (cont.) |
S&K. Chapter 14.
Handouts |
| 34 |
Enzyme Engineering for Process Improvement |
Handouts |
| 35 |
Enzyme Engineering for Process Improvement (cont.) |
Handouts |