| 1 |
Strategies for Biochemical Process Synthesis |
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| 2 |
Biochemical Processing Overview |
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| 3 |
Cell Disruption |
 Shutte, H., and M. R. Kula. "Cell Disruption and Isolation of Non-Secreted Products." In Biotechnology: A Multi-Volume Comprehensive Treatise. Vol. 3, Bioprocessing. Edited by G. Stephanopoulos. New York, NY: VCH Publishers, Inc., 1993, pp. 505-526. ISBN: 9783527283132. |
| 4 |
Solid-Liquid Separation: Centrifugation |
Datar, R. V., and C. G. Rosen. "Cell and Cell Debris Removal: Centrifugation and Crossflow Filtration." In Biotechnology: A Multi-Volume Comprehensive Treatise. Vol. 3, Bioprocessing. Edited by G. Stephanopoulos. New York, NY: VCH Publishers, Inc., 1996, pp. 469-486. ISBN: 9783527283132. |
| 5 |
Chromatography |
Palmer, D. E., and R. V. Dove. "Ion Exchange Recovery of Proteins." In Comprehensive Biotechnology. Vol. 2, The Principles of Biotechnology: Engineering Considerations. Edited by C. L. Cooney, and A. E. Humphrey. Elmsford, NY: Pergamon Press Ltd., 1985, pp. 481-488. ISBN: 008032510.
Yarmush, M. L., K. Antonsen, and D. M. Yarmush. "Molecular Sieve Chromatography." In Comprehensive Biotechnology. Vol. 2, The Principles of Biotechnology: Engineering Considerations. Edited by C. L. Cooney, and A. E. Humphrey. Elmsford, NY: Pergamon Press Ltd., 1985, pp. 489-505. ISBN: 008032510.
Skoog, D. A., D. M. West, and F. J. Holler. "An Introduction to Chromatographic Methods." In Fundamentals of Analytical Chemistry. New York, NY: Saunders College Publishing, 1992, pp. 665-693. ISBN: 9780030749223. |
| 6 |
Protein Refolding |
Cleland, J. L., and D. I. C. Wang. "In vitro Protein Refolding." In Biotechnology: A Multi-Volume Comprehensive Treatise. Vol. 3, Bioprocessing. Edited by G. Stephanopoulos. New York, NY: VCH Publishers, Inc., 1996, pp. 527-555. ISBN: 9783527283132.
Datar, R. V., T. Cartwright, and C. G. Rosen. "Process Economics of Animal Cell and Bacterial Fermentations - A Case Study Analysis of Tissue Plasminogen Activator." Bio/Technology 11, no. 3 (1993) 349-357. |
| 7 |
Solid-Liquid Separation: Filtration |
Ladisch, M. R. "Filtration." In Bioseparations Engineering: Principles, Practice, and Economics. New York, NY: John Wiley and Sons, 2001, pp. 36-47. ISBN: 9780471244769. |
| 8 |
Membrane and Filtration Applications |
Datar, R. V., and C. G. Rosen. "Cell and Cell Debris Removal: Centrifugation and Crossflow Filtration." In Biotechnology: A Multi-Volume Comprehensive Treatise. Vol. 3, Bioprocessing. Edited by G. Stephanopoulos. New York, NY: VCH Publishers, Inc., 1996, pp. 487-503. ISBN: 9783527283132.
Tutunjian, R. S. "Ultrafiltration Processes in Biotechnology." In Comprehensive Biotechnology. Vol. 2, The Principles of Biotechnology: Engineering Considerations. Edited by C. L. Cooney, and A. E. Humphrey. Elmsford, NY: Pergamon Press Ltd., 1985, pp. 411-437. ISBN: 008032510. |
| 9 |
Rotary Vacuum Filtration |
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| 10 |
Process Synthesis, Analysis and Simulation |
Shuler, M. L., and F. Kargi. "Separation of Soluble Products." In Bioprocess Engineeing. Englewood Cliffs, NJ: Prentice Hall PTR, 1991, pp. 325-331. ISBN: 9780134782157.
Kelly, B. D., and T. A. Hatton. "Protein Purification by Liquid-Liquid Extraction." In Biotechnology: A Multi-Volume Comprehensive Treatise. Vol. 3, Bioprocessing. Edited by G. Stephanopoulos. New York, NY: VCH Publishers, Inc., 1996, pp. 593-616. ISBN: 9783527283132. |
| 11 |
Process Simulation |
Petrides, D., C. L. Cooney, and L. B. Evans. "An Introduction to Biochemical Process Design." In Chemical Engineering Problems in Biotechnology. Edited by M. L. Shuler. New York, NY: American Institute of Chemical Engineers, 1989, pp. 351-391. ISBN: 9780816904693.
Ernst, S., et al. "Process Simulation for Recombinant Protein Production: Cost Estimation and Sensitivity Analysis for Heparinase I Expressed in Escherichia Coli." Biotechnology and Bioengineering 53, no. 6 (1997): 575-582. |
| 12 |
Case Study in Innovation |
Bioprocess Design and Simulation Handout (PDF) (Courtesy of Steve Griffiths, PhD. Used with permission.)
Insulin Case Study
Ladisch, M. R., and K. L. Kohlmann. "Recombinant Human Insulin." Biotechnology Progress 8, no. 6 (1992): 469-478.
Petrides, D., E. Sapidou, and J. Calandranis. "Computer-Aided Process Analysis and Economic-Evaluation for Biosynthetic Human Insulin Production - A Case Study." Biotechnology and Bioengineering 48, no. 5 (1995): 529-541. |
| 13 |
Process Validation |
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