Course Features
Course Highlights
This course features a complete set of homework and recitation assignments in the
assignments and
recitations sections. In addition, a partial set of lecture notes is available in the
lecture notes section.
Course Description
This course focuses on the algorithmic and machine learning foundations of computational biology, combining theory with practice. We study the principles of algorithm design for biological datasets, and analyze influential problems and techniques. We use these to analyze real datasets from large-scale studies in genomics and proteomics. The topics covered include:
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Genomes: Biological Sequence Analysis, Hidden Markov Models, Gene Finding, RNA Folding, Sequence Alignment, Genome Assembly.
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Networks: Gene Expression Analysis, Regulatory Motifs, Graph Algorithms, Scale-free Networks, Network Motifs, Network Evolution.
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Evolution: Comparative Genomics, Phylogenetics, Genome Duplication, Genome Rearrangements, Evolutionary Theory, Rapid Evolution.
Technical Requirements
Special software is required to use some of the files in this course: .py.