| D1 |
Organizational Meeting |
|
| L1 |
Introduction |
Chapter 1 |
| R1 |
Scheme Review and Matching |
|
| L2 |
Search |
Chapter 3 (Sec 3.1-3.5) |
| D2 |
Introduction to Diagnostic Reasoning |
Szolovits, P., and S. G. Pauker. "Categorical and probabilistic reasoning in medical diagnosis." Artificial Intelligence 11, nos. 1-2 (1978): 115-144.
Pauker, S. G., G. A. Gorry, J. P. Kassirer, and W. B. Schwartz. "Toward the Simulation of Clinical Cognition: Taking the Present Illness." American Journal of Medicine 60 (1976): 1-18. |
| L3 |
Search (cont.) |
Chapter 4 (Sec 4.1-4.3) |
| R2 |
Searches |
|
| L4 |
Constraint Satisfaction |
Chapter 5 |
| D3 |
Diagnosis by Pattern Matching and Search |
Wu, T. D. "Efficient Diagnosis of Multiple Disorders Based on a Symptom Clustering Approach." In Proceedings of the Eighth National Conference on Artificial Intelligence. Menlo Park, CA: AAAI Press, 1990, pp. 357-364.
 Pople, H. E., Jr. "Heuristic Methods for Imposing Structure on Ill-Structured Problems: The Structuring of Medical Diagnostics." Chapter 5 in Artificial Intelligence in Medicine. Edited by P. Szolovits. Boulder, CO: Westview Press, 1982, pp. 119-190. ISBN: 9780891589006. |
| L5 |
Games |
Chapter 6 (Sec 6.1-6.3) |
| R3 |
CSP and Games |
|
| L6 |
Learning as Search |
|
| D4 |
Causal Reasoning |
Schwartz, W. B., R. S. Patil, and P. Szolovits. "Artificial intelligence in medicine: where do we stand." New England Journal of Medicine 316 (1987): 685-688.
Patil, R. S., P. Szolovits, and W. B. Schwartz. "Causal understanding of patient illness in medical diagnosis." In Proceedings of the Seventh International Joint Conference on Artificial Intelligence, 1981, pp. 893-899.
———. "Information acquisition in diagnosis." In Proceedings of the National Conference on Artificial Intelligence. American Association for Artificial Intelligence, 1982, pp. 345-348.
Patil, R. S. "Causal Representation of Patient Illness for Electrolyte and Acid-Base Diagnosis." MIT Ph.D. Thesis, 1981. |
| L7 |
Formulating Search |
|
| R4 |
Design Project 1 |
|
| L8 |
Decision Trees |
Chapter 18 (Sec 18.1-18.3) |
| D5 |
Receiver-Operator Characteristics Curves to Evaluate Systems |
Lasko, T. A., J. G. Bhagwat, K. H. Zou, and L. Ohno-Machado. The Use of Receiver Operating Characteristic Curves in Biomedical Informatics. (In press.) |
| L9 |
Naïve Bayes |
Chapter 18 (Sec 18.1-18.3) |
| R5 |
Design Project 1 Presentation and Question-Answer |
|
| Q1 |
Quiz 1 |
|
| D6 |
Prognostic Modeling |
Cooper, Gregory F., et al. "Predicting Dire Outcomes of Patients with Community Acquired Pneumonia." Journal of Biomedical Informatics 38, no. 5 (2005): 347-366. |
| L10 |
Continuous Features |
Chapter 20 (Sec 20.4) |
| R6 |
Naïve Bayes and Nearest Neighbor |
|
| L11 |
Linear Separators |
Chapter 20 (Sec 20.5-20.6) |
| D7 |
Classification Methods for Gene Expression Data |
Statnikov, A., et al. "A comprehensive evaluation of multicategory classification methods for microarray gene expression cancer diagnosis." Bioinformatics 21, no. 5 (2005): 631-643.
Kuo, W. P., et al. "A primer on gene expression and microarrays for machine learning researchers." Journal of Biomedical Informatics 37 (2004): 293–303. |
| L12 |
Neural Nets |
Chapter 20 (Sec 20.5-20.6) |
| R7 |
SVM |
|
| L13 |
SVM |
Chapter 20 (Sec 20.5-20.6) |
| D8 |
Predictive Models |
Marcin, J. P., et al. "Combining physician's subjective and physiology-based objective mortality risk predictions." Crit Care Med 28, no. 8 (2000): 2984-90.
Steyerberg, E. W., et al. "Validation and updating of predictive logistic regression models: a study on sample size and shrinkage." Statist Med 23 (2004): 2567-2586. |
| L14 |
Feature and Model Selection |
Chapter 20 (Sec 20.5-20.6) |
| R8 |
Problem Set 6 |
|
| Q2 |
Quiz 2 |
|
| D9 |
Learning Medical Reasoning |
Coderre, S., et al. "Diagnostic reasoning strategies and diagnostic success." Medical Education 37 (2003): 695-703.
Arocha, J. F., et al. "Identifying reasoning strategies in medical decision making: A methodological guide." Journal of Biomedical Informatics (2005 - in press.) |
| L15 |
Formulating Learning |
|
| R9 |
Introduction to Logic |
|
| L16 |
Introduction to Logic and Representation |
|
| D10 |
Pragmatics |
Hunt, D. L., et al. "Effects of Computer-Based Clinical Decision Support Systems on Physician Performance and Patient Outcomes." JAMA 280, no. 15 (1998): 1339-46.
Kawamoto, K., et al. "Improving clinical practice using clinical decision support systems: a systematic review of trials to identify features critical to success." BMJ (British Medical Journal) 330, no. 7494 (2005): 765.
Ammenwerth, E., and N. de Keizer. "An Inventory of Evaluation Studies of Information Technology in Health Care." Methods Inf Med 44 (2005): 44-56.
Nielsen, J. "Medical Usability: How to Kill Patients Through Bad Design." |
| L17 |
Propositional Logic |
Chapter 7 (Sec 7.1-7.5) |
| R10 |
Design Project 2 Presentation and Question-Answer |
|
| D11 |
Medical Knowledge Representation |
Rector, A. L., et al. "The GRAIL Concept Modelling Language for Medical Terminology." Extended version of the paper in Artificial Intelligence in Medicine 9 (1997): 139-171.
Trombert-Paviot, B., et al. "GALEN: a third generation terminology tool to support a multipurpose national coding system for surgical procedures." International Journal of Medical Informatics 58-59 (2000): 71-85. |
| L18 |
Introduction to Natural Language Processing |
|
| R11 |
Logic and Proof |
|
| L19 |
First Order Logic |
Chapter 8 (Sec 8.1-8.3) |
| D12 |
Evaluation of Complex Decision Support Systems |
Berner, E. S., et al. "Performance of Four Computer-Based Diagnostic Systems." New England Journal of Medicine 300 (1994): 1792-6.
Fraser, H. S. F., et al. "Evaluation of a Cardiac Diagnostic Program in a Typical Clinical Setting." Journal of the American Medical Informatics Association 10 (2003): 373-381. |
| L20 |
First Order Logic (cont.) |
Chapter 9 (Sec 9.1, 9.2, 9.5) |
| R12 |
Syntax and Semantics |
|
| L21 |
Rules |
Chapter 9 (Sec 9.4) |
| D13 |
Rule-Based Expert Systems |
Davis, R., B. G. Buchanan, and E. H. Shortliffe. "Production Rules as a Representation for a Knowledge-Based Consultation Program." Artificial Intelligence 8 (1977): 15-45.
Yu, V. L., B. G. Buchanan, E. H. Shortliffe, S. M. Wraith, R. Davis, A. C. Scott, and S. N. Cohen. "Evaluating the Performance of a Computer-Based Consultant." Comp Programs in Biomedicine 9 (1979): 95-102.
Yu, V. L., et al. "Antimicrobial Selection by a Computer: A Blinded Evaluation by Infectious Diseases Experts." JAMA 242, no. 12 (1979): 1279-82. |
| L22 |
Language |
Chapter 22 (Sec 22.1-22.5) |
| R13 |
Problem Set 9 |
|
| L23 |
Language |
Chapter 22 (Sec 22.1-22.5) |
| D14 |
Student Presentations |
|
| L24 |
Conclusion |
|
|
Final Exam |
|