| 1 |
Course Introduction
Biomaterials Defined
Structural Hierarchy in Materials and Biology |
Whitesides, G. M., and A. P. Wong. "The Intersection of Biology and Materials Science." MRS Bulletin 31 (2006): 19-27.
Ratner: pp. 1-26, Sections 2.1, 2.2, 2.9, and 2.10. |
| 2 |
Biomaterials Surfaces: Physics
Surface (vs. Bulk) Structure and Properties
Surface Energy
Adsorption, Segregation, and Reconstruction at Surfaces |
Ratner: pp. 40-45, Section 1.5. |
| 3 |
Biomaterials Surfaces: Chemistry
Reactions at Surfaces: Chemisorption, Corrosion |
Jacobs, J. J., J. L. Gilbert, and R. M. Urban. "Corrosion of Metal Orthopaedic Implants." Journal of Bone and Joint Surgery 80A (1998): 268-282.
Ratner: Section 6.3. |
| 4 |
Biomaterials Surfaces: Chemistry (cont.)
Hydrolysis (Dr. Taniguchi) |
Ratner: pp. 411-416, Section 2.7.
Ikada, Y., and H. Tsuji. "Biodegradable Polyesters for Medical and Ecological Applications." Macromolecular Rapid Communications 21 (2000): 117-132. |
| 5 |
Protein-Surface Interactions
Proteins: Structure, Properties, Functions
Protein Adsorption: Langmuir Model |
Ratner: pp. 237-246. |
| 6 |
Protein-Surface Interactions (cont.)
Protein Adsorption: Complex Phenomena, Measurement |
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| 7 |
Cell-Surface Interactions: Host Response to Biomaterials
Cell Adhesion Mechanisms
Coagulation Cascade |
Ratner: Section 4.6. |
| 8 |
Cell-Surface Interactions: Host Response to Biomaterials (cont.)
Immune Response: Alternative Complement Activation |
Ratner: Sections 3.4, 4.2, 4.3, and 4.4. |
| 9 |
Surface Modification Methods
Purposes
Plasma Treatments
Organic Coatings (Dr. Taniguchi) |
Ratner: Sections 2.13, 2.14, 2.16, and 7.2. |
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Quiz 1 |
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| 10 |
Surface Modification Methods (cont.)
Polymer Coatings
Patterned Surfaces |
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| 11 |
Surface Characterization
In Vacuum: XPS/ESCA, AES, SIMS |
Ratner: pp. 42-57 |
| 12 |
Surface Characterization In situ
Contact Angle, AFM |
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| 13 |
Quantifying Cell Behavior
Cell Cultures
Cellular Assays: Adhesion, Migration, Proliferation |
Handouts: Principles of Biochemistry, Receptors: Models for Binding, Trafficking, and Signaling. |
| 14 |
Quantifying Cell Behavior (cont.)
Cellular Assays: Differentiation, Function |
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| 15 |
Statistical Analysis
Error Sources, Distribution Functions, t- test |
Ratner: Section 9.4.
Handout: Experimentation: An Introduction to Measurement Theory. |
| 16 |
Statistical Analysis (cont.)
Fisher Test, Regression Methods |
Marazuela, M. D., and M. C. Moreno-Bondi. "Fiber-optic Biosensors - An Overview." Analytical and Bioanalytical Chemistry 372 (2002): 664-682. |
| 17 |
Biosensors and Diagnostic Devices
Biological Elements
Transduction Mechanisms
Properties
Examples: Fiber Optic Biosensors, Nanobarcodes |
Ratner: Sections 7.17 and 7.18. |
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Quiz 2 |
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| 18 |
Drug Delivery: Controlled Release (Dr. Taniguchi)
Chemically-controlled Devices |
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| 19 |
Drug Delivery: Controlled Release (cont.)
Diffusion-controlled, Membrane-based and Osmotic Devices |
Ratner: Section 7.14.
Duncan, Ruth. "The Dawning Era of Polymer Therapeutics." Nature Reviews Drug Discovery 2 (2003): 347-360. |
| 20 |
Drug Delivery: Controlled Release (cont.)
Methods: Transdermal, Colloidal Vehicles
Mechanical Pumps |
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| 21 |
Biomaterials for Organ Replacement
Organ Replacement Therapies
Mechanical Properties
Bone Substitutes |
Ratner: pp. 26-32, Sections 2.12 and 7.7. |
| 22 |
Tissue Engineering
Cell Types
Approaches: In vitro, In vivo, Ex vivo/Cell Encapsulation
Scaffolds: Design and Fabrication |
Ratner: Chapter 8. |
| 23 |
Tissue Engineering (cont.)
Case Examples: Artificial Pancreas, Cartilage, Nerve Regeneration |
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| 24 |
FDA Regulatory Issues and Course Evaluations |
Ratner: Sections 10.1-10.4. |
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Final Exam |
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