| I. Principles Of Implant Design (Working Paradigms) |
| 1 |
Clinical Problems Requiring Implants for Solution |
I. V. Yannas / M. Spector |
Overview Slides (PDF - 1.2 MB)
Four Design Principles for Medical Devices (PDF)
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| 2 |
Principles of Implant Design / Design Parameters: Permanent versus Absorbable Devices |
I. V. Yannas / M. Spector |
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| 3 |
The Missing Organ and its Replacement |
I. V. Yannas |
The Problem of the Missing Organ (PDF) |
| 4 |
Criteria for Materials Selection |
I. V. Yannas |
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| 5 |
Tissue Engineering I: Scaffolds |
M. Spector |
Tissue Engineering I: Overview (PDF - 1.4 MB)
Tissue Engineering II: Scaffolds (PDF - 1.4 MB)
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| 6 |
Tissue Engineering II: Cells and Regulators |
M. Spector |
Tissue Engineering III: Growth Factors and Genes (PDF - 1.3 MB)
Tissue Engineering IV: Stem Cells (PDF - 1.2 MB)
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| 7 |
Case Study of Organ Regeneration |
I. V. Yannas |
Design Case Study: Device for Partial Regeneration of Skin (PDF) |
| II. Design Parameters |
| 8 |
Design Specifications: Biomaterials Survey |
M. Spector |
Biomaterials Survey (PDF)
Implant Fixation, Mechanical Stability and Modulus Matching (PDF - 1.2 MB)
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Quiz |
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| 9 |
Biocompatibility: Local and Systemic Effects |
M. Spector |
Biocompatibility (PDF - 1.3 MB) |
| 10 |
Design Specifications: Tissue Bonding and Modulus Matching |
M. Spector |
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| 11 |
Degradation of Devices: Natural and Synthetic Polymers |
I. V. Yannas |
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| 12 |
Biocompatibility: Scar Formation and Contraction |
I. V. Yannas |
Scar Formation Around Implants (PDF) |
| 13 |
Degradation of Devices: Corrosion and Wear |
M. Spector |
Degradation of Devices: Corrosion and Wear (PDF) |
| 14 |
Federal Regulation of Devices I |
M. Spector |
Federal Regulation of Medical Devices (PDF - 1.2 MB)
Recommended Biocompatibility Testing and Regulation of Tissue Engineered Products (PDF - 1.0 MB)
Summary of Federal Regulatory Issues and Clinical Trials (PDF - 1.1 MB)
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| 15 |
Oral Presentations of Proposals for Design II |
I. V. Yannas / M. Spector |
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| 16 |
Federal Regulation of Devices II |
M. Spector |
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| III. Design Solution In-use |
| 17 |
Scaffolds for Cartilage Repair |
S. Vickers |
Statistics: Type I and Type II errors (PDF) |
| 18 |
Implants for Bone |
M. Spector |
Bone Substitute Materials and Tissue Engineering (PDF - 1.4 MB) |
| 19 |
Implants for Plastic Surgery |
Dr. D. P. Orgill |
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| 20 |
Cardiovascular Prostheses: Heart Valves and Blood Vessels |
Dr. F. Schoe |
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| 21 |
Devices for Nerve Regeneration |
I. V. Yannas |
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| 22 |
Musculoskeletal Soft Tissues: Meniscus, Intervertebral Disk |
M. Spector |
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| 23 |
Dental and Otologic Implants |
M. Spector |
Dental Tissue Engineering (PDF) |
| 24 |
Other Devices: Spinal Cord, Heart Lung |
M. Spector |
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| 25 |
Final Oral Presentation of Designs (Mock FDA Panel) |
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