Lectures: 1 | 2 | 3 | 4-5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 15 | 16 | 17 | 19 | 20 | 21 | 22 | 23 | 26

Probability of Fixation and Sequence Comparison

1. Probability of Fixation
   • Population of N diploids, Selection s and Mutation Rate m.
2. Biological Implications of the Steady State Solution and Probability of Fixation
   • Heterozygosity of Human Population
   • Fixation of Neutral, Deleterious and Advantageous Mutations
3. Sequence Comparison
   • Protein Sequences (JPG): Amino Acids and their Properties
   • Why do we need to compare sequences?
     • Find Dissimilarities
     • Similar Sequences = Similar Properties
     • Similar Sequences = Common Ancestral Gene
   • Mutations -> Gapless Alignments
   • Mutations, Insertions and Deletions -> Gapped Alignment
4. Sequence Alignments
   • Score = edit distance
   • Examples of Scores
   • Length of Alignment, Number of Alignments
5. Algorithms for Sequence Alignments
   • Dynamics Programming
   • Example
   • Global and Local Alignments
6. Substitution Matrices
   • PAM
7. BLAST
   • How it Works
   • Examples