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7.012 Introduction to Biology, Fall 2004
7.013 Introductory Biology, Spring 2006
7.014 Introductory Biology, Spring 2005

7.012 Introduction to Biology, Fall 2004

These files are also available on iTunes® and YouTube™.

7.012 Video Files
LEC	AP TOPICS COVERED	DOWNLOADABLE MEDIA
1	History of Earth Organelles of the Eukaryotic Cell Organelles of Various Cell Types Prokaryotic and Eukaryotic Cells	(MP4 ‑ 82.9MB) (ZIP - 57.9MB) Transcript (PDF)
2	Atoms, Bonds, and Molecules in Biology Carbohydrates - Overview Hydrophobic, Hydrophilic, and Amphipathic Molecules Interactions Between Biological Molecules Phospholipid Bilayer Polymerization of Macromolecules	(MP4 ‑ 109.7MB) (ZIP - 76.7MB) Transcript (PDF)
3	Polymerization of Macromolecules Amino Acids and Proteins/Polypeptides Amino Acid Side Chains and Disulfide Bonds Three-Dimensional Structure of Proteins I Enzymatic and Structural Functions of Proteins Three-Dimensional Structure of Proteins II Biological Conditions and Enzyme Activity Nucleic Acids -- Overview	(MP3 ‑ 11.7MB) (ZIP - 5.9MB) Transcript (PDF)
4	Double Helix and Base Complementarity Nucleic Acids - Bases and Nomenclature Nucleic Acids - Polymerization Nucleic Acids - Structure Post-translational Modification RNA Double Helix Transmembrane Proteins	(MP4 ‑ 114.1MB) (ZIP - 80MB) Transcript (PDF)
5	Biochemical Reactions, Energy, and Enzymes Energy Production of Anaerobic and Aerobic Respiration Glycolysis and Krebs Cycle Mitochondria Function and Production of ATP	(MP4 ‑ 118MB) (ZIP - 82.3MB) Transcript (PDF)
6	Chromosomal Theory of Inheritance I Definitions in Genetics Mendel Mendel's Experiments and Law of Segregation Test Crosses as Proofs for Mendel's Model	(MP4 ‑ 116.6MB) (ZIP - 81.3MB) Transcript (PDF)
7	Chromosomal Theory of Inheritance II Genetic Distance and Recombination Genetic Linkage Genetic Maps Mendel's Law of Independent Assortment Sex Linkage	(MP4 ‑ 117.5MB) (ZIP - 81.7MB) Transcript (PDF)
9	Consanguinity and Recessive Inheritance Human Genetics and Pedigrees Other Influences of Inheritance Properties of X-linked and Autosomal Dominant Inheritance	(MP4 ‑ 115.5MB) (ZIP - 79.6MB) Transcript (PDF)
10	Genetic Material - Avery's Experiment Structure of DNA The Double Helix - Watson and Crick Transforming Principle - Griffith's Experiment	(MP4 ‑ 118.9MB) (ZIP - 81.9MB) Transcript (PDF)
11	DNA Replication - Components and Direction DNA Replication - Fidelity DNA Replication - Leading and Lagging Strands and Enzymes Transcription Translation I	(MP4 ‑ 105.7MB) (ZIP - 79.4MB) Transcript (PDF)
12	Alternative Splicing Post-Transcriptional Modifications Replication and Transcription in Viruses Translation II Variation on DNA Replication	(MP4 ‑ 118.7MB) (ZIP - 81.9MB) Transcript (PDF)
13	Gene Regulation in Bacteria Gene Regulation - Levels Structure of the Lac Operon and Transcriptional Repressor Transcriptional Activator	(MP4 ‑ 118.4MB) (ZIP - 82.3MB) Transcript (PDF)
15	Cloning - DNA Ligases Cloning Genes - Overview Cloning - Restriction Enzymes Cloning - Transformation and Selection Cloning - Vectors/Plasmids	(MP4 ‑ 116.4MB) (ZIP - 79.9MB) Transcript (PDF)
16	Cloning by Complementation Cloning by Position I Cloning by Sequence	(MP4 ‑ 115.9MB) (ZIP - 80.5MB) Transcript (PDF)
17	Cloning by Position II Expression Library Restriction Mapping and Gel Electrophoresis	(MP4 ‑ 116MB) (ZIP - 80.3MB) Transcript (PDF)
18	Polymerase Chain Reaction (PCR) PCR - Application Sequencing Genome	(MP4 ‑ 115.7MB) (ZIP - 80.3MB) Transcript (PDF)
19	Cell Cycle - Overview Cell Cycle - Regulation I Cell Growth and Division	(MP4 ‑ 112.6MB) (ZIP - 77.4MB) Transcript (PDF)
20	Cancer and Mutations Cancer Cells, Mutagens, and Carcinogens Cell Cycle - Regulation II	(MP4 ‑ 113.5MB) (ZIP - 78.6MB) Transcript (PDF)
21	Mutagens and Carcinogens	(MP4 ‑ 115.8MB) (ZIP - 80.3MB) Transcript (PDF)
22	Antibody Production Antibody/Immunoglobulin Structure Immune Response - Mechanism Immune Response - Primary and Secondary Viral Infections and Vaccines	(MP4 ‑ 108.1MB) (ZIP - 75.5MB) Transcript (PDF)
23	Antibody Variability and VDJ Recombination Humoral and Cellular Immunity Immunology - Definitions and Clonal Expansion Implications of Antibody Variability Macrophage and T Helper Cells I	(MP4 ‑ 115.2MB) (ZIP - 80.2MB) Transcript (PDF)
24	AIDS and HIV Macrophage and T Helper Cells II T Cell-B Cell Interaction	(MP4 ‑ 114.8MB) (ZIP - 79.8MB) Transcript (PDF)
25	Evolutionary Genomic Analysis	(MP4 ‑ 112.6MB) (ZIP - 78.3MB) Transcript (PDF)
26	Action Potential Mechanism Neurobiology - Concentration Gradients and Membrane Proteins Neurobiology - Electrical Signals Neurobiology - Introduction Neuron Structure Propagating Action Potential	(MP4 ‑ 113.3MB) (ZIP - 78MB) Transcript (PDF)
27	Nerve-Nerve Synapse Neural Circuitry Post-Synaptic Cell/ Muscle-Nerve Synapse Synaptic Transmission	(MP4 ‑ 113.6MB) (ZIP - 78.3MB) Transcript (PDF)
29	Growth and Differentiation Stem Cells - Hematopoiesis Stem Cells - Self Renewal	(MP4 ‑ 116.7MB) (ZIP - 80.5MB) Transcript (PDF)
32	Cohen Y Chromosome Darwinian Model Genetic Evidence for Evolution and Evolutionary Trees Genetics of Small Populations Human Migration and the Out-of-Africa Theory Mitochondrial DNA and Y Chromosome Polymorphisms	(MP4 ‑ 111.2MB) (ZIP - 77.5MB) Transcript (PDF)

7.013 Introductory Biology, Spring 2006

7.013 Video Files
LEC	AP TOPICS COVERED	DOWNLOADABLE MEDIA
19	Complexity in Development Development - Overview Examples of Processes in Development Genes Control Development I Genes Control Development II Multiple Steps to Final Fate Processes in Development Regeneration and Stem Cells Regulatory Factors During Development Teratogens Zebrafish Embryonic Development	(MP4 ‑ 106.6MB) (ZIP - 74.7MB) Transcript (PDF)
23	Definitions in Development Embryonic Stem (ES) Cells Stem Cells - Definition and Self Renewal Stem Cells - Discovery and Examples Stem Cells - Regulation by Gene Expression Stem Cells - Repopulation/Transplant Assays Stem Cells - Sample Lineages Stem Cells - Tissue Repair	(MP4 ‑ 108.7MB) (ZIP - 75.8MB) Transcript (PDF)

7.013 Audio Files (from Spring 2005)

7.013 Audio Files (from Spring 2005)
LEC	AP TOPICS COVERED	DOWNLOADABLE MEDIA
3	Introduction to Polymers and Bonds Lipids Carbohydrates Nucleic Acids	(MP3 ‑ 11.3MB) (ZIP - 4.9MB) Transcript (PDF)
5	Introduction to Enzymes Reaction Energetics and Enzymes Enzyme Function and Specificity Regulation of Enzyme Function Enzyme -- Activators and Inhibitors	(MP3 ‑ 11.3MB) (ZIP - 6MB) Transcript (PDF)
7	Genes and Chromosomes Stages of Meiosis Meiotic Recombination Errors in Meiosis Introduction to Mendelian Genetics	(MP3 ‑ 11.6MB) (ZIP - 5.9MB) Transcript (PDF)
8	Definitions in Genetics Mendel's First Law Mendel's Second Law Genetic Linkages	(MP3 ‑ 10.9MB) (ZIP - 3.8MB) Transcript (PDF)
9	Dominance Course Org Patterns of Inheritance Examples of Inheritance Framework for Studying Inheritance Penetrance	(MP3 ‑ 12.1MB) (ZIP - 5.9MB) Transcript (PDF)
11	Central Dogma DNA Repair The RNA Molecule Gene and RNA Classes Transcription Problems in Transcription	(MP3 ‑ 11.2MB) (ZIP - 5.7MB) Transcript (PDF)
12	Silence Promoters, Introns, Exons, and Splicing Gene Expression -- Translation Ribosomes mRNA and Initiation of Translation Elongation and Termination of Translation Mutations -- Genotype to Phenotype	(MP3 ‑ 11.3MB) (ZIP - 6MB) Transcript (PDF)
13	"How to" Guide to Genetic Engineering Restriction Enzymes Gel Electrophoreisis DNA Transformation	(MP3 ‑ 11.4MB) (ZIP - 5.7MB) Transcript (PDF)
14	Silence Review DNA Transformation Polymerase Chain Reaction cDNA cloning	(MP3 ‑ 11.3MB) (ZIP - 4.9MB) Transcript (PDF)
19	The Cell Cycle History of the Exploration of the Cell Cycle Checkpoints Cell Death	(MP3 ‑ 10.1MB) (ZIP - 5.9MB) Transcript (PDF)
20	Final Formation of Skeletal Muscle Cells Sexual Reproduction and Fertilization Gametogenesis Male Reproductive System Female Reproductive System Hormonal Control of Gametogenesis Process of Fertilization	(MP3 ‑ 10.7MB) (ZIP - 5.9MB) Transcript (PDF)
21	Review of Video Lecture 19 Differentiation of Skeletal Muscle Cells Gene Family Gene Expression Fate Mapping Determination Assay Dorsal Determination Germ Layers and the Dorsal Mesoderm Experiments with Network of Regulators	(MP3 ‑ 11.2MB) (ZIP - 5.7MB) Transcript (PDF)
22	Three Dimensional Structures and Function Cells as the Building Block Adhesion and Junctions Extracellular Matrix Cytoskeleton 3D structure	(MP3 ‑ 11.2MB) (ZIP - 4.9MB) Transcript (PDF)

7.014 Introductory Biology, Spring 2005

These files are also available on iTunes® and YouTube™.

7.014 Video Files
LEC	AP TOPICS COVERED	DOWNLOADABLE MEDIA
1	Levels of Biological Studies Levels of Multicellular Organisms Origin of Life Prokaryotic and Eukaryotic Cells	(MP4 ‑ 104.8MB) (ZIP - 72.9MB) Transcript (PDF)
2	Carbohydrates - Overview Cell Composition Chirality Covalent Bond Hydrogen Bond	(MP4 ‑ 109.5MB) (ZIP - 76.5MB) Transcript (PDF)
3	Hydrophobic Effects Ionic Bond and van der Waals (VDW) Interaction Nucleic Acids - DNA and RNA IntrodProtein Primary and Secondary Structures Iuction Proteins and Amino Acids	(MP4 ‑ 95MB) (ZIP - 76.4MB) Transcript (PDF)
4	Autotrophs and Heterotrophs Cell Characteristics Lipids and Phospholipid Bilayer Protein Functions Protein Primary and Secondary Structure II Protein Quaternary Structure Protein Tertiary Structure	(MP4 ‑ 109.8MB) (ZIP - 76.6MB) Transcript (PDF)
5	Activation Energy and Enzymes Coupled Reactions Fermentation Reactions - Thermodynamics and Gibbs Free Energy	(MP4 ‑ 104.9MB) (ZIP - 86.4MB) Transcript (PDF)
6	ATP Glycolysis Pyruvate Conversion Redox Reaction	(MP4 ‑ 96.4MB) (ZIP - 77.5MB) Transcript (PDF)
7	Citric Acid Cycle and the Mitochondrion Fatty Acid Synthesis from Glycolytic Intermediates Forms of Energy and Proton Gradient Glycolysis and Pyruvate Conversion Oxidative Phosphorylation Regulation of Glycolysis Respiration	(MP4 ‑ 104.7MB) (ZIP - 84.5MB) Transcript (PDF)
8	DNA - Overview Genes Genetic Material - Avery's Experiment Genetic Material - Griffith's Experiment Photosynthesis Release I Photosynthesis Release II	(MP4 ‑ 108.3MB) (ZIP - 89.6MB) Transcript (PDF)
9	DNA Content - Chargaff's Experiment DNA Structure - Watson and Crick I DNA Structure - Watson and Crick II Meselson-Stahl Experiment	(MP4 ‑ 96.2MB) (ZIP - 78.8MB) Transcript (PDF)
10	DNA Replication - DNA Polymerase DNA Replication - Replication Fork	(MP4 ‑ 105.4MB) (ZIP - 75.7MB) Transcript (PDF)
11	Cancer DNA Repair DNA Replication - Fidelity DNA Replication - Initiation Information Storage in DNA	(MP4 ‑ 105MB) (ZIP - 73.2MB) Transcript (PDF)
12	DNA to Protein Genetic Code Messenger RNA (mRNA) Protein Synthesis Transcriptional Regulation Transfer RNA (tRNA) and Codons	(MP4 ‑ 115.3MB) (ZIP - 92.3MB) Transcript (PDF)
13	Cell Regulatory Decisions Lactose Metabolism Ribozyme RNA Splicing RNA Splicing - Examples RNA Viruses and HIV The Central Dogma	(MP4 ‑ 116MB) (ZIP - 81.2MB) Transcript (PDF)
14	Gene Regulation - Positive and Negative Gene Regulation - Positive Regulation Lactose Operon and Regulatory Components II Promotors	(MP4 ‑ 108.5MB) (ZIP - 86.8MB) Transcript (PDF)
15	Bacteriophage Genetics and Biochemical Pathways Genetics - Definitions Mutant Analysis - Complementation Test Mutant Analysis - Recombination Test	(MP4 ‑ 107.6MB) (ZIP - 74.4MB) Transcript (PDF)
16	Biogeochemistry Emergent Properties Molecular Ecology Organism/Environment Interaction Overview of Ecology	(MP4 ‑ 103.2MB) (ZIP - 83.3MB) Transcript (PDF)
17	Autotrophs and the Calvin Cycle Carbon and Energy Sources - Introduction Chemosynthesis Heterotrophs and Aerobic and Anaerobic Respiration Oxygenic and Anoxygenic Photosynthesis System for Bacteria	(MP4 ‑ 87.5MB) (ZIP - 70.2MB) Transcript (PDF)
18	Comparison of Ecosystems Food Web and Energy Transfers Primary Productivity World Net Productivity	(MP4 ‑ 95.3MB) (ZIP - 76.4MB) Transcript (PDF)
19	Biosynthesis and Regeneration Importance of Nutrients Lake Ecosystems and Mixing Ocean Nutrient Renewal Terrestrial Ecosystems Water Column	(MP4 ‑ 106.3MB) (ZIP - 86.3MB) Transcript (PDF)
20	Biogeochemical Cycles - Overview Geological Cycle Global Carbon Cycle Global Nitrogen Cycle Global Phosphorous Cycle Water Cycle	(MP4 ‑ 106.2MB) (ZIP - 74.5MB) Transcript (PDF)
21	Mendel's Experiments Mendel's Law of Segregation	(MP4 ‑ 105.4MB) (ZIP - 80.1MB) Transcript (PDF)
22	Cell Cycle and Regulation Chromosomal Theory of Inheritance I Chromosome and Mitosis Meiosis - Overview Non-Disjunction	(MP4 ‑ 108.4MB) (ZIP - 76MB) Transcript (PDF)
23	Chromosomal Theory of Inheritance II Genetic Recombination and Genetic Maps Human Genetics and Pedigrees Mendel's Law of Independent Assortment Sex Linkage	(MP4 ‑ 117MB) (ZIP - 82.5MB) Transcript (PDF)
24	Cloning by Complementation Cloning Genes - Overview Cloning Genes - Steps Discovery of Restriction Enzymes Recombinant DNA - Libraries I Restriction Enzymes I	(MP4 ‑ 92.4MB) (ZIP - 65.6MB) Transcript (PDF)
25	DNA Sequencing I Gel Electrophoresis and Restriction Maps Polymerase Chain Reaction (PCR)	(MP4 ‑ 72.8MB) (ZIP - 51MB) Transcript (PDF)
26	Cloning by Hybridization/Sequence Cloning by Position Recombinant DNA for Eukaryotes I Recombinant DNA - Libraries II Restriction Enzymes II Vectors/Plasmids	(MP4 ‑ 92.5MB) (ZIP - 65.7MB) Transcript (PDF)
27	Adaptive Immune System DNA Sequencing II Recombinant DNA for Eukaryotes II	(MP4 ‑ 115.9MB) (ZIP - 80.3MB) Transcript (PDF)
28	Antibodies and VDJ Recombination Clonal Selection, Plasma and Memory Cells Humoral Versus Cellular Immunity Pathogen Elimination T Cells Tolerance of Self Peptides	(MP4 ‑ 107.9MB) (ZIP - 86.6MB) Transcript (PDF)
29	Age Structure Cohort Life Tables - Definitions and Analysis Exponential Population Growth and Stable Age Distribution Measure Abundance Population Ecology - Introduction	(MP4 ‑ 95.9MB) (ZIP - 68.1MB) Transcript (PDF)
30	Carrying Capacity of the Earth Demographic Transition Global Population Study Human Population Growth I Logistic Versus Exponential Equation Time Lag US Population Study	(MP4 ‑ 104.4MB) (ZIP - 83.8MB) Transcript (PDF)
31	Endosymbiosis Theory Life on Earth Molecular Ecology Molecular Evolution Universal Phylogenetic Trees	(MP4 ‑ 112.3MB) (ZIP - 93.6MB) Transcript (PDF)
32	Environmental Genomes Genomics In Situ Identification of Micro-organisms Insights Gained from Genomics	(MP4 ‑ 117.5MB) (ZIP - 81.8MB) Transcript (PDF)
33	Character Displacement Community Ecology Competition Competition Experiment Ecological Niche Invasive Species and Competitive Exclusion Species Interactions	(MP4 ‑ 100.6MB) (ZIP - 81.1MB) Transcript (PDF)
34	Evolution - Interspecific Competition Predation Predation and Community Structure	(MP4 ‑ 106.9MB) (ZIP - 51.1MB) Transcript (PDF)
35	Mutualism Predation and Evolution	(MP3 ‑ 3.8MB) (ZIP) Transcript (PDF)