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Video Clips

RealVideo®
4:14 minutes (6:26 - 10:40)
Independent assortment of traits and chromosomes demonstrated by dihybrid crosses with two traits.
Prof. Eric Lander, Prof. Robert Weinberg, Dr. Claudette Gardel
Mendel's Law of Segregation and Chromosomes
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RealVideo®
14:14 minutes (14:53 - 29:07)
Morgan's experiments with fruit flies showed linkage between two genes/traits. Dihybrid crosses with two traits show genetic recombination and genetic distances.
Prof. Eric Lander, Prof. Robert Weinberg, Dr. Claudette Gardel
Mendel's Law of Segregation and Chromosomes
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RealVideo®
13:39 minutes (29:07 - 42:46)
Sturtevant's work with multiple traits mapped out genes on chromosomes based on recombination frequencies. Genetic maps allowed biologists to predict frequency of double recombination.
Prof. Eric Lander, Prof. Robert Weinberg, Dr. Claudette Gardel
Genetic linkage, distance, and recombination
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RealVideo®
8:29 minutes (42:46 - 51:15)
X and Y chromosomes determine gender. In fruit flies, certain physical traits such as eye color lie on the X chromosome and are linked to the sex of the fly.
Prof. Eric Lander, Prof. Robert Weinberg, Dr. Claudette Gardel
Genetic linkage, distance, and recombination
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RealVideo®
12:26 minutes (8:57 - 21:23)
Eukaryotes and prokaryotes vary in DNA replication due to differences in chromosome structure and genome sizes.
Prof. Eric Lander, Prof. Robert Weinberg, Dr. Claudette Gardel
DNA replication
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RealVideo®
7:35 minutes (41:50 - 49:25)
The discovery of chromosomes and brief overview of meiosis in the context of Mendel's work. Chromosome theory of inheritance-traits are carried on chromosomes that segregate when gametes form.
Prof. Eric Lander, Prof. Robert Weinberg, Dr. Claudette Gardel
Mendel's experiments
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RealVideo®
4:21 minutes (2:05 - 6:26)
Brief overview of mitosis and meiosis and the segregation of chromosomes in the context of Mendel's theory.
Prof. Eric Lander, Prof. Robert Weinberg, Dr. Claudette Gardel
Follows from previous lecture
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RealVideo®
9:05 minutes (7:43 - 16:48)
Characteristics of chromosomes. Drawing of mitosis and the changes and segregation of chromosomes. Definition: Mitosis, chromosome, chromatid, and centrosome. Great video of mitosis.
Prof. Penny Chisholm, Prof. Graham Walker, Dr. Julia Khodor, Dr. Michelle Mischke
None
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RealVideo®
8:32 minutes (36:48 - 45:20)
Autosomes versus sex chromosomes. Morgan's experiment which discovered sex-linkage. Carriers and inheritance patterns.
Prof. Penny Chisholm, Prof. Graham Walker, Dr. Julia Khodor, Dr. Michelle Mischke
Meiosis and genetic linkage
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Audio Clip

RealVideo®
4:34 minutes (0:40 - 5:14)
Details about genes, chromosomes, and the human genome.
Prof. Tyler Jacks, Prof. Hazel Sive
None
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Lecture Notes

PDF
Big Idea 2
Clarification of genes, alleles, traits, genotype, phenotype, and dominance.
Prof. Eric Lander, Prof. Robert Weinberg, Dr. Claudette Gardel
None
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Practice Problems

PDF
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Problem 2 (page 2)
Recombination between two linked genes used to construct genetic maps.
Prof. Eric Lander, Prof. Robert Weinberg, Dr. Claudette Gardel
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PDF
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Problem 3 (page 4)
Comparison between chromosomal segregation during mitosis, meiosis I and meiosis II and DNA recombination.
Prof. Eric Lander, Prof. Robert Weinberg, Dr. Claudette Gardel
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PDF
Problem 1 (page 1)
Use family pedigree to predict the mode of inheritance. Predict gene arrangement on the chromosomes based on linkage.
Prof. Tyler Jacks, Prof. Hazel Sive
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PDF
Problem 2 (page 2)
Characteristics of linked genes and calculation of recombination frequencies.
Prof. Penny Chisholm, Prof. Graham Walker, Dr. Julia Khodor, Dr. Michelle Mischke
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PDF
All problems (All pages)
Table comparing cell division through mitosis and meiosis-process and cellular components involved.
Prof. Tyler Jacks, Prof. Hazel Sive
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PDF
Problem A (page 1)
Conceptual questions on the Chromosomal Theory of Inheritance, sexual reproduction, and chromosomal recombination.
Prof. Penny Chisholm, Prof. Graham Walker, Dr. Julia Khodor, Dr. Michelle Mischke
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PDF
Problem B (page 1)
Two examples of human pedigrees used to predict the mode of inheritance. Recombination is taken into consideration when calculating probability of inheritance.
Prof. Penny Chisholm, Prof. Graham Walker, Dr. Julia Khodor, Dr. Michelle Mischke
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