Course Meeting Times

Lectures: 2 sessions / week; 1.5 hours / session

Recitations: 1 session / week; 1 hour / session


Permission of the instructor.


This course addresses the scientific basis for the development of new drugs. The first half of the semester begins with an overview of the drug discovery process, followed by fundamental principles of pharmacokinetics, pharmacodynamics, metabolism, and the mechanisms by which drugs cause therapeutic and toxic responses. The second half of the semester applies those principles to case studies and literature discussions of current problems with specific drugs, drug classes, and therapeutic targets.



Buy at Amazon Golan, David E., Armen H. Tashjian, and Ehrin J. Armstrong, eds. Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. Lippincott Williams & Wilkins, 2011. ISBN: 9781608312702. [Preview with Google Books]

Buy at Amazon Klaassen, Curtis. Casarett & Doull's Toxicology: The Basic Science of Poisons. 8th ed. McGraw-Hill Professional, 2013. ISBN: 9780071769235.

Other Recommended Texts

Buy at Amazon Gilman, A. G., T. W. Rall, et al. Goodman and Gilman's The Pharmacological Basis of Therapeutics. McGraw-Hill Professional, 1996. ISBN: 9780070262669.

Physiology Texts

Buy at Amazon Guyton, Arthur C., and John E. Hall. Textbook of Medical Physiology. 10th ed. Saunders, 2000. ISBN: 9780721686776. [Preview with Google Books]

Buy at Amazon Widmaier, Eric, Hershel Raff, and Kevin Strang. Human Physiology: The Mechanisms of Body Function. 7 Sub ed. William C Brown Pubulication, 1998. ISBN: 9780070670655.

Histology Texts

Buy at Amazon Mescher, Anthony. Junqueira's Basic Histology: Text and Atlas. 13th ed. McGraw-Hill Medical, 2013. ISBN: 9780071780339. [Preview with Google Books]

Buy at Amazon Bloom, William, and Don W. Fawcett. A Textbook of Histology. 10th ed. W. B. Saunders, 1975. ISBN: 9780721617572.


Exam 30
Homework 20
Case Study Project 30
Reading & Discussion of Assigned Papers 20