Biomaterials-Tissue Interactions

Drawing of hip implant, highlighting porous surfaces for tissue ingrowth.

This implant for a total hip replacement is designed with various porous surfaces that encourage tissue ingrowth. (Figure by MIT OpenCourseWare.)


MIT Course Number

20.441J / 2.79J / 3.96J / HST.522J

As Taught In

Fall 2009



Cite This Course

Course Features

Course Description

This course covers the principles of materials science and cell biology underlying the design of medical implants, artificial organs, and matrices for tissue engineering. Methods for biomaterials surface characterization and analysis of protein adsorption on biomaterials. Molecular and cellular interactions with biomaterials are analyzed in terms of unit cell processes, such as matrix synthesis, degradation, and contraction. Mechanisms underlying wound healing and tissue remodeling following implantation in various organs. Tissue and organ regeneration. Design of implants and prostheses based on control of biomaterials-tissue interactions. Comparative analysis of intact, biodegradable, and bioreplaceable implants by reference to case studies. Criteria for restoration of physiological function for tissues and organs.

Archived Versions

Yannas, Ioannis, and Myron Spector. 20.441J Biomaterials-Tissue Interactions, Fall 2009. (MIT OpenCourseWare: Massachusetts Institute of Technology), (Accessed). License: Creative Commons BY-NC-SA

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