Molecular Principles of Biomaterials

Lecture Notes

LEC #	TOPICS	SLIDES	ANNOTATED
1	Overview of Course, Orientation to Current Approaches and Types of Molecularly-designed Biomaterials Biodegradable Polymeric Solids Chemistry and Physical Chemistry of Hydrolysis Links between Materials Structure and Hydrolysis Mechanisms	(PDF - 1.6 MB)	(PDF - 1.7 MB)
2	Biodegradable Polymeric Solids (cont.) Factors Controlling Polymer Degradation Rates Theory of Solid Polymer Erosion Tailoring Degradable Polymer Structure and Composition	(PDF)	(PDF)
3	Controlled Release Devices Types of Controlled Release Devices Degradable Materials in Controlled Release Devices Physical Chemistry Principles in Delivering Small Molecules vs. Proteins	(PDF)	(PDF)
4	Controlled Release Devices (cont.) Theory of Drug Release in Eroding Systems	(PDF)	(PDF - 1.1 MB)
5	Case Studies in Complex Controlled Release Pulsatile Release from Programmed Eroding Systems Controlled Release Microchips Combining Drug Delivery with Tissue Engineering
6	Hydrogels as Biomaterials Hydrogel Structure and Physical Chemistry Methods of Polymerization	(PDF - 2.0 MB)
7	Hydrogels as Biomaterials (cont.) Theory of Hydrogel Swelling Physical Hydrogels Ionic and Hydrogen Bonding in Gels Association of Amphiphilic Block Copolymers	(PDF)	(PDF)
8	Hydrogels as Biomaterials (cont.) Polyelectrolyte Hydrogels Coacervates Polyelectrolyte Multi-layers	(PDF)	(PDF)
9	Hydrogels as Biomaterials (cont.) Theory of Polyelectrolyte Gel Swelling	(PDF - 1.1 MB)	(PDF - 1.2 MB)
10	Hydrogels as Biomaterials (cont.) Applications of Hydrogels: Molecular Imprinting Applications of Hydrogels: Glucose-sensitive Drug Delivery Kinetics of Drug Diffusion through Hydrogels	(PDF - 1.1 MB)	(PDF - 1.2 MB)
11	Engineering Biological Recognition of Biomaterials Biological Recognition in Vivo Protein-resistant and Cell-resistant Surfaces Engineering Recognition of Biomaterials: Adhesion and Migration	(PDF - 2.3 MB)	(PDF - 1.8 MB)
12	Engineering Biological Recognition of Biomaterials (cont.) Enzymatic Recognition of Biomaterials Cytokine Signaling from Biomaterials	(PDF - 1.8 MB)	(PDF - 2.0 MB)
13	Engineering Biological Recognition of Biomaterials (cont.) Mimicking Cell-cell Contacts with Surfaces	(PDF - 2.9 MB)	(PDF - 3.4 MB)
14	Bioceramics and Biocomposites Introduction to Biological Approaches to Biomineralization Interfacial Biomineralization	(PDF - 1.6 MB)	(PDF - 2.2 MB)
15	Bioceramics and Biocomposites (cont.) Biological Control of Mineralization within Vesicles Biomimetic Syntheses: Microemulsion and Micellar Reactions Organic Templating of Inorganic Biomaterials: Natural and Synthetic Approaches	(PDF)	(PDF - 1.7 MB)
16	Bioceramics and Biocomposites (cont.) Theory of Controlled Nucleation Bone Structure and Bone Biomimesis Biocomposites in Device Applications and Drug Delivery	(PDF - 1.0 MB)	(PDF - 2.2 MB)
17	Molecular Devices Molecular Switches via Proteins and ‘Smart’ Polymers Temperature, pH, and Light-sensitive Switches Molecular Motors Kinesin-based Molecular Shuttles ATP Synthase-based Nano-rotors	(PDF - 1.4 MB)	(PDF - 1.5 MB)
18	Nanoparticle and Microparticle Biomolecule Drug Carriers Pro-drugs, Micelles, Liposomes, Polymerosomes, Nanoparticles, and Microparticles Delivery of Drugs to Tissues via Systemic Circulation Materials for Anti-Cancer Drug Delivery	(PDF - 4.1 MB)	(PDF - 4.6 MB)
19	Nanoparticle and Microparticle Biomolecule Drug Carriers (cont.) Barriers to Systemic / Oral Delivery and Delivery of Molecules to Tissues ‘Stealth’ Particles Theory of Protein-resistant Particles Experimental Function of Long-circulating Carriers and PEGylated Compounds	(PDF - 2.0 MB)	(PDF - 2.2 MB)
Focus Topic: Integrating Biological Knowledge Into Biomaterials Design For Vaccines
20	Basic Biology of Vaccination and Viral Infections Rudiments of Adaptive Immunity: The Basis of Vaccination Viral Infections	(PDF)	(PDF - 1.3 MB)
21	Basic Biology of Vaccination and Viral Infections (cont.) Vaccination Against Viruses: Parallels between Immunization and Infection	(PDF)	(PDF - 1.5 MB)
22	Drug Targeting and Intracellular Drug Delivery for Vaccines Targeting Nano-carriers and Micro-carriers to Specific Cell Types Chemistry of Antibodies for Targeting Pathways of Intracellular Transport	(PDF)	(PDF)
23	Drug Targeting and Intracellular Drug Delivery for Vaccines (cont.) Mechanisms of Intracellular Delivery Mimicking Viral Entry Strategies	(PDF - 2.8 MB)	(PDF - 3.1 MB)
24	DNA Vaccines Gene Therapy and DNA Immunization Mechanisms of DNA Vaccines	(PDF - 4.1 MB)	(PDF - 4.7 MB)
25	DNA Vaccines (cont.) Delivery Systems for DNA Systemic vs. Local Delivery