Lecture Notes

LEC # TOPICS LECTURERS LecTURE noTES
I. Unit Cell Processes and Mechanics of Matrix Molecules and Tissues Structures
1 Clinical Examples of the Roles of Mechanical Forces in Tissues and Organs: The Working Paradigms Prof. Spector (PDF)
2 Tissue Structures and Unit Cell Processes Prof. Spector (PDF 1)

(PDF 2)

(PDF 3)
3 Cell-Matrix Interactions: Extracellular Matrix Molecules, Adhesion Proteins and Integrins Prof. Spector (PDF 1)

(PDF 2)
4 Models for the Mechanical Behavior of Porous Scaffolds Prof. L. Gibson (PDF)
5 Structure-Properties Relationships for Tissues Prof. Spector  
6 Mechanics of Selected Tissues Prof. S. Socrate  
II. Mechanics of Cells: Effects of Exogenous Forces and Endogenous Force Generation
7 Effects of Exogenous Mechanical Forces on Cells Prof. Spector  
8 Response of Cells to Substrate Strain Prof. Spector (PDF)
9 Endothelial Cell Response to Flow Prof. C. F. Dewey  
10 Quiz 1    
11 Measuring Cell Contraction

Cell Force Monitor
Brendan Harley (PDF)
12 Endogenous Mechanical Force Generation by Cells Prof. Spector (PDF 1)

(PDF 2)
13 Models for Cell Contraction In Vitro and In Vivo Prof. Spector (PDF 1)

(PDF 2)
14 Mechanical Coupling of Cells with Matrix Prof. Yannas (PDF 1)

(PDF 2)
15 Cell-matrix Interactions During Wound Closure Prof. Yannas (PDF - 1.6 MB)
16 Blockade of Contraction During Induced Organ Regeneration Prof. Yannas (PDF - 1.6 MB)
17 Review Prof. Spector  
18 Quiz 2    
III. Tissue Mechanics
19 Review of Principles of Linear Elastic Mechanics Prof. Yannas (PDF - 1.1 MB)
20 Nonlinear Elasticity: Tendon and Skin Prof. Yannas (PDF)
21 Linear Viscoelastic Behavior Prof. Yannas (PDF - 1.0 MB)
22 Response of Articular Cartilage to Mechanical Loading Prof. A. Grodzinsky  
23 Mechanical Behavior of Ligament, Meniscus and Intervertebral Disc Prof. Spector (PDF 1)

(PDF 2)
24 Mechanical Behavior of Bone Prof. Spector (PDF)
25 Response of Bone to Mechanical Loading

Review
Prof. Spector (PDF)
26 Quiz 3