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Readings

HST.947 students are expected to complete all readings for 6.034. The Chapter readings assigned for lecture sessions (L) come from the course lecture notes. Additonal readings are assigned for the weekly discussion sessions (D) as listed in the table.

SES # TOPICS READINGS

D1

Organizational Meeting

L1

Introduction

Chapter 1

R1

Scheme Review and Matching

L2

Search

Chapter 3 (Sec 3.1-3.5)

D2

Introduction to Diagnostic Reasoning

Szolovits, P., and S. G. Pauker. "Categorical and probabilistic reasoning in medical diagnosis." Artificial Intelligence 11, nos. 1-2 (1978): 115-144.

Pauker, S. G., G. A. Gorry, J. P. Kassirer, and W. B. Schwartz. "Toward the Simulation of Clinical Cognition: Taking the Present Illness." American Journal of Medicine 60 (1976): 1-18.

L3

Search (cont.)

Chapter 4 (Sec 4.1-4.3)

R2

Searches

L4

Constraint Satisfaction

Chapter 5

D3

Diagnosis by Pattern Matching and Search

Wu, T. D. "Efficient Diagnosis of Multiple Disorders Based on a Symptom Clustering Approach." In Proceedings of the Eighth National Conference on Artificial Intelligence. Menlo Park, CA: AAAI Press, 1990, pp. 357-364.

Amazon logo Pople, H. E., Jr. "Heuristic Methods for Imposing Structure on Ill-Structured Problems: The Structuring of Medical Diagnostics." Chapter 5 in Artificial Intelligence in Medicine. Edited by P. Szolovits. Boulder, CO: Westview Press, 1982, pp. 119-190. ISBN: 9780891589006.

L5

Games

Chapter 6 (Sec 6.1-6.3)

R3

CSP and Games

L6

Learning as Search

D4

Causal Reasoning

Schwartz, W. B., R. S. Patil, and P. Szolovits. "Artificial intelligence in medicine: where do we stand." New England Journal of Medicine 316 (1987): 685-688.

Patil, R. S., P. Szolovits, and W. B. Schwartz. "Causal understanding of patient illness in medical diagnosis." In Proceedings of the Seventh International Joint Conference on Artificial Intelligence, 1981, pp. 893-899.

———. "Information acquisition in diagnosis." In Proceedings of the National Conference on Artificial Intelligence. American Association for Artificial Intelligence, 1982, pp. 345-348.

Patil, R. S. "Causal Representation of Patient Illness for Electrolyte and Acid-Base Diagnosis." MIT Ph.D. Thesis, 1981.

L7

Formulating Search

R4

Design Project 1

L8

Decision Trees

Chapter 18 (Sec 18.1-18.3)

D5

Receiver-Operator Characteristics Curves to Evaluate Systems

Lasko, T. A., J. G. Bhagwat, K. H. Zou, and L. Ohno-Machado. The Use of Receiver Operating Characteristic Curves in Biomedical Informatics. (In press.)

L9

Naïve Bayes

Chapter 18 (Sec 18.1-18.3)

R5

Design Project 1 Presentation and Question-Answer

Q1

Quiz 1

D6

Prognostic Modeling

Cooper, Gregory F., et al. "Predicting Dire Outcomes of Patients with Community Acquired Pneumonia." Journal of Biomedical Informatics 38, no. 5 (2005): 347-366.

L10

Continuous Features

Chapter 20 (Sec 20.4)

R6

Naïve Bayes and Nearest Neighbor

L11

Linear Separators

Chapter 20 (Sec 20.5-20.6)

D7

Classification Methods for Gene Expression Data

Statnikov, A., et al. "A comprehensive evaluation of multicategory classification methods for microarray gene expression cancer diagnosis." Bioinformatics 21, no. 5 (2005): 631-643.

Kuo, W. P., et al. "A primer on gene expression and microarrays for machine learning researchers." Journal of Biomedical Informatics 37 (2004): 293–303.

L12

Neural Nets

Chapter 20 (Sec 20.5-20.6)

R7

SVM

L13

SVM

Chapter 20 (Sec 20.5-20.6)

D8

Predictive Models

Marcin, J. P., et al. "Combining physician's subjective and physiology-based objective mortality risk predictions." Crit Care Med 28, no. 8 (2000): 2984-90.

Steyerberg, E. W., et al. "Validation and updating of predictive logistic regression models: a study on sample size and shrinkage." Statist Med 23 (2004): 2567-2586.

L14

Feature and Model Selection

Chapter 20 (Sec 20.5-20.6)

R8

Problem Set 6

Q2

Quiz 2

D9

Learning Medical Reasoning

Coderre, S., et al. "Diagnostic reasoning strategies and diagnostic success." Medical Education 37 (2003): 695-703.

Arocha, J. F., et al. "Identifying reasoning strategies in medical decision making: A methodological guide." Journal of Biomedical Informatics (2005 - in press.)

L15

Formulating Learning

R9

Introduction to Logic

L16

Introduction to Logic and Representation

D10

Pragmatics

Hunt, D. L., et al. "Effects of Computer-Based Clinical Decision Support Systems on Physician Performance and Patient Outcomes." JAMA 280, no. 15 (1998): 1339-46.

Kawamoto, K., et al. "Improving clinical practice using clinical decision support systems: a systematic review of trials to identify features critical to success." BMJ (British Medical Journal) 330, no. 7494 (2005): 765.

Ammenwerth, E., and N. de Keizer. "An Inventory of Evaluation Studies of Information Technology in Health Care." Methods Inf Med 44 (2005): 44-56.

Nielsen, J. "Medical Usability: How to Kill Patients Through Bad Design."

L17

Propositional Logic

Chapter 7 (Sec 7.1-7.5)

R10

Design Project 2 Presentation and Question-Answer

D11

Medical Knowledge Representation

Rector, A. L., et al. "The GRAIL Concept Modelling Language for Medical Terminology." Extended version of the paper in Artificial Intelligence in Medicine 9 (1997): 139-171.

Trombert-Paviot, B., et al. "GALEN: a third generation terminology tool to support a multipurpose national coding system for surgical procedures." International Journal of Medical Informatics 58-59 (2000): 71-85.

L18

Introduction to Natural Language Processing

R11

Logic and Proof

L19

First Order Logic

Chapter 8 (Sec 8.1-8.3)

D12

Evaluation of Complex Decision Support Systems

Berner, E. S., et al. "Performance of Four Computer-Based Diagnostic Systems." New England Journal of Medicine 300 (1994): 1792-6.

Fraser, H. S. F., et al. "Evaluation of a Cardiac Diagnostic Program in a Typical Clinical Setting." Journal of the American Medical Informatics Association 10 (2003): 373-381.

L20

First Order Logic (cont.)

Chapter 9 (Sec 9.1, 9.2, 9.5)

R12

Syntax and Semantics

L21

Rules

Chapter 9 (Sec 9.4)

D13

Rule-Based Expert Systems

Davis, R., B. G. Buchanan, and E. H. Shortliffe. "Production Rules as a Representation for a Knowledge-Based Consultation Program." Artificial Intelligence 8 (1977): 15-45.

Yu, V. L., B. G. Buchanan, E. H. Shortliffe, S. M. Wraith, R. Davis, A. C. Scott, and S. N. Cohen. "Evaluating the Performance of a Computer-Based Consultant." Comp Programs in Biomedicine 9 (1979): 95-102.

Yu, V. L., et al. "Antimicrobial Selection by a Computer: A Blinded Evaluation by Infectious Diseases Experts." JAMA 242, no. 12 (1979): 1279-82.

L22

Language

Chapter 22 (Sec 22.1-22.5)

R13

Problem Set 9

L23

Language

Chapter 22 (Sec 22.1-22.5)

D14

Student Presentations

L24

Conclusion

Final Exam