This course presents the main concepts of decision analysis, artificial intelligence, and predictive model construction and evaluation in the specific context of medical applications. The advantages and disadvantages of using these methods in real-world systems are emphasized, while students gain hands-on experience with application specific methods. The technical focus of the course includes decision analysis, knowledge-based systems (qualitative and quantitative), learning systems (including logistic regression, classification trees, neural networks), and techniques to evaluate the performance of such systems.