Lecture 19

Lectures: 1 | 2 | 3 | 4-5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 15 | 16 | 17 | 19 | 20 | 21 | 22 | 23 | 26

Microtubules

1. Filaments in the Cycloskeleton; Major Types:
   • Actin Filaments
   • Intermediate Filaments
   • Microtubules
2. Microtubule Structure:
   • Tubulin Subunits
   • Protofilaments, Nucleation and Growth
   • Polarity
3. Dynamic Instability:
   • Dogterom, Marileen, and Stanislas Leibler. "Physical Aspects of the Growth and Regulation of Microtubule Structures." Physics Review Letters 70, no. 9 (March 1, 1993): 1347.
   • Flyvbjerg, Henrik, Timothy E. Holy, and Stanislas Leibler. "Stochastic Dynamics of Microtubules: A Model for Caps and Catastrophes." Physics Review Letters 73, no. 17 (October 24, 1994): 2372.
   • Lecture Notes: Page 1 (GIF), Page 2 (GIF), Page 3 (GIF), Page 4 (GIF)
4. Search Strategy:
   • Mitosis
   • Condensation of RecA on ssDNA as a Tool for Computation by Stochastic Assembly
   • Kinetic Proof-reading
     • Fidelity of Replication (Hopfield 74)
     • Recognition by T Cells
5. Self-organization of Microtubules and Motors in Vitro

Some Related Links

• Microtubule Links
• Nonosimulations of the Cytoskeleton (a PhD Thesis by Christopher Betts)