Lecture 2

Lectures: 1 | 2 | 3 | 4-5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 15 | 16 | 17 | 19 | 20 | 21 | 22 | 23 | 26

Foundations of Molecular Evolution and Population Genetics

1. Review of the Central Dogma
   • Coding Sequences and Gene Expression
     • Gene (FASTA)
     • Protein (FASTA)
     • Genome (FASTA)
   • Genetic Code
2. Mutations, DNA Variation
   • Synonymous
   • Non-synonymous
3. Foundations of Genetics
   • One Locus
     • Genotype
     • Haploids vs. Diploids
     • Homo/heterozygosis, Allele Frequency
     • Dominant vs. Recessive: Blood Types
   • Random Mating: Hardy-Weinberg Equilibrium Non-random Mating
4. Genetic Drift
   • Dynamics in Population of Constants Size
   • N=1
   • Reduction of Heterozygosity
   • N>>1, Binomial Sampling
   • Probability of Fixation: Simulations1 simulations2
   • Time to Fixation
5. Selection
   • Absolute and Relative Fitness
   • Writes Equations: Increase of Fitness
6. Selection and Drift
   • Simulations
   • Probability of Fixation: (Diploids, s, N, h=1/2)
   • Time to Fixation
7. Summary