1 00:00:00,000 --> 00:00:01,100 2 00:00:01,100 --> 00:00:02,460 JOHN DOLHUN: You got the sock? 3 00:00:02,460 --> 00:00:03,960 OK. 4 00:00:03,960 --> 00:00:07,660 So I'm just going to put the sock in here. 5 00:00:07,660 --> 00:00:08,770 He's going to catch it. 6 00:00:08,770 --> 00:00:11,400 [LOUD POPPING NOISE] 7 00:00:11,400 --> 00:00:13,440 There it goes. 8 00:00:13,440 --> 00:00:15,200 Let's check his sock out. 9 00:00:15,200 --> 00:00:17,308 Is it still OK? 10 00:00:17,308 --> 00:00:55,290 [MUSIC PLAYING] 11 00:00:55,290 --> 00:00:57,260 NARRATOR: It's day one. 12 00:00:57,260 --> 00:01:00,440 MIT instructor John Dolhun introduces the course. 13 00:01:00,440 --> 00:01:03,640 JOHN DOLHUN: You're going to learn basic skills that will 14 00:01:03,640 --> 00:01:08,350 form building blocks in your future adventures at MIT and 15 00:01:08,350 --> 00:01:09,890 outside of MIT. 16 00:01:09,890 --> 00:01:13,250 NARRATOR: That is, if you pass. 17 00:01:13,250 --> 00:01:15,220 And what exactly does that take? 18 00:01:15,220 --> 00:01:18,500 JOHN DOLHUN: You're going to get about 14 hours of lecture, 19 00:01:18,500 --> 00:01:21,630 about 52 to 75 hours of lab. 20 00:01:21,630 --> 00:01:25,460 We only have two and a half weeks. 21 00:01:25,460 --> 00:01:30,230 You have to be able to think out of the box, be creative, 22 00:01:30,230 --> 00:01:34,720 and most importantly, be mindful of your mistakes. 23 00:01:34,720 --> 00:01:36,090 PHIL: The hoods are over there... 24 00:01:36,090 --> 00:01:38,290 NARRATOR: Next, safety training. 25 00:01:38,290 --> 00:01:41,030 Remember, for many of the students this is their first 26 00:01:41,030 --> 00:01:42,200 time in the lab. 27 00:01:42,200 --> 00:01:46,610 No flip-flops, no shorts, no skirts, but most importantly, 28 00:01:46,610 --> 00:01:48,760 gloves and goggles starting tomorrow. 29 00:01:48,760 --> 00:01:51,190 PHIL: They tell you to wear goggles and everything. 30 00:01:51,190 --> 00:01:53,460 And you don't really realize the importance until you have 31 00:01:53,460 --> 00:01:55,830 a piece of glass flying at your face. 32 00:01:55,830 --> 00:01:58,690 NARRATOR: After four hours of lecture, the students finally 33 00:01:58,690 --> 00:01:59,780 check into the lab. 34 00:01:59,780 --> 00:02:01,140 TENGFEI: My name is Tengfei. 35 00:02:01,140 --> 00:02:03,680 And this is Phil. 36 00:02:03,680 --> 00:02:06,900 And we will be the TAs for this class. 37 00:02:06,900 --> 00:02:10,554 This is all the equipment you should have in your drawer and 38 00:02:10,554 --> 00:02:11,288 the cabinet. 39 00:02:11,288 --> 00:02:22,046 [MUSIC PLAYING] 40 00:02:22,046 --> 00:02:22,372 AUDIENCE: Oh. 41 00:02:22,372 --> 00:02:23,530 Nevermind. 42 00:02:23,530 --> 00:02:26,050 ETHAN: I guess I get the antique shelf or something. 43 00:02:26,050 --> 00:02:28,480 But we'll work around it. 44 00:02:28,480 --> 00:02:33,340 45 00:02:33,340 --> 00:02:35,930 NARRATOR: After checking in, the students get introduced to 46 00:02:35,930 --> 00:02:37,670 a technique called nuclear magnetic 47 00:02:37,670 --> 00:02:40,860 resonance, or NMR for short. 48 00:02:40,860 --> 00:02:44,810 NMR helps chemists piece together a molecule structure. 49 00:02:44,810 --> 00:02:48,390 The students put their mystery molecule into a thin tube and 50 00:02:48,390 --> 00:02:51,810 lower it into a very powerful magnetic field. 51 00:02:51,810 --> 00:02:55,130 This forces certain atoms in the sample to align themselves 52 00:02:55,130 --> 00:02:57,930 either with or against the field. 53 00:02:57,930 --> 00:03:00,440 Aligning with the field takes less energy. 54 00:03:00,440 --> 00:03:02,810 So there are a few more atoms aligned with 55 00:03:02,810 --> 00:03:04,870 than against the field. 56 00:03:04,870 --> 00:03:07,580 A pulse of energy makes the extra atoms aligned with the 57 00:03:07,580 --> 00:03:09,290 field flip. 58 00:03:09,290 --> 00:03:12,470 The computer measures how much energy this takes and produces 59 00:03:12,470 --> 00:03:13,970 a spectrum. 60 00:03:13,970 --> 00:03:17,280 The amount of energy it takes to flip an atom depends on 61 00:03:17,280 --> 00:03:19,350 what other atoms are next to it. 62 00:03:19,350 --> 00:03:22,890 That means you can tell which of the atoms are connected and 63 00:03:22,890 --> 00:03:26,460 put together a picture of what the whole molecule looks like. 64 00:03:26,460 --> 00:03:27,890 That's the theory. 65 00:03:27,890 --> 00:03:30,290 But the students are about to learn that dealing with a real 66 00:03:30,290 --> 00:03:33,160 live machine is not so simple. 67 00:03:33,160 --> 00:03:34,447 ANNE RACHUPKA: Awful lot we're going to go over. 68 00:03:34,447 --> 00:03:36,395 These are live magnets. 69 00:03:36,395 --> 00:03:38,343 They are in field at all times. 70 00:03:38,343 --> 00:03:43,213 You cannot go anywhere near it with iPod, iPhone, any USB 71 00:03:43,213 --> 00:03:47,109 storage devices, no push pins, no staples, no bobby pins. 72 00:03:47,109 --> 00:03:49,070 We have our little sample? 73 00:03:49,070 --> 00:03:51,740 I have taken people to the hospital because they've put 74 00:03:51,740 --> 00:03:53,500 an NMR tube through their hand. 75 00:03:53,500 --> 00:03:56,380 Definitely don't bring your wallet anywhere near the 76 00:03:56,380 --> 00:03:56,860 instrument. 77 00:03:56,860 --> 00:04:00,230 This costs probably more than one year tuition to MIT. 78 00:04:00,230 --> 00:04:02,230 Obviously, this is not going to work. 79 00:04:02,230 --> 00:04:05,410 Do not, under any circumstances, insert your 80 00:04:05,410 --> 00:04:07,750 sample without the air on. 81 00:04:07,750 --> 00:04:09,430 You guys have any burning questions? 82 00:04:09,430 --> 00:04:11,610 You're all going to be experts the first time you sit down 83 00:04:11,610 --> 00:04:11,940 [INAUDIBLE]. 84 00:04:11,940 --> 00:04:12,660 Right? 85 00:04:12,660 --> 00:04:14,900 LEALIA: We were all like, uh-- 86 00:04:14,900 --> 00:04:15,680 ANTHONY: Mmm. 87 00:04:15,680 --> 00:04:16,800 ETHAN: Oh dear God. 88 00:04:16,800 --> 00:04:20,690 JULIE: Can we just not talk about this anymore? 89 00:04:20,690 --> 00:04:22,720 NARRATOR: The day is finally over. 90 00:04:22,720 --> 00:04:26,140 And it's time to head home. 91 00:04:26,140 --> 00:04:28,400 IKE: It was pretty intimidating because I walked 92 00:04:28,400 --> 00:04:30,440 into this class with all these smart people. 93 00:04:30,440 --> 00:04:32,410 ETHAN: I felt, I guess, a little bit overwhelmed. 94 00:04:32,410 --> 00:04:36,430 I wasn't exactly sure what to expect from 5.301. 95 00:04:36,430 --> 00:04:39,096 EMILY: I didn't expect it to be this much work. 96 00:04:39,096 --> 00:04:42,470 I'm kind of doubting whether I made the right choice to take 97 00:04:42,470 --> 00:04:43,370 this class. 98 00:04:43,370 --> 00:04:46,800 ETHAN: Oh my God, what have I gotten into ? 99 00:04:46,800 --> 00:04:48,980 ANTHONY: I am going to fail this class. 100 00:04:48,980 --> 00:04:57,400 [MUSIC PLAYING] 101 00:04:57,400 --> 00:04:58,620 SPEAKER: I've always been a fan of cupcakes. 102 00:04:58,620 --> 00:05:01,850 But now that they're popular, I'm a big fan of cupcakes. 103 00:05:01,850 --> 00:05:04,330 ANTHONY: Oh, can you make us dessert? 104 00:05:04,330 --> 00:05:05,040 SPEAKER: No. 105 00:05:05,040 --> 00:05:05,956 ANTHONY: Why not? 106 00:05:05,956 --> 00:05:07,540 SPEAKER: What is this, like an ice cream social? 107 00:05:07,540 --> 00:05:19,616 [MUSIC PLAYING]