1 Introduction and course overview

See the Lecture Summary

No Readings
2 Introduction to calorie restriction

See the Lecture Summary

Weindruch, R., R. L. Walford, et al. “The Retardation of Aging in Mice by Dietary Restriction: Longevity, Cancer, Immunity and Lifetime Energy Intake.” Journal of Nutrition 116 (1986): 641-54.

Colman, R. J., R. M. Anderson, et al. “Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys.” Science 325 (2009): 201-4.

3 Cellular senescence and telomerase

See the Lecture Summary

Allsopp, R. C., H. Vaziri, et al. “Telomere Length Predicts Replicative Capacity of Human Fibroblasts.” Proc Natl Acad Sci 89 (1992): 10114-18. (PDF - 1.4MB)

Rudolph, K. L., S. Chang, et al. “Longevity, Stress Response, and Cancer in Aging Telomerase-deficient Mice.” Cell 96 (1999): 701-12.

4 Premature aging syndromes

See the Lecture Summary

Varga, R., M. Eriksson, et al. “Progressive Vascular Smooth Muscle Cell Defects in a Mouse Model of Hutchinson-Gilford Progeria Syndrome.” Proc Natl Acad Sci 103 (2006): 3250-5. (PDF - 2.7MB)

Kujoth, G. C., A. Hiona, et al. “Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging.” Science 309 (2005): 481-4.

5 Lifespan extension in model organisms

See the Lecture Summary

Kennedy, B. K., N. R. Austriaco Jr., et al. “Mutation in the Silencing Gene SIR4 Can Delay Aging in S. cerevisiae.” Cell 80 (1995): 485-96.

Ayyadevara, S., C. Tazearslan, et al. “Caenorhabditis elegans PI3K Mutants Reveal Novel Genes Underlying Exceptional Stress Resistance and Lifespan.” Aging Cell 8 (2009): 706-25.

6 Sirtuins in lifespan extension

See the Lecture Summary

Kaeberlein, M., McVey M., et al. “The SIR2/3/4 Complex and SIR2 alone Promote Longevity in Saccharomyces cerevisiae by Two Different Mechanisms.” Genes Dev 13 (1999): 2570-80.

Herranz, D., M. Muñoz-Martin, et al. “Sirt1 Improves Healthy Ageing and Protects from Metabolic Syndrome-associated Cancer.” Nature Communnication 1 (2010): 1-8.

7 Tor in model organisms

See the Lecture Summary

Steffen, K. K., V. L. MacKay, et al. “Yeast Life Span Extension by Depletion of 60s Ribosomal Subunits is Mediated by Gcn4.” Cell 133 (2008): 292-302.

Hansen, M., S. Taubert, et al. “Lifespan Extension by Conditions that Inhibit Translation in Caenorhabditis elegans.” Aging Cell 6 (2007): 95-110.

8 Field trip to Boston Data Aging Club meeting at Harvard Medical School

No Readings
9 Oxidative stress theory of aging

See the Lecture Summary

Pérez, V. I., R. Buffenstein, et al. “Protein Stability and Resistance to Oxidative Stress are Determinants of Longevity in the Longest-living Rodent, the Naked Mole-rat.” Proc Natl Acad Sci 106 (2009): 3059-64. (PDF)

Schriner, S. E., N. J. Linford, et al. “Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria.” Science 308 (2005): 1909-11.

10 Oxidative stress and aging: beneficial effects

See the Lecture Summary

Schulz, T. J., K. Zarse, et al. “Glucose Restriction Extends C. elegans Life Span by Inducing Mitochondrial Respiration and Increasing Oxidative Stress.” Cell Metab 6 (2007): 280-93.

Lee, S-J, A. B. Hwang, et al. “Inhibition of Respiration Extends C. elegans Life Span via Reactive Oxygen Species that Increase HIF-1 Activity.” Current Biology 20 (2010): 2131-36.

11 Reversing aging with drugs; activating sirtuins with resveratrol

See the Lecture Summary

Baur, J. A., K. J. Pearson, et al. “Resveratrol Improves Health and Survival of Mice on a High-calorie Diet.” Nature 444 (2006): 337-42.

Um, J-H, S-J Park, et al. “AMP-Activated Protein Kinase-Deficient Mice are Resistant to the Metabolic Effects of Resveratrol.” Diabetes 59 (2010): 554-63. (PDF)

12 Student oral presentations

No Readings
13 Reversing aging with drugs; inhibiting the TOR pathway with rapamycin

See the Lecture Summary

Miller, R. A., D. E. Harrison, et al. “Rapamycin, but not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice.” J Gerontol A Biol Sci Med Sci 66 (2011): 191-201.

Spilman, P., N. Podlutskaya, et al. “Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-βeta Levels in a Mouse Model of Alzheimer’s Disease.” PLoS One 5 (2010): e9979.

Course Info
As Taught In
Fall 2011
Learning Resource Types
assignment Written Assignments
assignment Presentation Assignments