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Fundamentals of learning and memory: pre- and post-synaptic mechanisms

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Isaac, J. T., R. A. Nicoll, et al. “Evidence for Silent Synapses: Implications for the Expression of LTP.” Neuron 15, no. 2 (1995): 427–34.

Skrede, K. K., and Malthe-Sørenssen. “Increased Resting and Evoked Release of Transmitter Following Repetitive Electrical Tetanization in Hippocampus: A Biochemical Correlate to Long-Lasting Synaptic Potentiation.” Brain Research 208, no. 2 (1981): 436–41.


Mechanisms of learning: activity-regulated genes

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Nedivi, E., S. Fieldust, et al. “A Set of Genes Expressed in Response to Light in the Adult Cerebral Cortex and Regulated During Development.” Proceedings of the National Academyof Sciences of the United States of America 93, no. 5 (1996): 2048–53.

Chowdhury, S., J. Shepherd, et al. “Arc / Arg3.1 Interacts with the Endocytic Machinery to Regulate AMPA Receptor Trafficking.” Neuron 52, no. 3 (2006): 445–59.


Forms of Learning and Memory I: Procedural and Episodic

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Goshen, I., M. Brodsky, et al. “Dynamics of Retrieval Strategies for Remote Memories.” Cell 147, no. 3 (2011): 678–89.

Schonewille, M., A. Belmeguenai, et al. “Purkinje Cell-Specific Knockout of the Protein Phosphatase PP2B Impairs Potentiation and Cerebellar Motor Learning.” Neuron 67, no. 4 (2010): 618–28.


Forms of Learning and Memory II: Non-Associative vs. Associative

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Martin, K. C., A. Casadio, et al. “Synapse-Specific, Long-Term Facilitation of Aplysia Sensory to Motor Synapses: A Function for Local Protein Synthesis in Memory Storage.” Cell 91, no. 7 (1997): 927–38.

Marowsky, A., Y. Yanagawa, et al. “A Specialized Subclass of Interneurons Mediates Dopaminergic Facilitation of Amygdala Function.” Neuron 48, no. 6 (2005): 1025–37.


Lab visit – role of activity-regulated genes in experience-dependent plasticity

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Forms of Learning and Memory III: Drug Addiction and Perceptual Learning

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Argilli, E., D. Sibley, et al. “Mechanism and Time Course of Cocaine-Induced Long-Term Potentiation in the Ventral Tegmental Area.” The Journal of Neuroscience 28, no. 37 (2008): 9092–100.

Sale, A., R. De Pasquale, et al. “Visual Perceptual Learning Induces Long-Term Potentiation in the Visual Cortex.” Neuroscience 172 (2011): 219–25.


Learning through others’ experience and observational learning

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Jeon, D., S. Kim, et al. “[Observational Fear Learning Involves Affective Pain System and Cav1.2 Ca2+ Channels in ACC]( 10.1038/nn.2504).” Nature Neuroscience 13, no. 4 (2010): 482–8.

Dias, B. G., and K. J. Ressler. “Parental Olfactory Experience Influences Behavior and Neural Structure in Subsequent Generations.” Nature Neuroscience 17, no. 1 (2014): 89–96.


Synapse formation and stabilization

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Nägerl, U. V., G. Köstinger, et al. “Protracted Synaptogenesis after Activity-Dependent Spinogenesis in Hippocampal Neurons."The Journal of Neuroscience 27, no. 30 (2007): 8149–56.

Zito, K., V. Scheuss, et al. “Rapid Functional Maturation of Nascent Dendritic Spines.” Neuron 61, no. 2 (2009): 247–58.


Experience-dependent plasticity: Visual Cortex

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Cabelli, R. J., D. L. Shelton, et al. “Blockade of Endogenous Ligands of trkB Inhibits Formation of Ocular Dominance Columns.” Neuron 19, no. 1 (1997): 63–76.

Mrsic-Flogel, T. D., S. B. Hofer, et al. “Homeostatic Regulation of Eye-Specific Responses in Visual Cortex During Ocular Dominance Plasticity.” Neuron 54, no. 6 (2007): 961–72.


Occlusion of synaptic plasticity by learning

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Rioult-Pedotti, M. S., D. Friedman, et al. “Learning-Induced LTP in Neocortex.” Science 290, no. 5491 (2000): 533–6.

Whitlock, J. R., A. J. Heynen, et al. “Learning Induces Long-Term Potentiation in the Hippocampus.” Science 313, no. 5790 (2006): 1093–7.


Creating false memory, erasing specific memory

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Ramirez, S., X. Liu, et al. “Creating a False Memory in the Hippocampus.” Science 341, no. 6144 (2013): 387–91.

Han, J. H., S. A. Kushner, et al. “Selective Erasure of a Fear Memory.” Science 323, no. 5920 (2009): 1492–6.


Understanding a disease: Fragile X Syndrome

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Qin, M., J. Kang, et al. “Postadolescent Changes in Regional Cerebral Protein Synthesis: An In Vivo Study in the Fmr1 Null Mouse.” The Journal of Neuroscience 25, no. 20 (2005): 5087–95.

Osterweil, E. K., S. C. Chuang, et al. “Lovastatin Corrects Excess Protein Synthesis and Prevents Epileptogenesis in a Mouse Model of Fragile X Syndrome.” Neuron 77, no. 2 (2013): 243–50.


Oral presentations and course discussion

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