WEEK #	TOPICS	KEY DATES
1	Introduction
2	The Discovery of RNA Interference
3	The Basic Mechanism of RNAi
4	Physiological Relevance of the RNAi Pathway
5	Short-interfering RNAs (siRNAs) and their Delivery to Cells
6	Stable Expression of siRNA: Short Hairpins and Expression Vectors
7	Generation of Transgenic Animals for in vivo Silencing
8	Field Trip to Mouse-transgenesis Facility	Assignment 1 due
9	Discussion of First Written Assignment	Choose journal article papers for second assignment
10	Design of Potent siRNA Sequences
11	Large-scale Genetic Analyses Using RNAi
12	Student Oral Presentations of their Chosen Papers	Assignment 2 due
13	Using RNAi in the Prevention of Disease
14	Course Summary and Discussion on the Future of RNAi