1 Introduction

2 Scientific reading, writing and learning mechanisms of simple invertebrates

Dudai, Y., Y. N. Jan, D. Byers, W. G. Quinn, and S. Benzer. “Dunce, a Mutant of Drosophila Deficient in Learning.” Proc Natl Acad Sci USA 73 (1976): 1684-1688.

Carew, T. J., E. T. Walters, and E. R. Kandel. “Classical Conditioning in a Simple Withdrawal Reflex.” In Aplysia Californica J Neurosci 1 (1981): 1426-1437.

3 Synaptic plasticity in rodent hippocampal slices

Schwartzkroin, P. A., and K. Wester. “Long-lasting Facilitation of a Synaptic Potential Following Tetanization in the in vitro Hippocampal Slice.” Brain Res 89 (1975): 107-119.

Stanton, P. K., and J. M. Sarvey. “Blockade of Long-term Potentiation in Rat Hippocampal CA1 Region by Inhibitors of Protein Synthesis.” J Neurosci 4 (1984): 3080-3088.

4 Molecular mechanisms underlying LTP

Coan, E. J., W. Saywood, and G. L. Collingridge. “MK-801 Blocks NMDA Receptor-mediated Synaptic Transmission and Long Term Potentiation in Rat Hippocampal Slices.” Neurosci Lett 80 (1987): 111-114.

Hayashi, Y., S. H. Shi, J. A. Esteban, A. Piccini, J. C. Poncer, and R. Malinow. “Driving AMPA Receptors into Synapses by LTP and CaMKII: Requirement for GluR1 and PDZ Domain Interaction.” Science 287 (2000): 2262-2267.

5 Complicating the model of LTP

Dudek, S. M., and M. F. Bear. “Bidirectional Long-term Modification of Synaptic Effectiveness in the Adult and Immature Hippocampus.” J Neurosci 13 (1993): 2910-2918.

Borroni, A. M., H. Fichtenholtz, B. L. Woodside, and T. J. Teyler. “Role of Voltage-dependent Calcium Channel Long-term Potentiation (LTP) and NMDA LTP in Spatial Memory.” J Neurosci 20 (2000): 9272-9276.

6 The Morris water maze

Morris, R. “Developments of a Water-maze Procedure for Studying Spatial Learning in the Rat.” J Neurosci Methods 11 (1984): 47-60.

Halagappa, V. K., Z. Guo, M. Pearson, Y. Matsuoka, R. G. Cutler, F. M. Laferla, and M. P. Mattson. “Intermittent Fasting and Caloric Restriction Ameliorate Age-related Behavioral Deficits in the Triple-transgenic Mouse Model of Alzheimer’s Disease.” Neurobiol Dis 26 (2007): 212-220.

7 Place cells

O’Keefe, J., and J. Dostrovsky. “The Hippocampus as a Spatial Map. Preliminary Evidence from Unit Activity in the Freely-moving Rat.” Brain Res 34 (1971): 171-175.

Ji, D., and M. A. Wilson. “Coordinated Memory Replay in the Visual Cortex and Hippocampus During Sleep.” Nat Neurosci 10 (2007): 100-107.

8 Field trip

9 NMDA receptors and place cells

Tsien, J. Z., P. T. Huerta, and S. Tonegawa. “The Essential Role of Hippocampal CA1 NMDA Receptor-dependent Synaptic Plasticity in Spatial Memory.” Cell 87 (1996): 1327-1338.

McHugh, T. J., K. I. Blum, J. Z. Tsien, S. Tonegawa, and M. A. Wilson. “Impaired Hippocampal Representation of Space in CA1-specific NMDAR1 Knockout Mice.” Cell 87 (1996): 1339-1349.

10 Hippocampal representation of space in contextual fear conditioning

Wiltgen, B. J., M. J. Sanders, S. G. Anagnostaras, J. R. Sage, and M. S. Fanselow. “Context Fear Learning in the Absence of the Hippocampus.” J Neurosci 26 (2006): 5484-5491.

Moita, M. A., S. Rosis, Y, Zhou, J. E. LeDoux, and H. T. Blair. “Putting Fear in its Place: Remapping of Hippocampal Place Cells During Fear Conditioning.” J Neurosci 24 (2004): 7015-7023.

11 Synaptic tagging

Sajikumar, S., S. Navakkode, and J. U. Frey. “Identification of Compartment- and Process-specific Molecules Required for “Synaptic Tagging” During Long-term Potentiation and Long-term Depression in Hippocampal CA1.” J Neurosci 27 (2007): 5068-5080.

Kauderer, B. S., and E. R. Kandel. “Capture of a Protein Synthesis-dependent Component of Long-term Depression.” Proc Natl Acad Sci USA 97 (2000): 13342-13347.

12 Other aspects of place cells

Oler, J. A., and E. J. Markus. “Age-related Deficits in the Ability to Encode Contextual Change: A Place Cell Analysis.” Hippocampus 10 (2000): 338-350.

Hafting, T., M. Fyhn, S. Molden, M. B. Moser, and E. I. Moser. “Microstructure of a Spatial Map in the Entorhinal Cortex.” Nature 436 (2005): 801-806.

13 Does LTP really happen in the brain?

Whitlock, J. R., A. J. Heynen, M. G. Shuler, and M. F. Bear. “Learning Induces Long-term Potentiation in the Hippocampus.” Science 313 (2006): 1093-1097.

Barnes, C. A., M. W. Jung, B. L. McNaughton, D. L. Korol, K. Andreasson, and P. F.Worley. “LTP Saturation and Spatial Learning Disruption: Effects of Task Variables and Saturation Levels.” J Neurosci 14 (1994): 5793-5806.

14 Schemas’ of memory

Kim, J. J., and M. S. Fanselow. “Modality-specific Retrograde Amnesia of Fear.” Science 256 (1992): 675-677.

Tse, D., R. F. Langston, M. Kakeyama, I. Bethus, P. A. Spooner, E. R. Wood, M. P. Witter, and R. G. Morris. “Schemas and Memory Consolidation.” Science 316 (2007): 76-82.

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Fall 2007
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