WEEK #	TOPICS	READINGS
1	Host Sensors of Viral Infection-I See the Lecture Summary	No readings
2	Introduction and Course Overview See the Lecture Summary	Zeng, W., L. Sun, et al. “Reconstitution of the RIG-I Pathway Reveals a Signaling Role of Unanchored Polyubiquitin Chains in Innate Immunity.” Cell 141, no. 2 (2010): 315–30. Mibayashi, M., L. Martinez-Sobrido, et al. “Inhibition of Retinoic Acid-Inducible Gene I-Mediated Induction of Beta Interferon by the NS1 Protein of Influenza A Virus.” Journal of Virology 81, no. 2 (2007): 514–24.
3	Host Sensors of Viral Infection-II: The Road to IFN Production Runs through the Mitochondria. See the Lecture Summary	Kawai, T., K. Takahashi, et al. “IPS-1, An Adaptor Triggering RIG-I and Mda5-Mediated Yype-I Interferon Induction.” Nature Immunology 6, no. 10 (2005): 981–8. Li, XD., L. Sun, et al. “Hepatitis C Virus Protease NS3/4A Cleaves Mitochondrial Antiviral Signaling Protein Off the Mitochondria to Evade Innate Immunity.” Proceedings of the National Academy of Sciences 102, no. 49 (2005): 17717–22.
4	Secreted IFN – In the Extracellular Space, No One Can Hear You Scream See the Lecture Summary	Smith, T. J., and R. R. Wagner. “Rabbit Macrophage Interferons I. Conditions For Biosynthesis By Virus-Infected And Uninfected Cells.” Journal of Experimental Medicine 125, no. 4 (1967): 559–77. Alcamí, A., J. A. Symons, et al. “The Vaccinia Virus Soluble Alpha/Beta Interferon (IFN) Receptor Binds to the Cell Surface and Protects Cells from the Antiviral Effects of IFN.” Journal of Virology 74, no. 23 (2000): 11230–9.
5	Vaccines: We Win, Finally. Not So Fast See the Lecture Summary	Guirakhoo, F., J. Arroyo, et al. “Construction, Safety, and Immunogenicity in Nonhuman Primates of a Chimeric Yellow Fever-Dengue Virus Tetravalent Vaccine.” Journal of Virology 75, no. 16 (2001): 7290–304. Manley K., J. Anderson, et al. “Human Cytomegalovirus Escapes a Naturally Occurring Neutralizing Antibody by Incorporating It into Assembling Virions.” C_ell Host and Microbe_ 10, no. 3 (2011): 197–209.
6	Trip to Sanofi/Pasteur See the Lecture Summary	Field Trip—No Readings
7	A New Player in the Puzzle of Filovirus Entry into Host Cells See the Lecture Summary	Chandran, K., N. J. Sullivan, et al. “Endosomal Proteolysis of the Ebola Virus Glycoprotein Is Necessary for Infection.” Science 308, no. 5728 (2005): 1643–5. Carette, J. E., M. Raaben, et al. “Ebola Virus Entry Requires Cholesterol Transporter Niemann Pick-C1.” Nature 477, no. 7364 (2011): 340–3.
8	IFN Signaling: United STATs and the Rule of V See the Lecture Summary	Leung, S., S. A. Qureshi, et al. “Role of STAT2 in the Alpha Interferon Signaling Pathway.” Molecular and Cellular Biology 15, no. 3 (1995): 1312–7. Rodriguez, J. J., J. P. Parisien, et al. “Nipah Virus V Protein Evades Alpha and Gamma Interferons by Preventing STAT1 and STAT2 Activation and Nuclear Accumulation.” Journal of Virology 76, no. 22 (2002): 11476–83.
9	Mechanisms of Human Cytomegalovirus Infection and Restriction See the Lecture Summary	Chin, K., and P. Cresswell. “Viperin (cig5), An IFN-inducible Antiviral Protein Directly Induced By Human Cytomegalovirus.” Proceedings of the National Academy of Sciences 98, no. 26 (2001): 15125–30. Seo, J., R. Yaneva, et al. “Human Cytomegalovirus Directly Induces the Antiviral Protein Viperin to Enhance Infectivity.” Science 332, no. 6033 (2011):1093–7.
10	HIV Restriction Factors and Mechanism of Evasion See the Lecture Summary	Perez-Caballero, D., T. Zang, et al. “Tetherin Inhibits HIV-1 Release by Directly Tethering Virions to Cells.” Cell 139, no. 3 (2009): 499–511. Mitchell, R. S., C. Katsura, et al. “Vpu Antagonizes BST-2–Mediated Restriction of HIV-1 Release via β-TrCP and Endo-Lysosomal Trafficking.” PLoS Pathogens 5, no. 5 (2009): e1000450.
11	Interferon-Induced Transmembrane (IFITM) Proteins as Restriction Factors for Influenza Virus See the Lecture Summary	Brass, A. L., I. Huang, et al. “The IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue Virus.” Cell 139, no. 7 (2009): 1243–54. Everitt A. R., S. Clare, et al. “IFITM3 Restricts The Morbidity and Mortality Associated With Influenza.” Nature 484, no. 7395 (2012): 519–23.
12	End-Term Final Assignment See the Lecture Summary	Final Assignment Due—No Readings