1 Introduction
2 Discovery of the Ubiquitin Conjugation System
3 Protein Degradation in Trafficking Membranes I: Endoplasmic Reticulum Associated Degradation (ERAD) Pathway
4 Protein Degradation in Trafficking Membranes II: Endocytosis and Lysosomal Degradation
5 Role of Ubiquitination in Transcriptional Regulation
6 Role of Ubiquitination in Cell Cycle Control and Programmed Cell Death
7 Ubiquitin-Like Proteins Assignment 1 due
8 Functions of the Ubiquitin-Proteasome System in the Immune System
9 Ubiquitin and Cancer
10 Ubiquitin and Neurodegenerative Diseases: Alzheimer's and Parkinson's Diseases
11 More Diseases Involving Ubiquitin: Huntington's and Von Hippel-Lindau Disease
12 Too Much Degradation Can Be as Bad as Not Enough: Cystic Fibrosis and Liddle's Syndrome
13 Potential Therapeutic Strategies in Ubiquitin-Related Diseases Assignment 2 due
14 Oral Presentations

Final Comments and Course Evaluation