In each class session, one student gives a presentation on an assigned paper. The following table lists the assigned papers for each session.
|LEC #||TOPICS||PAPERS USED IN STUDENT PRESENTATIONS|
|1||Ion channels I||None|
|2||Ion channels II||Doyle, Declan A., J. M. Cabral, R. A. Pfuetzner, et al. "The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity." Science 280 (April 3, 1998): 69-77.|
|3||Receptors I||Corey, David P., Jaime Garcia-Anoveros, Jeffrey R. Holt, et al. "TRPA1 is a Candidate for the Mechanosensitive Transduction Channel of Vertebrate Hair Cells." Nature 432 (December 9, 2004): 723-730.|
|4||Receptors II||He, Li, Jamie Fong, Mark von Zastrow, and Jennifer L. Whistler. "Regulation of Opioid Receptor Trafficking and Morphine Tolerance by Receptor Oligomerization." Cell 108 (January 25, 2002): 271-282.|
|5||Introduction; basics of electrophysiology||Mayer, Mark L., Gary L. Westbrook, and Peter B. Guthrie. "Voltage-dependent Block by Mg2+ of NMDA Responses in Spinal Cord Neurons." Nature 309 (May 17, 1984): 261-263.|
|6||Modulation of receptor activity||Bibb, James A., Gretchen L. Snyder, Akinori Nishi, et al. "Phosphorylation of DARPP-32 by Cdk5 Modulates Dopamine Signaling in Neurons." Nature 402 (December 9, 1999): 669-671.|
|7||Protein targeting, signaling complexes||Tsunoda, Susan, Jimena Sierralta, Yumei Sun, et al. "A Multivalent PDZ-domain Protein Assembles Signaling Complexes in a G-Protein-coupled Cascade." Nature 388 (July 17, 1997): 243-249.|
|8||Neuronal polarity / subcellular specialization||Fivaz, Marc, Samuel Bandara, Takanari Inoue, and Tobias Meyer. "Robust Neuronal Symmetry Breaking by Ras-Triggered Local Positive Feedback." Nature 388 (July 17, 1997): 243-249.|
|9||Repertoire of neuron interactions||Flames, Nuria, Jason E. Long, Alistair N. Garratt, et al. "Short- and Long-range Attraction of Cortical GABAergic Interneurons by Neuregulin-1." Neuron 44 (October 14, 2004): 251-261.|
|10||Neurogenesis||Xie, Zhigang, et al. "Cep120 and TACCs Control Interkinetic Nuclear |
Migration and the Neural Progenitor Pool." Neuron 56 (October 4, 2007): 79-93.
|11||Presynaptic mechanisms||Yoshihara, Motojiro, and J. Troy Littleton. "Synaptotagmin I Functions as a Calcium Sensor to Synchronize Neurotransmitter Release." Neuron 36 (December 5, 2002): 897-908.|
|12||Molecular manipulation of neural circuits|| |
Callaway, Edward M. "A Molecular and Genetic Arsenal for Systems Neuroscience." TRENDS in Neurosciences 28, no. 4 (April 2005): 196-201.
DeFalco, Jeff, Mark Tomishima, Hongyan Liu, et al. "Virus-assisted Mapping of Neural Inputs to a Feeding Center in the Hypothalamus." Science 291 (March 30, 2001): 2608-2613.
Nakashiba, Toshiaki, Jennie Z. Young, Thomas J. McHugh, et al. "Transgenic Inhibition of Synaptic Transmission Reveals Role of CA3 Output in Hippocampal Learning." Science 319, no. 5867 (February 29, 2008): 1260-1264.
Boyden Edward S., Feng Zhang, Ernst Bamberg, et al. "Millisecond-timescale, Genetically Targeted Optical Control of Neural Activity." Nature Neuroscience 8, no. 9 (September 2005): 1263-1268.
Karpova, Alla Y., Dougal G. R. Tervo, Noah W. Gray, et al. "Rapid and Reversible Chemical Neurotechnique Inactivation of Synaptic Transmission in Genetically Targeted Neurons." Neuron 48, no. 5 (December 8, 2005): 727-735.
Tan, Elaine M., Yoshiaki Yamaguchi, Gregory D. Horwitz, et al. "Selective and Quickly Neurotechnique Reversible Inactivation of Mammalian Neurons In vivo Using the Drosophila Allatostatin Receptor." Neuron 51, no. 2 (July 20, 2006): 157-170.
|13||Axon guidance||Hedgecock, Edward M., Joseph G. Culotti, and David H. Hall. "The unc-5, unc-6, and unc-40 Genes Guide Circumferential Migrations of Pioneer Axons and Mesodermal Cells on the Epidermis in C. elegans." Neuron 4, no. 1 (January 1990): 61-85.|
|14||Synapse formation/elimination||Kasthuri, Narayanan, and Jeff W. Lichtman. "The Role of Neuronal Identity in Synaptic Competition." Nature 424 (July 24, 2003): 426-430.|
|15||Trophic factors||Zhang, Xiao-hui, and Mu-ming Poo. "Localized Synaptic Potentiation by BDNF Requires Local Protein Synthesis in the Developing Axon." Neuron 36, no. 4 (November 14, 2002): 675-688.|
|16||Postsynaptic mechanisms; LTP/LTD||Shi, Song-Hai, Yasunori Hayashi, Jose A. Esteban, et al. "Subunit-Specific Rules Governing AMPA Receptor Trafficking to Synapses in Hippocampal Pyramidal Neurons." Cell 105, no. 3 (May 4, 2001): 331-343.|
|17||Waves and chemoaffinity||McLaughlin, Todd, Christine L. Torborg, Marla B. Feller, et al. "Retinotopic Map Refinement Requires Spontaneous Retinal Waves during a Brief Critical Period of Development." Neuron 40, no. 6 (December 18, 2003): 1147–1160.|
|18||Two faces of GABA||Gulledge, Allan T., and Greg J. Stuart. "Excitatory Actions of GABA in the Cortex." Neuron 37, no. 2 (January 23, 2003): 299-309.|
|19||Hodgkin and Huxley (lecture 1)||Long, Stephen B., Xiao Tao, Ernest B. Campbell, and Roderick MacKinnon. "Atomic Structure of a Voltage-dependent K+ Channel in a Lipid Membrane-like Environment." Nature 450 (November 15, 2007).|
|20||Hodgkin and Huxley (lecture 2)||Zagotta, William N., Toshinori Hoshi, and Richard W. Aldrich. "Restoration of Inactivation in Mutants of Shaker Potassium Channels by a Peptide Derived from ShB." Science 250, no. 4980 (October 26, 1990): 568-571.|
|21||Aplysia learning||Lee, Seung-Hee, Chae-Seok Lim, Hyungju Park, et al. "Nuclear Translocation of CAM-Associated Protein Activates Transcription for Long-Term Facilitation in Aplysia." Cell 129, no. 4 (May 18, 2007): 801-812.|
|22||Drosophila learning||Yu, Dinghui, Alex C. Keene, Anjana Srivatsan, et al. "Drosophila DPM Neurons Form a Delayed and Branch-Specific Memory Trace after Olfactory Classical Conditioning." Cell 123, no. 5 (December 2, 2005): 945-957.|
|23||Drosophila circadian rhythms||Shafer, Orie T., Dong Jo Kim, Richard Dunbar-Yaffe, et al. "Widespread Receptivity to Neuropeptide PDF throughout the Neuronal Circadian Clock Network of Drosophila Revealed by Real-Time Cyclic AMP Imaging." Neuron 58, no. 2 (April 24, 2008): 223-237.|
|24||Epilepsy||Khalilov, Ilgam, Gregory L. Holmes, and Yehezkel Ben-Ari. "In vitro formation of a Secondary Epileptogenic Mirror Focus by Interhippocampal Propagation of Seizures." Nature Neuroscience 6, no. 10 (October 2003): 1079-1085.|