Design of Medical Devices and Implants

Lecture Notes

LEC #	TOPICS	INSTRUCTORS	LECTURE NOTES
I. Principles Of Implant Design (Working Paradigms)
1	Clinical Problems Requiring Implants for Solution	I. V. Yannas / M. Spector	Overview Slides (PDF - 1.2 MB) Four Design Principles for Medical Devices (PDF)
2	Principles of Implant Design / Design Parameters: Permanent versus Absorbable Devices	I. V. Yannas / M. Spector
3	The Missing Organ and its Replacement	I. V. Yannas	The Problem of the Missing Organ (PDF)
4	Criteria for Materials Selection	I. V. Yannas
5	Tissue Engineering I: Scaffolds	M. Spector	Tissue Engineering I: Overview (PDF - 1.4 MB) Tissue Engineering II: Scaffolds (PDF - 1.4 MB)
6	Tissue Engineering II: Cells and Regulators	M. Spector	Tissue Engineering III: Growth Factors and Genes (PDF - 1.3 MB) Tissue Engineering IV: Stem Cells (PDF - 1.2 MB)
7	Case Study of Organ Regeneration	I. V. Yannas	Design Case Study: Device for Partial Regeneration of Skin (PDF)
II. Design Parameters
8	Design Specifications: Biomaterials Survey	M. Spector	Biomaterials Survey (PDF) Implant Fixation, Mechanical Stability and Modulus Matching (PDF - 1.2 MB)
	Quiz
9	Biocompatibility: Local and Systemic Effects	M. Spector	Biocompatibility (PDF - 1.3 MB)
10	Design Specifications: Tissue Bonding and Modulus Matching	M. Spector
11	Degradation of Devices: Natural and Synthetic Polymers	I. V. Yannas
12	Biocompatibility: Scar Formation and Contraction	I. V. Yannas	Scar Formation Around Implants (PDF)
13	Degradation of Devices: Corrosion and Wear	M. Spector	Degradation of Devices: Corrosion and Wear (PDF)
14	Federal Regulation of Devices I	M. Spector	Federal Regulation of Medical Devices (PDF - 1.2 MB) Recommended Biocompatibility Testing and Regulation of Tissue Engineered Products (PDF - 1.0 MB) Summary of Federal Regulatory Issues and Clinical Trials (PDF - 1.1 MB)
15	Oral Presentations of Proposals for Design II	I. V. Yannas / M. Spector
16	Federal Regulation of Devices II	M. Spector
III. Design Solution In-use
17	Scaffolds for Cartilage Repair	S. Vickers	Statistics: Type I and Type II errors (PDF)
18	Implants for Bone	M. Spector	Bone Substitute Materials and Tissue Engineering (PDF - 1.4 MB)
19	Implants for Plastic Surgery	Dr. D. P. Orgill
20	Cardiovascular Prostheses: Heart Valves and Blood Vessels	Dr. F. Schoe
21	Devices for Nerve Regeneration	I. V. Yannas
22	Musculoskeletal Soft Tissues: Meniscus, Intervertebral Disk	M. Spector
23	Dental and Otologic Implants	M. Spector	Dental Tissue Engineering (PDF)
24	Other Devices: Spinal Cord, Heart Lung	M. Spector
25	Final Oral Presentation of Designs (Mock FDA Panel)