Thermodynamics of Biomolecular Systems

Calendar

LEC #	TOPICS	KEY DATES
1	Introduction to Thermo; 0th Law; Temperature; Work; Heat
2	State Functions, 1st Law, Paths
3	Joule and Joule-Thompson; Heat Capacity
4	Reversible and Irreversible Processes
5	Thermochemistry	Problem set 1 due
6	2nd Law; Entropy (Boltzmann and Clausius)
7	ΔS for Reversible and Irreversible Processes	Problem set 2 due
8	Equilibrium; Maxwell Relations; Free Energy
9	Chemical Potential; Phase Equilibrium
10	Chemical Equilibrium; Equilibrium Constant	Problem set 3 due
11	Standard States; Gibbs-Duhem
12	ΔG0= -RTlnK; Example
	Hour Exam 1
13	Boltzmann Distribution
14	Thermo and Boltzmann Distribution	Problem set 4 due
15	Occupation of States
16	Third Law
17	Phase Equilibria, Single Component	Problem set 5 due
18	Phase Equilibria II; Clausius Clapeyron
19	Regular Solutions; Mixing Energy; Mean Fields
20	Nonideal Solutions	Problem set 6 due
21	Solvation; Colligative Properties
	Hour Exam 2
22	Osmotic Pressure and Phase Partitioning
23	Surface Tension
24	Polymer 1 - Freely Jointed Chain	Problem set 7 due
25	Polymer 2 - Chain Conformation
26	Polymer 3 - Rubber Elasticity
27	Electrolyte Solutions	Problem set 8 due
28	Electrolytes at Interfaces; Debye Length
29	Titration of Polyelectrolytes
30	Thermodynamics of DNA Hybridization	Problem set 9 due
31	Cooperativity
	Hour Exam 3
32	Cooperativity, Part 2
33	Cooperativity, Part 3
34	Driving Forces for Self-Assembly	Problem set 10 due
35	Special Topic (Coarse Grain/Monte Carlo Model)
36	Course Review and Evaluations