20.201 | Fall 2013 | Graduate

Mechanisms of Drug Actions


Session Key

L = Lecture

R = Recitation

E = Exam

Lecturer Key

PD = Prof. Peter Dedon

MM = Dr. Mark Murcko

ST = Prof. Steven Tannenbaum

  CK = Dr. Charles Knutson

  GL = Guest lecturer

  TA = Teaching assistants

Overview of the Drug Discovery Process; Fundamental Principles
L1 Introduction and Fundamentals PD, MM, ST  
L2 Overview of Drug Development 1 MM  
L3 Overview of Drug Development 2 MM  
R1 Fundamentals PD  
L4 Biochemistry Review Exercise CK  
L5 Uptake and Distribution PD  
L6 Dr. Keith Hoffmaster, Novartis: Drug Transporters 1 GL  
L7 Dr. Keith Hoffmaster, Novartis: Drug Transporters 2 GL Drug Metabolism Problem Sets Due
R2 Drug Metabolism 1 ST  
L8 Drug Metabolism 2 ST  
L9 Drug Toxicity 1 ST  
R3 Lecture Review Session TA  
L10 Drug Toxicity 2 ST  
L11 Pharmacokinetics PD  
R4 Quiz Review PD, TA

Fundamentals Problem Set Due

Pharmacokinetics Problem Set Due

E Exam
Case Studies and Literature Discussions; Case Study Project
L12 Case Study: Omeprazole Pharmacogenetics PD  
R5 Overview of Drug Development 3 MM Case Study Project Topic Due
L13 Case Study MM  
L14 Case Study: Antibiotics CK  
R6 Project Help Session TA  
L15 Case Study ST  
L16 Dr. Alex Wood, MIT Senior Lecturer / Novartis: Case Study: Oncology Drugs GL  
R7 Project Help Session TA  
L17 Case Study: Statins PD  
R8 Project Help Session TA  
L18 Case Study: GWAS and Statin Toxicity PD  
L19 Dr. Bernard Fermini, Pfizer: Case Study: Cardiotoxicity GL  
R9 Project Help Session TA  
L20 Dr. Teresa Wright, Shire Pharmaceuticals: Preclinical Drug Development GL  
R10 Project Help Session TA  
L21 Dr. Keith Hoffmaster: Case Study: PK / PD GL  
L22 Case Study: Sarilumab Phase III Clinical Result MM  
R11 Prof. Doug Lauffenburger: Systems Pharmacology GL  
L23 Dr. Tess Schmalbach, Schmalbach LLC: The Clinical Size of Drug Development GL Case Study Project Paper Due

Course Info

Learning Resource Types
Problem Sets with Solutions
Exams with Solutions
Lecture Notes
Projects with Examples
Written Assignments
Instructor Insights