Analysis of Biological Networks (BE.440)

Calendar

LEC #	TOPICS
1	Course Introduction Model networks involved in signaling - Signals that start outside of the cell (role of the ECM) and trigger cascades inside the cell, ultimately affecting gene expression
2	Information flow in the reverse direction - from DNA to RNA to protein (the central dogma) Review of regulatory circuits and introduction to the concept of evolutionary genomics Key Issues: DNA replication and repair errors lead to mutations. Loss of mismatch repair leads to a hyper-Rec phenotype, which facilitates horizontal gene transfer (antibiotic resistance, etc.)
3	Decoding Information I (Transcription Regulation)
4	Modeling Macromolecular Structure I Individual Homework Assignments
5	Decoding Information II (Translation)
6	Modeling Macromolecular Structure II Students Present Homework
7	Roundtable Discussion
	Examination 1
8	How to Write an NIH Grant Proposal
9	Analysis of the Interferon Network (The JAK/STAT System)
10	Analysis of the Interferon Network
11	Analysis of the Interferon Network (cont.)
12	Analysis of the Interferon Network (cont.)
13	Roundtable 1: Students Present Model Projects on Apoptosis
14	Chemotaxis I - How Salvage Pathways Supplement Core Biochemical Pathways The Che System Receptor Methylation as a Mechanism of Control of Chemotaxis
15	Chemotaxis II - How CheY(P) Signals to the Flagellar Motor Chemiosmotic Coupling Chemotaxis III. Proton Pumps
16	Introduction to the Extracellular Matrix Roundtable 2 Will be Delayed for a Few Weeks
17	Epithelial Cell Morphogenesis Signaling Hierarchy I
18	Epithelial Cell Morphogenesis Signaling Hierarchy II
19	Round Table Discussion
20	Epithelial Cell Morphogenesis Signaling Hierarchy III
	Examination 2
21	Roundtable 3
22	Changes in Lung Epithelium During Pathogenesis I
23	Changes in Lung Epithelium During Pathogenesis II
24	Network Example: Functional Glycomics
	Final Papers Due