20.450 | Spring 2005 | Graduate

Molecular and Cellular Pathophysiology (BE.450)


Required Readings

Many of the readings for this course come from the following text:

Kumar, Vinay, Abul K. Abbas, and Nelson Fausto, eds. Robbins and Cotran Pathologic Basis of Disease. 7th ed. Philadelphia, PA: Elsevier Saunders, 2004. ISBN: 9780721601878.

1 Introduction to 20.450 and HCC

Sherlock, G. “Analysis of large-scale gene expression data.” Current Opinion in Immunology 12, no. 2 (April 2000): 201-5. Review.

HBV slideset from the CDC

2-3 Cellular Pathology “Cellular Adaptations, Cell Injury, and Cell Death.” Chapter 1 in Robbins and Cotran. pp. 3-46.
4-5 Inflammation

“Acute and Chronic Inflammation. Chapter 2 in Robbins and Cotran. pp. 47-86.

Coussens, L. M., and Z. Werb. “Inflammation and cancer.” Nature 420, no. 6917 (December 19-26, 2002): 860-7. Review.

Muller, A., et al. “Involvement of chemokine receptors in breast cancer metastasis.” Nature 410, no. 6824 (March 1, 2001): 50-6.

Liotta, L. A. “An attractive force in metastasis.” Nature 410, no. 6824 (March 1, 2001): 24-5.

6 Liver Anatomy and Histology

“Liver and Biliary Tract.” Chapter 18 in Robbins and Cotran. pp. 878-879.

“Tissue Renewal and Repair: Regeneration, Healing, and Fibrosis.” Chapter 3 in Robbins and Cotran. pp. 87-118.

7-9 Immunity

“Diseases of Immunity.” Chapter 6 in Robbins and Cotran. pp. 193-240.

Prasad, S. J., et al. “Dendritic cells loaded with stressed tumor cells elicit long-lasting protective tumor immunity in mice depleted of CD4+CD25+ regulatory T cells.” Journal of Immunology 174, no. 1 (January 1, 2005): 90-8.

Rehermann, B., and M. Nascimbeni. “Immunology of hepatitis B virus and hepatitis C virus infection.” Nature Review Immunology 5, no. 3 (March 2005): 215-29.

Crispe, I. N. “Hepatic T cells and liver tolerance.” Nature Review Immunology 3, no. 1 (January 2003): 51-62.

10 Neoplasia

“Neoplasia.” Chapter 7 in Robbins and Cotran. pp. 269-339.

Li, et al. “Accurate qualitative and quantitative proteomic analysis of clinical hepatocellular carcinoma using laser capture microdissection coupled with isotope-coded affinity tag and two-dimensional liquid chromatography mass spectrometry.” Molecular and Cellular Proteomics 3, no. 4 (April 2004): 399-409.

Ding, S. J., et al. “From proteomic analysis to clinical significance: overexpression of cytokeratin 19 correlates with hepatocellular carcinoma metastasis.” Molecular and Cellular Proteomics 3, no. 1 (January 2004): 73-81.

Staib, F., S. P. Hussain, L. J. Hofseth, X. W. Wang, and C. C. Harris. “TP53 and liver carcinogenesis.” Human Mutation 21, no. 3 (March 2003): 201-16. Review.

  Midterm Exam  
11 Neoplasia (cont.) See readings for above Neoplasia lecture
12-13 Infectious Diseases “Infectious Diseases.” Chapter 8 in Robbins and Cotran. pp. 343-411.
14 Liver and Biliary

“Liver and Biliary Tract.” Chapter 18 in Robbins and Cotran. pp. 877-936.

Carey, M. C., R. S. Kwon, K. J. Maurer, and J. G. Fox. “State of the art - gallstone research in the post-genomic era.” Falk Symposium 139 (2004): 207-25.

Rogers, A. B., and J. G. Fox. “Inflammation and Cancer. I. Rodent models of infectious gastrointestinal and liver cancer.” American Journal of Physiology - Gastrointestinal and Liver Physiology 286, no. 3 (March 2004): G361-6. Review.

15-16 Hepatocarcinogenesis

Iizuka, N., et al. “Self-organizing-map-based molecular signature representing the development of hepatocellular carcinoma.” FEBS Letters 579, no. 5 (February 14, 2005): 1089-100.

Wielockx, B., K. Lannoy, S. D. Shapiro, T. Itoh, S. Itohara, J. Vandekerckhove, and C. Libert. “Inhibition of matrix metalloproteinases blocks lethal hepatitis and apoptosis induced by tumor necrosis factor and allows safe antitumor therapy.” Nature Medicine 7, no. 11 (November 2001): 1202-8.

Benyon, R. C., and M. J. Arthur. “Extracellular matrix degradation and the role of hepatic stellate cells.” Seminars in Liver Disease 21, no. 3 (August 2001): 373-84.

Kensler, T. W., P. A. Egner, J. B. Wang, Y. R. Zhu, B. C. Zhang, P. X. Lu, J. G. Chen, G. S. Qian, S. Y. Kuang, P. E. Jackson, S. J. Gange, L. P. Jacobson, A. Munoz, and J. D. Groopman. “Chemoprevention of hepatocellular carcinoma in aflatoxin endemic areas.” Gastroenterology 127, no. 5 Suppl. 1 (November 2004): S310-8.

17-18 Animal Models  
19-22 Special Topic  
  Final Exam  

Course Info

As Taught In
Spring 2005
Learning Resource Types
Problem Sets
Lecture Notes