Lecture slides on Risk-Informed Design Guidance for Gen IV Reactors, Technology-Neutral Regulatory Framework, Defense in Depth, Protective Strategies, Frequency-Consequence Curve, Licensing Basis Events, The MIT Risk-Informed Design Process, PRA as a Design Tool, Evolution of a Design and PRA, Applications, ECCS Designs 1-6 (LOCA), Results of the Iterative ECCS Design Guidance, and Screening based on Probabilistic Goals.