7.22 | Fall 2005 | Undergraduate

Developmental Biology


A list of recommended texts are included below the session wise readings list.

1 Development and Evolution: Introduction - Prof. Hazel Sive Weaver, C., and D. Kimelman. “Move it or lose it: axis specification in Xenopus.” Development 131, no. 15. (August 2004): 3491-9.

Yost, C., G. H. Farr, 3rd, S. B. Pierce, D. M. Ferkey, M. M. Chen, and D. Kimelman. “GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis.” Cell 93, no. 6 (June 12, 1998): 1031-41.

2 Development and Evolution: Introduction (cont.), Dorsoventral Axis - Prof. Hazel Sive  
3 Student Led Discussion Presentation: Vertebrate Development I Kudoh, T., S. W. Wilson, and I. B. Dawid. “Distinct roles for Fgf, Wnt and retinoic acid in posteriorizing the neural ectoderm.” Development 129, no. 18 (September 2002): 4335-46.

Niehrs, C. “Regionally specific induction by the Spemann-Mangold organizer.” Nat Rev Genet 5, no. 6 (June 2004): 425-34.

4 Dorsoventral Axis (II), Anteroposterior Axis - Prof. Hazel Sive  
5 Student Led Discussion Presentation: Vertebrate Development II Vetter, Monica L. and Richard I. Dorsky. “Neurogenesis.” Chapter 5 in Developmental Neurobiology. Edited by Mahendra S. Rao, and Marcus Jacobson. 4th ed. New York, NY: Springer-Verlag, 2005. ISBN: 9780306483301.
6 Nervous System: Background Descriptive, Morphogenesis - Prof. Martha Constantine-Paton  
7 Student Led Discussion Presentation: Nervous System I Grandbarbe, L., J. Bouissac, M. Rand, M. Hrabe de Angelis, S. Artavanis-Tsakonas, and E. D. Mohier. “Delta-Notch signaling controls the generation of neurons/glia from neural stem cells in a stepwise process.” Development 130, no. 7 (April 2003): 1391-402.
8 Embryonic Left-Right Asymmetry: A Fundamental Problem of Patterning Bearing on Cell, Developmental, and Evolutionary Biology - Guest Lecturer: Dr. Michael Levin, The Forsyth Institute and Harvard School of Dental Medicine  
9 Student Led Discussion Presentation: Left/Right Axis Levin, M. “The embryonic origins of left-right asymmetry.” Crit Rev Oral Biol Med 15, no. 4 (July 1, 2004): 197-206.

Supp, D. M., M. Brueckner, M. R. Kuehn, D. P. Witte, L. A. Lowe, J. McGrath, J. Corrales, and S. S. Potter. “Targeted deletion of the ATP binding domain of left-right dynein confirms its role in specifying development of left-right asymmetries.” Development 126, no. 23 (December 1999): 5495-504.

10 Neural Development: Patterning Cell Types in the Spinal Cord - Prof. Martha Constantine-Paton  
11 Student Led Discussion Presentation: Nervous System II Dasen, J. S., J. P. Liu, and T. M. Jessel. “Motor neuron columnar fate imposed by sequential phases of Hox-c activity.” Nature 425, no. 6961 (October 30, 2003): 926-33.

Appel, B., and J. S. Eisen. “Retinoids run rampant: multiple roles during spinal cord and motor neuron development.” Neuron. 40, no. 3 (October 30, 2003): 461-4.

12 Student Led Discussion Presentation: Nervous System III Pasquale, E. B. “Eph receptor signalling casts a wide net on cell behaviour.” Nat Rev Mol Cell Biol 6, no. 6 (June 2005): 462-75.

Huberman, A. D., K. D. Murray, D. K. Warland, D. A. Feldheim, and B. Chapman. “Ephrin-As mediate targeting of eye-specific projections to the lateral geniculate nucleus.” Nat Neurosci 8, no. 8 (August 2005): 1013-21. (Epub July 17, 2005.)

Charron, F., and M. Tessier-Lavigne. “Novel brain wiring functions for classical morphogens: a role as graded positional cues in axon guidance.” Development 132, no. 10 (May 2005): 2251-62.

Zou, Y., E. Stoeckli, H. Chen, and M. Tessier-Lavigne. “Squeezing axons out of the gray matter: a role for slit and semaphorin proteins from midline and ventral spinal cord.” Cell 102, no. 3 (August 4, 2000): 363-75.

13 Organogenesis - Guest Lecturer: Dr. Thomas M. Schultheiss, Harvard Medical School  
14 Student Led Discussion Presentation: Organogenesis Alsan, B. H., and T. M. Schultheiss. “Regulation of avian cardiogenesis by Fgf8 signaling.” Development 129, no. 8 (April 2002): 1935-43.

Carroll, T. J., J. S. Park, S. Hayashi, A. Majumdar, and A. P. McMahon. “Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system.” Dev Cell 9, no. 2 (August 2005): 283-92.

Dressler, G. “Tubulogenesis in the developing mammalian kidney.” Trends Cell Biol 12, no. 8 (August 2002): 390-5.

Zaffran, S., and M. Frasch. “Early signals in cardiac development.” Circ Res 91, no. 6 (September 20, 2002): 457-69.

15 Finding a Morphogen Gradient Using Forward Genetics: Dorsal-ventral Patterning by BMPs in Drosophila Embryos - Guest lecturer: Dr. Laurel Raftery, MGH/Harvard Medical School  
16 Student Led Discussion Presentation: Drosophila Blair, S. S. “Lineage compartments in Drosophila.” Curr Biol 13, no. 14 (July 15, 2003): R548-51.

Gurdon, J. B., and P. Y. Bourillot. “Morphogen gradient interpretation.” Nature 413, no. 6858 (October 25, 2001): 797-803.

Nellen, D., R. Burke, G. Struhl, and K. Basler. “Direct and long-range action of a DPP morphogen gradient.” Cell 85, no. 3 (May 3, 1996): 357-68.

17 Morphogenesis: Building 3D Structure - Prof. Hazel Sive  
18 Student Led Discussion Presentation: Morphogenesis Wallingford, J. B., R. M. Harland. “Xenopus Dishevelled signaling regulates both neural and mesodermal convergent extension: parallel forces elongating the body axis.” Development 128, no. 13 (July, 2001): 2581-92.

Strutt, D. “Frizzled signalling and cell polarisation in Drosophila and vertebrates.” Development 130, no. 19 (October 2003): 4501-13.

19 Stem Cells: Units of Development and Regeneration - Guest lecturer: Dr. Fernando D. Camargo, Whitehead Institute for Biomedical Research  
20 Student Led Discussion Presentation: Stem Cells Fuchs, E., T. Tumbar, and G. Guasch. “Socializing with the neighbors: stem cells and their niche.” Cell 116, no. 6 (March 19, 2004): 769-78.

Benitah, S. A., M. Frye, M. Glogauer, and F. M. Watt. “Stem cell depletion through epidermal deletion of Rac1.” Science 309, no. 5736 (August 5, 2005): 933-5.

Dotto, G. P., and G. Cotsarelis. “Developmental biology: Rac1 up for epidermal stem cells.” Science 309, no. 5736 (August 5, 2005): 890-1.

21 Student Led Discussion Presentation: C. elegans Ceol, C., and H. R. Horvitz. “A new class of C. elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of Ras signaling.” Developmental Cell 6 (2004): 563-576.

Fay D. S., and M. Han. “The synthetic multivulval genes of C. elegans: functional redundancy, Ras-antagonism, and cell fate determination.” Genesis 26, no. 4 (April 2000): 279-84.

22 Cloning and Epigenetics - Prof. Hazel Sive  
23 Student Led Discussion Presentation: Epigenesis and Cloning Gurdon J. B., J. A. Byrne, and S. Simonsson. “Nuclear reprogramming and stem cell creation.” Proc Natl Acad Sci U.S.A. 100 (Suppl 1) (September 30, 2003): 11819-22. (Epub August 14, 2003)

Nolen, L. D., S. Gao, Z. Han, M. R. Mann, Chung Y. Gie, A. P. Otte, M. S. Bartolomei, and K. E. Latham. “X chromosome reactivation and regulation in cloned embryos.” Dev Biol 279, no. 2 (March 15, 2005): 525-40.

Morgan H. D., F. Santos, K. Green, W. Dean, and W. Reik. “Epigenetic reprogramming in mammals.” Hum Mol Genet 14, spec no. 1 (April 15, 2005): R47-58.

24 Student Led Discussion Presentation: Human Development Vogelstein, B., B. Alberts, and K. Shine. “Genetics. Please don’t call it cloning!” Science 295, no. 5558 (February 15, 2005): 1237.

Birmingham, Alabama. “Assisted Reproductive Technologies: A Guide for Patients.” American Society for Reproductive Medicine, Patient Information Series. Copyright 2003.

Marx, J. “Neurodegeneration. Huntington’s research points to possible new therapies.” Science 310, no. 5745 (October 7, 2005): 43-5.

Wusthoff, C. “MSJAMA. The dilemma of confidentiality in Huntington disease.” JAMA 290, no. 9 (September 3, 2003): 1219-20.

Sermon, K., A. Van Steirteghem, and I. Lancet Liebaers. “Preimplantation genetic diagnosis.” 363, no. 9421 (May 15, 2004): 1633-41.

Holm, S. “Going to the roots of the stem cell controversy.” Bioethics 16, no. 6 (November 2002): 493-507.

Principles of Development Handout - Terms to Know. (PDF)

Recommended Texts

Wolpert, Lewis. Principles of Development. 2nd ed. New York, NY: Oxford University Press, 2001. ISBN: 9780198792918.

Kalthoff, Klaus. Analysis of Biological Development. 2nd ed. Boston, MA: McGraw-Hill, 2001. ISBN: 0071180788.

Slack, J. M. W. Essential Developmental Biology. Malden, MA: Blackwell Science, 2001. ISBN: 9780632052332.

Bier, Ethan. The Coiled Spring: How Life Begins. Plainview, NY: Cold Spring Harbor Laboratory Press, 2000. ISBN 9780879695637.

Gerhart, John, and Marc Kirschner. Cells, Embryos, and Evolution: Toward a Cellular and Developmental Understanding of Phenotypic Variation and Evolutionary Adaptability. Malden, MA: Blackwell Science, 1997. ISBN: 9780865425743.

Russo, V. E. A., et al., eds. Development: Genetics, Epigenetics, and Environmental Regulation. New York, NY: Springer, 1999. ISBN: 9783540627548.

Arias, Alfonso Martinez, and Alison Stewart. Molecular Principles of Animal Development. New York, NY: Oxford University Press, 2002. ISBN: 9780198792840.

Rao, Mahendra S., and Marcus Jacobson, eds. Developmental Neurobiology. 4th ed. New York, NY: Springer-Verlag, 2005. ISBN: 9780306483301.

Course Info

As Taught In
Fall 2005
Learning Resource Types
Presentation Assignments
Written Assignments