7.27 | Spring 2006 | Undergraduate

Principles of Human Disease


Course Meeting Times

Lectures: 2 sessions / week, 1.5 hours / session


This course covers current understanding of, and modern approaches to, human disease, emphasizing the molecular and cellular basis of both genetic disease and cancer.

Specific topics include:

  • The Genetics of Simple and Complex Traits;
  • Karyotypic Analysis and Positional Cloning;
  • Genetic Diagnosis;
  • The Roles of Oncogenes and Tumor Suppressors in Tumor Initiation, Progression and Treatment;
  • The Interaction between Genetics and Environment;
  • Animal Models of Human Disease and Cancer;
  • Infectious Diseases including Bacterial, Viral and Eukaryotic Pathogens; and
  • Disease Treatment Strategies including Drug Development and Gene Therapy.


Five Problem Sets 10%
Two Paper Assignments 10%
Two In-class Exams 50%
Non-comprehensive Final Exam 30%

Course Info

As Taught In
Spring 2006
Learning Resource Types
Problem Sets
Written Assignments