See the Lecture Summaries to read about the discussions that took place around each week’s readings.
| Week | Topics | Readings |
|---|---|---|
| 1 | Welcome to the “Battlefield”—Introduction to Host-Pathogen Interactions and How to Effectively Read Journal Articles | [No Readings] |
| 2 | Identify the Enemy—Koch’s Postulates |
Marshall B.J., Armstrong J.A., McGechie D.B., et al. Attempt to fulfill Koch’s postulates for pyloric Campylobacter. Med. J. Aust. 1985. 142 (8) : 436–9. doi: 10.5694/j.1326-5377.1985.tb113443.x. PMID: 3982345. Ohnishi N., Yuasa H., Tanaka S., et al. Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse. Proc. Natl. Acad. Sci. U S A. 2008. 105 (3) : 1003–8. doi: 10.1073/pnas.0711183105. Epub 2008 Jan 11. PMID: 18192401; PMCID: PMC2242726. |
| 3 | The World’s Deadliest Infectious Disease—Tuberculosis |
Riley R.L., Mills C.C., Nyka W., et al. Aerial dissemination of pulmonary tuberculosis. A two-year study of contagion in a tuberculosis ward. 1959. Am. J. Epidemiol. 1995, 142 (1) : 3–14. doi: 10.1093/oxfordjournals.aje.a117542. PMID: 7785671. Baranowski C., Welsh M.A., Sham L.T., et al. Maturing Mycobacterium smegmatis peptidoglycan requires non-canonical crosslinks to maintain shape. Elife. 2018. 7:e37516. doi: 10.7554/eLife.37516. PMID: 30324906; PMCID: PMC6231781. |
| 4 | On the Front Lines—How Bacteria Can Stake Their Claim on the Battlefield |
Zhou G., Mo W.J., Sebbel P., et al. Uroplakin Ia is the urothelial receptor for uropathogenic Escherichia coli: evidence from in vitro FimH binding. J. Cell. Sci. 2001. 114 (Pt 22) : 4095–103. doi: 10.1242/jcs.114.22.4095. PMID: 11739641. Spaulding C.N., Klein R.D., Ruer S., et al. Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist. Nature. 2017. 546 (7659) : 528–532. doi: 10.1038/nature22972. Epub 2017 Jun 14. PMID: 28614296; PMCID: PMC5654549. |
| 5 | Not All Microbes Are Bad —Field Trip Preparation |
Kehe, J., Ortiz, A., Kulesa, A., et al. Positive interactions are common among culturable bacteria. Sci. Adv., 7 (45), eabi7159.PMCID: PMC8570599, DOI: 10.1126/sciadv.abi7159 Ackerman, C.M., Myhrvold, C., Thakku, S.G., et al. Massively multiplexed nucleic acid detection with Cas13. Nature, 582 (7811), 277–282. PMCID: PMC7332423, DOI: 10.1038/s41586-020-2279-8 |
| 6 |
Field Trip!!! Concerto Biosciences Written Assignment Due |
[No Readings] |
| 7 | Preprint Week—and the Mysterious Hepatitis Outbreak |
Morfopoulou S., Buddle S., Torres Montaguth O., et al. Genomic investigations of acute hepatitis of unknown aetiology in children. Nature. 2023. 617 : 564–73. doi: 10.1038/s41586-023-06003-w. Ho A., Orton R., Tayler R., et al. Adeno-associated virus 2 infection in children with non-A-E hepatitis. Nature. 2023. 617 : 555-63. doi: 10.1038/s41586-023-05948-2. |
| 8 | Illness Is Sweeping through the Ranks—Norovirus (Winter Vomiting Bug) |
Orchard R.C., Wilen C.B., Doench J.G., et al. Discovery of a proteinaceous cellular receptor for a norovirus. Science. 2016. 353 (6302) : 933–6. doi: 10.1126/science.aaf1220. Epub 2016 Aug 18. PMID: 27540007; PMCID: PMC5484048. Graziano V.R., Walker F.C., Kennedy E.A., et al. CD300lf is the primary physiologic receptor of murine norovirus but not human norovirus. PLoS Pathog. 2020. 16 (4) : e1008242. doi: 10.1371/journal.ppat.1008242. PMID: 32251490; PMCID: PMC7162533. |
| 9 | Biological Sex, Pregnancy, and Infectious Diseases—Malaria |
Salanti A., Dahlbäck M., Turner L., et al. Evidence for the involvement of VAR2CSA in pregnancy-associated malaria. J. Exp. Med. 2004. 200 (9) : 1197–203. doi: 10.1084/jem.20041579. PMID: 15520249; PMCID: PMC2211857. Keen J., Serghides L., Ayi K., et al. HIV impairs opsonic phagocytic clearance of pregnancy-associated malaria parasites. PLoS Med. 2007. 4 (5) : e181. doi: 10.1371/journal.pmed.0040181. PMID: 17535103; PMCID: PMC1880852. |
| 10 |
Friendly Fire–How the Immune System Can Go Awry, and a Tick Bite Can Lead to Allergic Reactions to Meat Final Presentation Topic Due |
Chung C.H., Mirakhur B., Chan E., et al. Cetuximab-induced anaphylaxis and IgE specific for galactose-alpha-1,3-galactose. N. Engl. J. Med. 2008. 358 (11) : 1109–17. doi: 10.1056/NEJMoa074943. PMID: 18337601; PMCID: PMC2361129. Commins S.P., Satinover S.M., Hosen J., et al. Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose-alpha-1,3-galactose. J. Allergy Clin. Immunol. 2009. 123 (2) : 426–33. doi: 10.1016/j.jaci.2008.10.052. Epub 2008 Dec 13. PMID: 19070355; PMCID: PMC3324851. |
| 11 | A Battle You Have Been a Part of—The Global Fight Against COVID-19 |
Zazhytska M., Kodra A., Hoagland D.A., et al. Non-cell-autonomous disruption of nuclear architecture as a potential cause of COVID-19-induced anosmia. Cell. 2022. 185 (6) : 1052–1064.e12. doi: 10.1016/j.cell.2022.01.024. Epub 2022 Feb 2. PMID: 35180380; PMCID: PMC8808699. Bastard P., Rosen L.B., Zhang Q., et al. Autoantibodies against type I IFNs in patients with life-threatening COVID-19. Science. 2020. 370 (6515) : eabd4585. doi: 10.1126/science.abd4585. Epub 2020 Sep 24. PMID: 32972996; PMCID: PMC7857397. |
| 12 | What is Your Favorite (or Least Favorite) Microbe? | [No Readings] |
| 13 | The Final Battle—Oral Presentations | [No Readings] |
