7.51 | Fall 2001 | Graduate
Graduate Biochemistry

Calendar

Lec # Topics Instructors
1 Reaction models; simple kinetics & equilibria Bob Sauer
2 Analyzing kinetic & equilibria experiments  
3 Free energy, entropy, enthalpy & cycles  
4 Forces, hydrophobic effect, chelate effect  
5 Molecular structure and dynamics  
6 Physical properties of proteins and nucleic acids Tania Baker
7 Principles and practice of protein purification  
8 Principles and practice of protein purification (cont.)  
9 EXAM 1  
10 Domain & subunit organization; molecular weight determination Tania Baker
11 Macromolecular interactions: specificity, affinity and energetics  
12 Macromolecular interactions: specificity, affinity and energetics (cont.)  
13 Enzyme catalysis: kinetics Frank Solomon
14 Mechanism of enzyme catalyzed reactions  
15 inhibition and intermediates  
16 Mechanism of enzyme catalyzed reactions: chemistry  
17 Mechanism of enzyme catalyzed reactions: partitioning & exchange  
18 Mechanism of enzyme catalyzed reactions: binding energy  
19 Specificity of catalysis: energetics and consequences  
20 Specificity of catalysis: energetics and consequences (cont.)  
21 EXAM 2  
22 Coupled vectorial processes: making ATP Frank Solomon
23 Coupled vectorial processes: pumps  
24 Coupled vectorial processes: OxPhos, morphology to enzymology  
25 Coupled vectorial processes: processivity  
26 Coupled vectorial processes: Motors; Polymers – origins & consequences of structural & thermodynamic polarity  
27 Coupled vectorial processes: motors; structural & thermodynamic polarity  
28 Coupled vectorial processes: protein folding  
29 Review Session  
30 FINAL EXAM  
Course Info
Departments
As Taught In
Fall 2001
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Learning Resource Types
notes Lecture Notes