Systems Biology

Calendar

LEC #	TOPICS	KEY DATES
Part I: Systems Microbiology - ‘The Cell as a Well-stirred Bioreactor’
1	Introduction Michaelis-Menten Kinetics
2	Equilibrium Binding Cooperativity
3	Lambda Phage Multistability
4	Multistability (cont.)
5	Synthetic Genetic Switches
6	Stability Analysis
7	Introduction E. coli Chemotaxis
8	Fine-tuned versus Robust Chemotaxis Models	Problem set 1 due
9	Wrapping up Chemotaxis
10	Genetic Oscillators
11	Genetic Oscillators (cont.)
12	Stochastic Chemical Kinetics	Problem set 2 due
13	Stochastic Chemical Kinetics (cont.)
Part II: Cell Systems Biology - ‘The Importance of Diffusion and Gradients for Cellular Regulation’
14	Introduction Cell Systems Biology Fick’s Laws
15	Local Excitation Global Inhibition Theory
16	Local Excitation (cont.) Global Inhibition Theory (cont.)	Problem set 3 due
17	Rapid Pole-to-pole Oscillations in E. coli
18	Rapid Pole-to-pole Oscillations in E. coli (cont.)
19	Models for Eukaryotic Gradient Sensing	Problem set 4 due
20	Models for Eukaryotic Gradient Sensing (cont.)
21	Modeling Cytoskeleton Dynamics
22	Modeling Cytoskeleton Dynamics (cont.)	Problem set 5 due
Part III: Developmental Systems Biology - ‘Building an Organism Starting From a Single Cell’
23	Quorum Sensing
24	Final Problem Set Question Hour
25	Drosophila Development	Take home final due