9.10 | Spring 2006 | Undergraduate

Cognitive Neuroscience


1 Introduction to cognitive neuroscience


Neuroanatomy demonstration, wet lab

Nolte, 2002. Chapter 3.

Neuroimaging methods in cognitive neuroscience

Walsh, Vincent, and Alan Cowey. “Transcranial Magnetic Stimulation and Cognitive Neuroscience.” Nature Reviews Neuroscience 1 (2000): 73-79.

Matthews, P. M., and P. Jezzard. “Functional Magnetic Resonance Imaging.” J Neurol Neurosurg Psychiatry 75 (2004): 6-12.

Le Bihan, Denis. “Looking into the Functional Architecture of the Brain with Diffusion MRI.” Nature Reviews Neuroscience 4 (2003): 469-480.

Fox, Michael D., Abraham Z. Snyder, Jeffrey M. Zacks, and Marcus E. Raichle. “Coherent Spontaneous Activity Accounts for Trial-to-trial Variability in Human Evoked Brain Responses.” Nature Neuroscience 9 (2006): 23-25.

4 A critical eye on fMRI

Thomason, Moriah E., Brittany E. Burrows, John D. E. Gabrieli, and Gary H. Glover. “Breath Holding Reveals Differences in fMRI BOLD Signal in Children and Adults.” NeuroImage 25 (2005): 824-837.

Buckner, Randy I., et al. “Functional Brain Imaging of Young, Nondemented, and Demented Older Adults.” Journal of Cognitive Neuroscience 12 (2000): 24-34.

Heeger, David J., and David Ress. “What does fMRI tell us About Neuronal Activity?” Nature Reviews Neuroscience 3 (2002): 142-151.

Schlaggar, Bradley L., et al. “Functional Neuroanatomical Differences Between Adults and School-Age Children in the Processing of Single Words.” Science 296 (2002): 1476-1479.

5 Object recognition

Grill-Spector, Kalanit, and Nancy Kanwisher. “Visual Recognition: As Soon As You Know It Is There, You Know What It Is.” Psychological Science 16 (2005): 152-160.

Rodman, H., L. Pessoa, and L. Ungerleider. “Visual Perception of Objects.” In: L. Squire, F. Bloom, S. McConnell, et al. (eds.) Fundamental Neuroscience. 2nd ed. Burlington, MA: Academic Press, pp. 1201-1228.

Sacks, Oliver. The Man Who Mistook His Wife for a Hat. New York, NY: Summit Books, 1985. Chapter 1. ISBN: 9780671554712.

6 Functional specialization of high-level vision

Haxby, James V., et al. “Distributed and Overlapping Representations of Faces and Objects in Ventral Temporal Cortex.” Science 293 (2001): 2425-2430.

Kourtzi, Zoe, and Nancy Kanwisher. “Representation of Perceived Object Shape by the Human Lateral Occipital Complex.” Science 293 (2001): 1506-1509.

Levy, Ifat, Uri Hasson, Galia Avidan, Talma Hendler, and Rafael Malach. “Center-Periphery Organization of Human Object Areas.” Nature Neuroscience 4 (2001): 533-539.

Tsao, Doris Y., Winrich A. Freiwald, Roger B. H. Tootell, and Margaret S. Livingstone. “A Cortical Region Consisting Entirely of Face-Selective Cells.” Science 311 (2006): 670-674.

7 Attention

Bichot, Narcisse P., Andrew F. Rossi, and Robert Desimone. “Parallel and Serial Neural Mechanisms for Visual Search in Macaque Area V4.” Science 308 (2005): 529-534.

Desimone, Robert, and John Duncan. “Neural Mechanisms of Selective Visual Attention.” Ann Rev Neurosci 18 (1995): 193-222.

Corbetta, Maurizio, and Gordon L. Shulman. “Control of Goal-Directed and Stimulus-Driven Attention in the Brain.” Nature Reviews Neuroscience 3 (2002): 201-215.

Moore, Tirin, and Katherine M. Armstrong. “Selective Gating of Visual Signals by Microstimulation of Frontal Cortex.” Nature 421 (2003): 370-373.

8 Attention and neglect

Hilgetag, Claus C., Hugo Theoret, and Alvaro Pascual-Leone. “Enhanced Visual Spatial Attention Ipsilateral to rTMS-induced ‘Virtual Lesions’ of Human Parietal Cortex.” Nature Neuroscience 4 (2001): 953-957.

Pessoa, Luiz, Sabine Kastner, and Leslie G. Ungerleider. “Neuroimaging Studies of Attention: from Modulation of Sensory Processing to Top-Down Control.” J Neuroscience 23 (2003): 3990-3998.

Vuilleumier, Patrik, Sophie Schwartz, Karen Clarke, Masud Husain, and Jon Driver. “Testing Memory for Unseen Visual Stimuli in Patients with Extinction and Spatial Neglect.” Journal of Cognitive Neuroscience 14 (2002): 875-886.

Mesulam, M.-Marsel. “Spatial Attention and Neglect: Parietal, Frontal and Cingulate Contributions to the Mental representation and Attentional Targeting of Salient Extrapersonal Events.” Phil Trans R Soc Lond B 354 (1999): 1325-1346.

9 Mental imagery

Kosslyn, Stephen M., Giorgio Ganis, and William L. Thompson. “Neural Foundations of Imagery.” Nature Reviews Neuroscience 2 (2001): 635-642.

Behrmann, Marlene. “The Mind’s Eye Mapped Onto the Brain’s Matter.” Current Directions in Psychological Science 9 (2000): 50-54.

Bunzeck, Nico, et al. “Scanning Silence: Mental Imagery of Complex Sounds.” NeuroImage 26 (2005): 1119-1127.

Sack, A. T., J. A. Camprodon, A. Pascual-Leone, and R. Goebel. “The Dynamics of Interhemispheric Compensatory Processes in Mental Imagery.” Science 308 (2005): 702-704.

10 Navigation

Janzen, Gabriele, and Miranda van Turennout. “Selective Neural Representation of Objects Relevant for Navigation.” Nature Neuroscience 7 (2004): 673-677.

Burgess, Neil, Eleanor A. Maguire, and John O’Keefe. “The Human Hippocampus and Spatial and Episodic Memory.” Neuron 35 (2002): 625-641.

Wolbers, Thomas, and Christian Buchel. “Dissociable Retrosplenial and Hippocampal Contributions to Successful Formation of Survey Representations.” J Neuroscience 25 (2005): 3333-3340.

Voermans, Nicol C., et al. “Interaction between the Human Hippocampus and the Caudate Nucleus during Route Recognition.” Neuron 43 (2004): 427-435.

11 Synesthesia

Hubbard, Edward M., et al. “Individual Differences among Grapheme-Color Synesthetes: Brain-Behavior Correlations.” Neuron 45 (2005): 975-985.

Kadosh, Roi Cohen, et al. “When Blue is Larger than Red: Colors Influence Numerical Cognition in Synesthesia.” Journal of Cognitive Neuroscience 17 (2005): 1766-1773.

Knoch, Daria, Lorena R. R. Gianotti, Christine Mohr, and Peter Brugger. “Synesthesia: When Colors Count.” Cognitive Brain Research 25 (2005): 372-374.

Weiss, Peter H., Karl Zilles, and Gereon R. Fink. “When Visual Perception Causes Feeling: Enhanced Cross-Modal processing in Grapheme-Color Synesthesia.” NeuroImage 28 (2005): 859-868.

12 Novelty

Strange, Bryan A., et al. “Dissociating Intentional Learning from Relative Novelty Responses in the Medial Temporal Lobe.” NeuroImage 25 (2005): 51-62.

Yamaguchi, Shuhei, Laura A. Hale, Mark D’Esposito, and Robert T. Knight. “Rapid Prefrontal-Hippocampal Habituation to Novel Events.” J Neuroscience 24 (2004): 5356-5363.

Linden, David E. “The P300: Where in the Brain Is It Produced and What Does It Tell Us?” The Neuroscientist 11 (2005): 563-576.

Kohler, Stefan, Stacey Danckert, Joseph S. Gati, and Ravi S. Menon. “Novel Responses to Relational and Non-Relational Information in the Hippocampus and the Parahippocampal Region: A comparison Based on Event-Related fMRI.” Hippocampus 15 (2005): 763-774.

Mid-term test

13 Frontal lobe functions

Mitchell, Jason P., Mahzarin R. Banaji, and C. Neil Macrae. “General and Specific Contributions of the Medial Prefrontal Cortex to Knowledge about Mental States.” NeuroImage 28 (2005): 757-762.

Stuss, Donald T., and Brian Levine. “Adult Clinical Neuropsychology: Lessons from Studies of the Frontal Lobes.” Annu Rev Psychol 53 (2002): 401-433.

Huettel, Scott A., Peter B. Mack, and Gregory McCarthy. “Perceiving Patterns in Random Series: Dynamic Processing of Sequence in Prefrontal Cortex.” Nature Neuroscience 5 (2002): 485-490.

Gagno, Danny, Tomas Paus, et al. “Transcranial Magnetic Stimulation of Frontal Oculomotor Regions during Smooth Pursuit.” J Neuroscience 26 (2006): 458-466.

14 Working memory and control processes

Simons, Jon S., Adrian M. Owen, Paul C. Fletcher, and Paul W. Burgess. “Anterior Prefrontal Cortex and the Recollection of Contextual Information.” Neuropsychologia 43 (2005): 1774-1783.

Buchsbaum, Bradley R., Rosanna K. Olsen, Paul Koch, and Karen Faith Berman. “Human Dorsal and Ventral Auditory Streams Subserve Rehearsal-Based and Echoic Processes during Verbal Working Memory.” Neuron 48 (2005): 687-697.

Miller, Earl K., and Jonathan D. Cohen. “An Integrative Theory of Prefrontal Cortex Function.” Annu Rev Neurosci 24 (2001): 167-202.

Badre, David, and Anthony D. Wagner. “Semantic Retrieval, Mnemoic Control, and Prefrontal Cortex.” Behavioral and Cognitive Neuroscience Reviews 1 (2002): 206-218.

15 Reward

O’Doherty, John P., Tony W. Buchanan, Ben Seymour, and Raymond J. Dolan. “Predictive Neural Coding of Reward Preference Involves Dissociable Responses in Human Ventral Midbrain and Ventral Striatum.” Neuron 49 (2006): 157-166.

Schultz, Wolfram. “Behavioral Theories and the Neurophysiology of Reward.” Annu Rev Psychol 57 (2006): 87-115.

Galvan, Adriana, et al. “The Role of Ventral Frontostriatal Circuitry in Reward-Based Learning in Humans.” J Neuroscience 25 (2005): 8650-8656.

Kringelbach, Morten L. “The Human Orbitofrontal Cortex: Linking Reward to Hedonic Experience.” Nature Reviews Neuroscience 6 (2005): 691-702.


Parkinson’s disease

Case presentation

Singleton, A. B., et al. “α-Synuclein Locus Triplication Causes Parkinson’s Disease.” Science 302 (2003): 841.

Aarsland, Dag, et al. “Prevalence and Characteristics of Dementia in Parkinson Disease.” Arch Neurol 60 (2003): 387-392.

Emre, Murat, et al. “Rivastigmine for Dementia Associated with Parkinson’s Disease.” N Engl J Med 351 (2004): 2509-2518.

Locascio, Joseph J., Suzanne Corkin, and John H. Growdon. “Relation Between Clinical Characteristics of Parkinson’s Disease and Cognitive Decline.” Journal of Clinical and Experimental Neuropsychology 25 (2003): 94-109.

17 Audition and music

Mukamel, Roy, et al. “Coupling Between Neuronal Firing, Field Potentials, and fMRI in Human Auditory Cortex.” Science 309 (2005): 951-954.

Gaab, Nadine, Christian Gaser, and Gottfried Schlaug. “Improvement-Related Functional Plasticity following Pitch Memory Training.” NeuroImage 31 (2006): 255-263.

Koelsch, Stefan, and Walter A. Siebel. “Towards a Neural Basis of Music Perception.” Trends in Cognitive Sciences 9 (2005): 578-584.

Zatorre, Robert J., Pascal Belin, and Virginia B. Penhune. “Structure and Function of Auditory Cortex: Music and Speech.” Trends in Cognitive Sciences 6 (2002): 37-46.

18 Amusia

Di Pietro, Marie, Marina Laganaro, Beatrice Leemann, and Armin Schnider. “Receptive Amusia: Temporal Auditory Processing Deficit in a Professional Musician Following a Left Temporo-Parietal Lesion.” Neuropsychologia 42 (2004): 868-877.

Peretz, Isabelle, et al. “Congenital Amusia: A Disorder of Fine-Grained Pitch Discrimination.” Neuron 33 (2002): 185-191.

Peretz, Isabelle, and Krista L. Hyde. “What is Specific to Music Processing? Insights from Congenital Amusia.” Trends in Cognitive Sciences 7 (2003): 362-367.

Hyde, Krista L., and Isabelle Peretz. “Brains that are Out of Tune But in Time.” Psychological Science 15 (2004): 356-360.

19 Sex steroids and cognition

Janowsky, Jeri S. “Thinking with Your Gonads: Testosterone and Cognition.” Trends in Cognitive Sciences 10 (2006): 77-82.

Spelke, Elizabeth S. “Sex Differences in Intrinsic Aptitude for Mathematics and Science?” American Psychologist 60 (2005): 950-958.

Azim, Eiman, et al. “Sex Differences in Brain Activation Elicited by Humor.” PNAS 102 (2005): 16496-16501.

Hamann, Stephan, Rebecca A. Herman, Carla L. Nolan, and Kim Wallen. “Men and Women Differ in Amygdala Response to Visual Sexual Stimuli.” Nature Neuroscience 7 (2004): 411-416.

20 Plasticity in the adult brain

Poldrack, Russell A. “Imaging Brain Plasticity: Conceptual and Methodological Issues - a Theoretical Review.” NeuroImage 12 (2000): 1-13.

Merabet, Lotfi B., et al. “What Blindness Can Tell Us about Seeing Again: Merging Neuroplasticity and Neuroprostheses.” Nature Reviews Neuroscience 6 (2005): 71-77.

Amedi, Amir, et al. “Transcranial Magnetic Stimulation of the Occipital Pole Interferes with Verbal Processing in Blind Subjects.” Nature Neuroscience 7 (2004): 1266-1270.

Colcombe, Stanley J. “Cardiovascular Fitness, Cortical Plasticity, and Aging.” PNAS 101 (2004): 3316-3321.

21 Anomia and category-specific naming disorders

Seidenberg, Michael, Elizabeth Geary, and Bruce Hermann. “Investigating Temporal Lobe Contribution to Confrontation Naming using MRI Quantitative Volumetrics.” Journal of the International Neuropsychological Society 11 (2005): 358-366.

Martin, Alex, and Linda L. Chao. “Semantic Memory and the Brain: Structure and Processes.” Current Opinion in Neurobiology 11 (2001): 194-201.

Farah, Martha J., and Carol Rabinowitz. “Genetic and Environmental Influences on the Organisation of Semantic Memory in the Brain: Is ‘Living Things’ an Innate Category?” Cognitive Neuropsychology 20 (2003): 401-408.

Caramazza, Alfonso, and Bradford Z. Mahon. “The Organization of Conceptual Knowledge: the Evidence from Category-Specific Semantic Deficits.” Trends in Cognitive Sciences 7 (2003): 354-361.

22 Effects of sleep on memory

Stickgold, Robert, et al. “Replaying the Game: Hypnagogic Images in Normals and Amnesics.” Science 290 (2000): 350-353.

Takashima, A., et al. “Declarative Memory Consolidation in Humans: A Prospective Functional Magnetic Resonance Imaging Study.” PNAS 103 (2006): 756-761.

Walker, Matthew P., and Robert Stickgold. “Sleep, Memory, and Plasticity.” Annu Rev Psychol 57 (2006): 139-166.


Mild cognitive impairment and alzheimer’s disease

Case presentation

Klunk, William E., et al. “Imaging Brain Amyloid in Alzheimer’s Disease with Pittsburgh Compound-B.” Ann Neurol 55 (2004): 306-319.

Locascio, Joseph J., John H. Growdon, and Suzanne Corkin. “Cognitive Test Performance in Detecting, Staging and Tracking Alzheimer’s Disease.” Archives of Neurology 52 (1995): 1087-1099.

Petersen, Ronald C., et al. “Mild cognitive impairment: Clinical Characterization and Outcome.” Archives of Neurology 56 (1999): 303-308.

SantaCruz, K., et al. “Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function.” Science 309 (2005): 476-481.

24 Cognition in alzheimer’s disease

Buckner, Randy L., et al. “Molecular, Structural, and Functional Characterization of Alzheimer’s Disease: Evidence for a Relationship Between Default Activity, Amyloid, and Memory.” J Neuroscience 25 (2005): 7709-7717.

Scheff, Stephen W., Douglas A. Price, Frederick A. Schmitt, and Elliot J. Mufson. “Hippocampal Synaptic Loss in Early Alzheimer’s Disease and Mild Cognitive Impairment.” Neurobiol Aging 27 (2006): 1372-1384.

Mitchell, Jason P., Alison L. Sullivan, Daniel L. Schacter, Andrew E. Budson. “Misattribution Errors in Alzheimer’s Disease: The Illusory Truth Effect.” Neuropsychology 20 (2006): 185-192.


Developmental cognitive neuroscience

Pascalis, Olivier, Michelle de Haan, and Charles A. Nelson. “Is Face Processing Species-Specific During the First year of Life?” Science 296 (2002): 1321-1323.

Pascalis, O., et al. “Plasticity of Face Processing in Infancy.” PNAS 102 (2005): 5297-5300.

Nelson, Charles A., Kathleen M. Thomas, and Michelle de Haan. Neuroscience of Cognitive Development: The Role of Experience and the Developing Brain. Hoboken, NJ: John Wiley & Sons, 2006. Chapter 1. ISBN: 9780471745860.

Final examination

Course Info

As Taught In
Spring 2006
Learning Resource Types
Written Assignments