9.322J | Fall 2005 | Graduate

Genetic Neurobiology




Introduction to Course



Bacterial Chemoreception



Student Presentations

Berg, H. C. “Bacterial microprocessing.” Cold Spring Harb Symp Quant Biol 55 (1990): 539-45.

Adler, J. “Chemoreceptors in bacteria.” Science 166, no. 913 (December 26, 1969): 1588-97.

Oosawa, K., J. F. Hess, and M. I. Simon. “Mutants defective in bacterial chemotaxis show modified protein phosphorylation.” Cell 53, no. 1 (April 8, 1988): 89-96.


Bacterial and Paramecium Motility

Zhang, Y., H. Lu, and C. I. Bargmann. “Pathogenic bacteria induce aversive olfactory learning in Caenorhabditis elegans.” Nature 438, no. 7065 (November 10, 2005): 179-84.


Student Presentations

Berg, H. C. “The rotary motor of bacterial flagella.” Annu Rev Biochem 72 (2003): 19-54. Epub December 11, 2002.

Blair, D. F., and H. C. Berg. “Restoration of torque in defective flagellar motors.” Science 242, no. 4886 (December 23, 1988): 1678-81.

Meister, M., G. Glowe, and H. C. Berg. “The proton flux through the bacterial flagellar motor.” Cell 49, no. 5 (June 5, 1987): 643-50.


Neurogenomics: Genome Sequencing and the Nervous System

Carpenter, A. E., and D. M. Sabatini. “Systematic genome-wide screens of gene function.” Nat Rev Genet 5, no. 1 (January 2004): 11-22.

Palladino, M. J., L. P. Keegan, M. A. O’Connell, and R. A. Reenan. “A-to-I pre-mRNA editing in Drosophila is primarily involved in adult nervous system function and integrity.” Cell 102, no. 4 (August 18, 2000): 437-49.

Hoopengardner, B., T. Bhalla, C. Staber, and R. Reenan. “Nervous system targets of RNA editing identified by comparative genomics.” Science 301, no. 5634 (August 8, 2003): 832-6.


Student Presentations



Development of the Nervous System



Student Presentations



Genetic Analysis of Axonal Pathfinding

Student Presentations



Genetic Analysis of Membrane Excitability

Student Presentations



Neurodevelopment and Function in the Mouse

Kano, M., K. Hashimoto, C. Chen, A. Abeliovich, A. Aiba, H. Kurihara, M. Watanabe, Y. Inoue, and S. Tonegawa. “Impaired synapse elimination during cerebellar development in PKC gamma mutant mice.” Cell 83, no. 7 (December 29, 1995): 1223-31.

Caviness, V. S. “Reeler mutant mouse: a genetic experiment in developing mammalian cortex.” Soc Neurosci Symp 2 (1977): 27-46.


Student Presentations



Neurotransmitter Release at Nerve Terminals



Student Presentations



Genetic Analysis of Sensory Perception



Student Presentations



Higher Brain Function in Drosophila: Learning and Circadian Rhythms

Konopka, R. J., and S. Benzer. “Clock mutants of Drosophila melanogaster.” Proc Natl Acad Sci U.S.A. 68, no. 9 (September, 1971): 2112-6.

Waddell, S., J. D. Armstrong, T. Kitamoto, K. Kaiser, and W. G. Quinn. “The amnesiac gene product is expressed in two neurons in the Drosophila brain that are critical for memory.” Cell 103, no. 5 (November 22, 2000): 805-13.


Student Presentations



Synapse Formation in Vertebrates and Invertebrates

Student Presentations



Genetic Analysis of Learning and Memory in Mice



Student Presentations

Nakazawa, K., M. C. Quirk, R. A. Chitwood, M. Watanabe, M. F. Yeckel, L. D. Sun, A. Kato, C. A. Carr, D. Johnston, M. A. Wilson, and S. Tonegawa. “Requirement for hippocampal CA3 NMDA receptors in associative memory recall.” Science 297, no. 5579 (July 12, 2002): 211-8. Epub May 30, 2002.


Neurogenetics in Humans: Memory and Disease



Student Presentations

Millar, J. K., B. S. Pickard, S. Mackie, R. James, S. Christie, S. R. Buchanan, M. P. Malloy, J. E. Chubb, E. Huston, G. S. Baillie, P. A. Thomson, E. V. Hill, N. J. Brandon, J. C. Rain, L. M. Camargo, P. J. Whiting, M. D. Houslay, D. H. Blackwood, W. J. Muir, and D. J. Porteous. “DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling.” Science 310, no. 5751 (November 18, 2005): 1187-91.

Course Info

As Taught In
Fall 2005
Learning Resource Types
Written Assignments
Presentation Assignments