Macroepidemiology (BE.102)

Calendar

LEC #	TOPICS	KEY DATES
1	Introduction: Dimensions of information available to define the unknown causes of common diseases
2	Public health records and estimation of age-specific risk
3	Effects of changes in diagnosis, prevention and therapy on historical mortality rates Sources of differences in reported incidence and mortality	PS 1 due
4	Mathematical models derived from histopathological observations and age-specific mortality/incidence data Examples: lung and colorectal cancers
5	Initiation
6	Promotion and Progression	Term paper chapter 1 due
7	Multiparametric Analysis of Colon Cancer
8	Multiparametric Analysis of Lung Cancer	PS 3 due
9	Role of Gender
10	Sub-populations at Risk
11	National Risk and Community Risk
12	Familial Risk Expectations
13	Familial Risk Observations	Term paper chapter 2 due
14	Population Genetics
15	Population Genetics (cont.)
16	The search for genes carrying mutations conferring risk for common diseases
17	The search for genes carrying mutations conferring risk for common diseases (cont.)
18	The search for genes carrying mutations conferring risk for common diseases (cont.)	Term paper chapter 3 due
19	The search for genes carrying mutations conferring risk for common diseases (cont.)
20	The search for genes in which mutations of initiation (and promotion, if any) occur in common human cancers
21	The origins of somatic and inherited mutations in humans
22	The origins of somatic and inherited mutations in humans (cont.)
23	Hypotheses that need testing	Term paper chapter 4 due
24	Evolution, embryogenesis and carcinogenesis (Guest lecturer: Dr. Elena V. Gostjeva) Putting it together: Gostjeva-Thilly cascade model for risk and genesis of common clonal diseases
25-27	General discussion and student presentations	Final term paper due