20.110J | Fall 2005 | Undergraduate

Thermodynamics of Biomolecular Systems

Lecture Notes

MB = Prof. Moungi Bawendi
KHS = Prof. Kimberly Hamad-Schifferli
LGG = Prof. Linda G. Griffith

LEC # TOPICS LECTURERS
1 Introduction to Thermo; 0th Law; Temperature; Work; Heat (PDF) MB
2 State Functions, 1st Law, Paths (PDF) MB
3 Joule and Joule-Thompson; Heat Capacity (PDF) MB
4 Reversible and Irreversible Processes (PDF) MB
5 Thermochemistry (PDF) MB
6 2nd Law; Entropy (Boltzmann and Clausius) (PDF) MB
7 ΔS for Reversible and Irreversible Processes (PDF) MB
8 Equilibrium; Maxwell Relations; Free Energy (PDF) MB
9 Chemical Potential; Phase Equilibrium (PDF) MB
10 Chemical Equilibrium; Equilibrium Constant (PDF) MB
11 Standard States; Gibbs-Duhem (PDF) MB
12 ΔG0= -RTlnK; Example (PDF) MB
  Hour Exam 1  
13 Boltzmann Distribution (PDF) KHS
14 Thermo and Boltzmann Distribution (PDF) KHS
15 Occupation of States (PDF) KHS
16 Third Law (PDF) KHS
17 Phase Equilibria, Single Component (PDF) KHS
18 Phase Equilibria II; Clausius Clapeyron (PDF) KHS
19 Regular Solutions; Mixing Energy; Mean Fields KHS
20 Nonideal Solutions KHS
21 Solvation; Colligative Properties (PDF) LGG
  Hour Exam 2  
22 Osmotic Pressure and Phase Partitioning (PDF) LGG
23 Surface Tension (PDF) LGG
24 Polymer 1 - Freely Jointed Chain (PDF) LGG
25 Polymer 2 - Chain Conformation (PDF) LGG
26 Polymer 3 - Rubber Elasticity (PDF - 2.2 MB) LGG
27 Electrolyte Solutions (PDF) LGG
28 Electrolytes at Interfaces; Debye Length (PDF) LGG
29 Titration of Polyelectrolytes (PDF) LGG
30 Thermodynamics of DNA Hybridization (PDF - 1.5 MB) LGG
31 Cooperativity (PDF) KHS
  Hour Exam 3  
32 Cooperativity, Part 2 KHS
33 Cooperativity, Part 3 KHS
34 Driving Forces for Self-Assembly KHS
35 Special Topic (Coarse Grain/Monte Carlo Model)  
36 Course Review and Evaluations