Molecular Principles of Biomaterials

Calendar

LEC #	TOPICS	KEY DATES
1	Overview of Course, Orientation to Current Approaches and Types of Molecularly-designed Biomaterials Biodegradable Polymeric Solids Chemistry and Physical Chemistry of Hydrolysis Links between Materials Structure and Hydrolysis Mechanisms
2	Biodegradable Polymeric Solids (cont.) Factors Controlling Polymer Degradation Rates Theory of Solid Polymer Erosion Tailoring Degradable Polymer Structure and Composition	Problem set 1 out
3	Controlled Release Devices Types of Controlled Release Devices Degradable Materials in Controlled Release Devices Physical Chemistry Principles in Delivering Small Molecules vs. Proteins
4	Controlled Release Devices (cont.) Theory of Drug Release in Eroding Systems	Problem set 1 due Problem set 2 out
5	Case Studies in Complex Controlled Release Pulsatile Release from Programmed Eroding Systems Controlled Release Microchips Combining Drug Delivery with Tissue Engineering	Problem set 2 due Problem set 3 out
6	Hydrogels as Biomaterials Hydrogel Structure and Physical Chemistry Methods of Polymerization
7	Hydrogels as Biomaterials (cont.) Theory of Hydrogel Swelling Physical Hydrogels Ionic and Hydrogen Bonding in Gels Association of Amphiphilic Block Copolymers	Problem set 3 due Problem set 4 out
8	Hydrogels as Biomaterials (cont.) Polyelectrolyte Hydrogels Coacervates Polyelectrolyte Multi-layers
9	Hydrogels as Biomaterials (cont.) Theory of Polyelectrolyte Gel Swelling	Problem set 4 due Problem set 5 out
10	Hydrogels as Biomaterials (cont.) Applications of Hydrogels: Molecular Imprinting Applications of Hydrogels: Glucose-sensitive Drug Delivery Kinetics of Drug Diffusion Through Hydrogels
11	Engineering Biological Recognition of Biomaterials Biological Recognition in Vivo Protein-resistant and Cell-resistant Surfaces Engineering Recognition of Biomaterials: Adhesion and Migration	Problem set 5 due
	Exam 1
12	Engineering Biological Recognition of Biomaterials (cont.) Enzymatic Recognition of Biomaterials Cytokine Signaling from Biomaterials
13	Engineering Biological Recognition of Biomaterials (cont.) Mimicking Cell-cell Contacts with Surfaces	Problem set 6 out
14	Bioceramics and Biocomposites Introduction to Biological Approaches to Biomineralization Interfacial Biomineralization
15	Bioceramics and Biocomposites (cont.) Biological Control of Mineralization within Vesicles Biomimetic Syntheses: Microemulsion and Micellar Reactions Organic Templating of Inorganic Biomaterials: Natural and Synthetic Approaches	Problem set 6 due Problem set 7 out
16	Bioceramics and Biocomposites (cont.) Theory of Controlled Nucleation Bone Structure and Bone Biomimesis Biocomposites in Device Applications and Drug Delivery
17	Molecular Devices Molecular Switches via Proteins and ‘Smart’ Polymers Temperature, pH, and Light-sensitive Switches Molecular Motors Kinesin-based Molecular Shuttles ATP Synthase-based Nano-rotors	Problem set 7 due Problem set 8 out
18	Nanoparticle and Microparticle Biomolecule Drug Carriers Pro-drugs, Micelles, Liposomes, Polymerosomes, Nanoparticles, and Microparticles Delivery of Drugs to Tissues via Systemic Circulation Materials for Anti-Cancer Drug Delivery
19	Nanoparticle and Microparticle Biomolecule Drug Carriers (cont.) Barriers to Systemic / Oral Delivery and Delivery of Molecules to Tissues ‘Stealth’ Particles Theory of Protein-resistant Particles Experimental Function of Long-circulating Carriers and PEGylated Compounds	Problem set 8 due Take-home exam distributed
Focus Topic: Integrating Biological Knowledge Into Biomaterials Design For Vaccines
20	Basic Biology of Vaccination and Viral Infections Rudiments of Adaptive Immunity: The Basis of Vaccination Viral Infections
21	Basic Biology of Vaccination and Viral Infections (cont.) Vaccination Against Viruses: Parallels between Immunization and Infection
22	Drug Targeting and Intracellular Drug Delivery for Vaccines Targeting Nano-carriers and Micro-carriers to Specific Cell Types Chemistry of Antibodies for Targeting Pathways of Intracellular Transport
23	Drug Targeting and Intracellular Drug Delivery for Vaccines (cont.) Mechanisms of Intracellular Delivery Mimicking Viral Entry Strategies
24	DNA Vaccines Gene Therapy and DNA Immunization Mechanisms of DNA Vaccines
25	DNA Vaccines (cont.) Delivery Systems for DNA Systemic vs. Local Delivery	Take-home exam due